Canonical transient receptor potential channel 2 (TRPC2): old name-new games. Importance in regulating of rat thyroid cell physiology

Kid Törnquist, P Sukumaran, Kati Kemppainen, C Löf, T Viitanen

Research output: Contribution to journalReview Article or Literature Reviewpeer-review

4 Citations (Scopus)

Abstract

  1. In addition to the TSH-cyclic AMP signalling pathway, calcium signalling is of crucial importance in thyroid cells. Although the importance of calcium signalling has been thoroughly investigated for several decades, the nature of the calcium channels involved in signalling is unknown. In a recent series of investigations using the well-studied rat thyroid FRTL-5 cell line, we showed that these cells exclusively express the transient receptor potential canonical 2 (TRPC2) channel. Our results suggested that the TRPC2 channel is of significant importance in regulating thyroid cell function. These investigations were the first to show that thyroid cells express a member of the TRPC family of ion channels. In this review, we will describe the importance of the TRPC2 channel in regulating TSH receptor expression, thyroglobulin maturation, intracellular calcium and iodide homeostasis and that the channel also regulates thyroid cell proliferation.
Original languageUndefined/Unknown
Pages (from-to)2025–2034
Number of pages10
JournalPflügers Archiv European Journal of Physiology
Volume466
Issue number11
DOIs
Publication statusPublished - 2014
MoE publication typeA2 Review article in a scientific journal

Keywords

  • Intracellular calcium
  • Rat
  • Receptor
  • Thyroid
  • TRPC2
  • TSH

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