Cellular stress response cross talk maintains protein and energy homeostasis

Cynthia L Swan, Lea Sistonen

Research output: Contribution to journalArticleScientificpeer-review


Maintenance of cellular homeostasis depends upon several pathways that allow a cell to respond and adapt to both environmental stress and changes in metabolic status. New work in this issue of The EMBO Journal reveals a mechanism of cross talk between heat shock factor 1 (HSF1), the primary regulator of the proteotoxic stress response, and AMP-activated protein kinase (AMPK), the primary sensor in the metabolic stress response.

Original languageEnglish
Pages (from-to)267-9
Number of pages3
JournalEMBO Journal
Issue number3
Publication statusPublished - 3 Feb 2015
MoE publication typeA1 Journal article-refereed


  • AMP-Activated Protein Kinases/metabolism
  • Animals
  • DNA-Binding Proteins/metabolism
  • Heat Shock Transcription Factors
  • Neoplasm Proteins/metabolism
  • Neoplasms, Experimental/metabolism
  • Stress, Physiological
  • Transcription Factors/metabolism


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