Cell matrix adhesion in cell migration

Conway James R.W., Guillaume Jacquemet

Research output: Contribution to journalReview Article or Literature Reviewpeer-review

46 Citations (Scopus)
131 Downloads (Pure)


The ability of cells to migrate is a fundamental physiological process involved in embryonic development, tissue homeostasis, immune surveillance and wound healing. In order for cells to migrate, they must interact with their environment using adhesion receptors, such as integrins, and form specialized adhesion complexes that mediate responses to different extracellular cues. In this review, we discuss the role of integrin adhesion complexes (IACs) in cell migration, highlighting the layers of regulation that are involved, including intracellular signalling cascades, mechanosensing and reciprocal feedback to the extracellular environment. We also discuss the role of IACs in extracellular matrix remodeling and how they impact upon cell migration.
Original languageUndefined/Unknown
Pages (from-to)
JournalEssays in Biochemistry
Publication statusPublished - 2019
MoE publication typeA2 Review article in a scientific journal

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