TY - JOUR
T1 - Antimicrobial and cytotoxic knotwood extracts and related pure compounds and their effects on food-associated microorganisms
AU - Välimaa, Anna Liisa
AU - Honkalampi-Hämäläinen, Ulla
AU - Pietarinen, Suvi
AU - Willför, Stefan
AU - Holmbom, Bjarne
AU - von Wright, Atte
N1 - Funding Information:
This research was partially supported by the Technology Development centre (TEKES). The skillful technical assistance of Riitta Venäläinen is gratefully acknowledged.
Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2007/4/30
Y1 - 2007/4/30
N2 - Knotwood or bark extracts prepared from 30 species of hard and soft wood trees as well as selected pure compounds (lignans, stilbenes and flavonoids) were assayed for their antimicrobial activity against a battery of both gram positive and negative bacteria, yeasts, and filamentous fungi (Bacillus cereus, Staphylococcus aureus, Listeria monocytogenes, Lactobacillus plantarum, Escherichia coli, Salmonella infantis, Pseudomonas fluorescens, Candida albicans, Saccharomyces cerevisiae, Aspergillus fumigatus and Penicillium brevicompactum). By far the most consistent antibacterial and antifungal properties were associated with extracts of Pinus species. These extracts showed also cytotoxicity against a mouse hepatoma cell line. Both antimicrobial and cytotoxic properties correlated with the stilbene content of the extracts. Purified stilbenes showed the most consistent antimicrobial and cytotoxic activities, while purified lignans had marginal effects, only. The results suggest that stilbenes account both for the antimicrobial and cytotoxic properties of Pinus knotwood extracts.
AB - Knotwood or bark extracts prepared from 30 species of hard and soft wood trees as well as selected pure compounds (lignans, stilbenes and flavonoids) were assayed for their antimicrobial activity against a battery of both gram positive and negative bacteria, yeasts, and filamentous fungi (Bacillus cereus, Staphylococcus aureus, Listeria monocytogenes, Lactobacillus plantarum, Escherichia coli, Salmonella infantis, Pseudomonas fluorescens, Candida albicans, Saccharomyces cerevisiae, Aspergillus fumigatus and Penicillium brevicompactum). By far the most consistent antibacterial and antifungal properties were associated with extracts of Pinus species. These extracts showed also cytotoxicity against a mouse hepatoma cell line. Both antimicrobial and cytotoxic properties correlated with the stilbene content of the extracts. Purified stilbenes showed the most consistent antimicrobial and cytotoxic activities, while purified lignans had marginal effects, only. The results suggest that stilbenes account both for the antimicrobial and cytotoxic properties of Pinus knotwood extracts.
KW - Antibacterial activity
KW - Antifungal activity
KW - Cytotoxicity
KW - Food microorganisms
KW - Knotwood
KW - Pinosylvin
KW - Pinus
KW - Stilbenes
UR - http://www.scopus.com/inward/record.url?scp=33847777654&partnerID=8YFLogxK
U2 - 10.1016/j.ijfoodmicro.2006.10.031
DO - 10.1016/j.ijfoodmicro.2006.10.031
M3 - Article
C2 - 17188387
AN - SCOPUS:33847777654
SN - 0168-1605
VL - 115
SP - 235
EP - 243
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
IS - 2
ER -