TY - JOUR
T1 - Chitosan-based hydrogel incorporating mesoporous silica/zinc oxide nanoparticles with controlled swelling and potent antibacterial activity
AU - Aykaç, Ahmet
AU - Ok, İzel
AU - Bakay, Emel
AU - Topaloğlu, Nermin
N1 - Publisher Copyright:
© 2024 Taylor & Francis Group, LLC.
PY - 2025
Y1 - 2025
N2 - Staphylococcus aureus (S. aureus) is a notable causative agent of bacterial infections known for its development of antibiotic resistance over time. In response, hydrogels augmented with antibacterial nanoparticles (NPs) and controllable swelling properties have emerged as promising alternatives. In the study, a novel chitosan (CS)-based hydrogel was prepared by combining CS as a main component, zinc oxide NPs (ZnO NPs) as an antibacterial agent, and mesoporous silica NPs (MSN) as the swelling control material. Comprehensive characterization of the prepared novel hydrogels were carried out by dynamic light scattering (DLS), zeta potential (ζ-potential), Brunauer–Emmett–Teller (BET) analysis, Fourier-transform infrared spectroscopy (FTIR), scanning electron microcopy (SEM), and X-ray diffraction (XRD). The ZnO/MSN/CS-based hydrogel exhibited superior swelling, precisely controllable swelling, and potent antibacterial activity against S. aureus. These hybrid CS-based hydrogels, incorporating both ZnO NPs and MSN, exhibit significant potential as agents for combating antibiotic resistance, offering an alternative strategy to mitigate reliance on conventional antibiotics.
AB - Staphylococcus aureus (S. aureus) is a notable causative agent of bacterial infections known for its development of antibiotic resistance over time. In response, hydrogels augmented with antibacterial nanoparticles (NPs) and controllable swelling properties have emerged as promising alternatives. In the study, a novel chitosan (CS)-based hydrogel was prepared by combining CS as a main component, zinc oxide NPs (ZnO NPs) as an antibacterial agent, and mesoporous silica NPs (MSN) as the swelling control material. Comprehensive characterization of the prepared novel hydrogels were carried out by dynamic light scattering (DLS), zeta potential (ζ-potential), Brunauer–Emmett–Teller (BET) analysis, Fourier-transform infrared spectroscopy (FTIR), scanning electron microcopy (SEM), and X-ray diffraction (XRD). The ZnO/MSN/CS-based hydrogel exhibited superior swelling, precisely controllable swelling, and potent antibacterial activity against S. aureus. These hybrid CS-based hydrogels, incorporating both ZnO NPs and MSN, exhibit significant potential as agents for combating antibiotic resistance, offering an alternative strategy to mitigate reliance on conventional antibiotics.
KW - Antibacterial activity
KW - chitosan
KW - hydrogel
KW - mesoporous silica nanoparticles
KW - zinc oxide nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85191193712&partnerID=8YFLogxK
U2 - 10.1080/00914037.2024.2344602
DO - 10.1080/00914037.2024.2344602
M3 - Article
AN - SCOPUS:85191193712
SN - 0091-4037
VL - 74
JO - International Journal of Polymeric Materials and Polymeric Biomaterials
JF - International Journal of Polymeric Materials and Polymeric Biomaterials
IS - 6
ER -