Antithrombotic properties of sulfated wood-derived galactoglucomannans

Ales Doliska, Stefan Willför, Simona Strnad, Volker Ribitsch, Karin Stana Kleinschek, Patrik Christoffer Eklund, Xu Chunlin

    Research output: Contribution to journalArticleScientificpeer-review

    19 Citations (Scopus)

    Abstract

    Galactoglucomannans (GGMs) are water-soluble polysaccharides released and accumulated in process waters in the production of thermomechanical pulp. The general trend in the forestry industry is moving towards bio-refineries, for example utilizing these hemicelluloses as bioactive substances. At present, there is no industrial use of wood-derived mannans. In this study, GGMs extracted from thermomechanical pulp, as well as further carboxymethylated galactoglucomannans (CM-GGMs), were sulfated to increase their antithrombotic properties. The products were characterized with Fourier transform infrared spectroscopy, nuclear magnetic resonance and capillary electrophoresis. The carbohydrate composition and sulfur amounts were determined. The products' total charges were determined by polyelectrolyte titrations and their antithrombotic effect was measured based on the activated partial thromboplastin time. The results showed a significant increase in the antithrombotic effect of the sulfated galactoglucomannans from spruce wood and thus a potential new use for wood-derived mannans.
    Original languageUndefined/Unknown
    Pages (from-to)149–154
    Number of pages6
    JournalHolzforschung
    Volume66
    Issue number2
    DOIs
    Publication statusPublished - 2012
    MoE publication typeA1 Journal article-refereed

    Keywords

    • activated partial thromboplastin time
    • anticoagulant
    • antithrombocity
    • carboxymethylation
    • galactoglucomannan
    • spruce wood
    • sulfated polysaccharide

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