Cerebral glucose metabolism in dizygotic twin pairs discordant for Alzheimer's disease

JJ Virta, Mira Karrasch, J Kaprio, M Koskenvuo, I Raiha, T Viljanen, JO Rinne

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    Abstract

    Positron emission tomography (PET) with 2-deoxy-2[F-18]-fluoro-D-glucose (FDG) can be used to estimate regional cerebral glucose metabolism (rCMRgluc). FDG-PET studies have shown rCMRgluc to be reduced especially in temporal and parietal cortices in Alzheimer's disease (AD). A previous study on monozygotic twins discordant for AD showed that the rCMRgluc of the non-demented twins is reduced significantly in the lateral temporal and parietal cortices compared to unrelated controls. In this study we examined 9 pairs of dizygotic twins discordant for AD with FDG-PET. The rCMRgluc of the demented twins was 16% lower in the prefrontal cortex (p = 0.04), 20% lower in the hippocampus (p = 0.002) and 15% lower in the lateral temporal cortex (p = 0.003) compared to controls. The non-demented twins showed no such reductions on any cortical region compared to unrelated control subjects. This implies that both genes and environment, and not genes alone, are causative in the pathogenesis of AD. Copyright (c) 2007 S. Karger AG, Basel.
    Original languageUndefined/Unknown
    Pages (from-to)9–16
    Number of pages8
    JournalDementia and Geriatric Cognitive Disorders
    Volume25
    Issue number1
    DOIs
    Publication statusPublished - 2008
    MoE publication typeA1 Journal article-refereed

    Keywords

    • Alzheimer's disease
    • cerebral glucose metabolism
    • dizygotic twins

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