Projects per year
Rupture or erosion of inflammatory atherosclerotic vulnerable plaque is essential to acute coronary events, while the target intervene of vulnerable plaque is very challenging, due to the relatively small volume, high hemodynamic shear stress, and multifactorial nature of the lesion foci. Herein, we utilize the biological functionality of neutrophil and the versatility of microbubble in the acoustic field, to form Neu-balloon through CD11b antibody binding. The Neu-balloon inherits the advantage of neutrophils on firming the endothelium adhesion even at shear stress up to 16 dyne/cm 2 and also maintains the acoustic enhancement property from the microbubble, to accumulate at atherosclerotic lesions under acoustic in an atherosclerotic Apo E -/- mice model. Interestingly, Neo-balloon also has high and broad drug loading capacity, which enables the delivery of indocyanine green and miR-126a-5p into vulnerable plagues in vivo. Overall, the bionic Neu-balloon holds great potential to boost on-demand drug transportation into plaques in vivo.
|Number of pages||11|
|Publication status||Published - 3 Jun 2022|
|MoE publication type||A1 Journal article-refereed|
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Åbo Akademi Functional Printing Center
Martti Toivakka (PI), Jessica Rosenholm (PI), Nicklas Anttu (PI), Johan Bobacka (PI), Tan Phat Huynh (PI), Jouko Peltonen (PI), Xiaoju Wang (PI), Carl-Eric Wilen (PI), Chunlin Xu (PI), Hongbo Zhang (PI) & Ronald Österbacka (PI)Faculty of Science and Engineering
- 2 Active
FCFH: Finland-China Network in Food and Health Sciences
Rosenholm, J., Xu, C. & Zhang, H.
Ministry of Education and Culture
01/01/21 → 31/12/24
Project: Ministry / Government Agency
Targeted delivery of CRISPR/Cas9 for advanced liver cancer therapy through c-Myc knockout
01/09/19 → 31/08/24
Project: Academy of Finland/Other Research Councils