Anti-bacterial activity of inorganic nanomaterials and their antimicrobial peptide conjugates against resistant and non-resistant pathogens

Dinesh M. Pardhi, Didem Sen Karaman, Juri Timonen, Wei Wu, Qi Zhang, Saurabh Satija, Meenu Mehta, Nitin Charbe, Paul A. McCarron, Murtaza M. Tambuwala, Hamid A. Bakshi, Poonam Negi, Alaa A. Aljabali, Kamal Dua, Dinesh K. Chellappan, Ajit Behera, Kamla Pathak, Ritesh B. Watharkar, Jarkko Rautio, Jessica M. Rosenholm

Research output: Contribution to journalArticleScientificpeer-review

42 Citations (Scopus)
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This review details the antimicrobial applications of inorganic nanomaterials of mostly metallic form, and the augmentation of activity by surface conjugation of peptide ligands. The review is subdivided into three main sections, of which the first describes the antimicrobial activity of inorganic nanomaterials against gram-positive, gram-negative and multidrug-resistant bacterial strains. The second section highlights the range of antimicrobial peptides and the drug resistance strategies employed by bacterial species to counter lethality. The final part discusses the role of antimicrobial peptide-decorated inorganic nanomaterials in the fight against bacterial strains that show resistance. General strategies for the preparation of antimicrobial peptides and their conjugation to nanomaterials are discussed, emphasizing the use of elemental and metallic oxide nanomaterials. Importantly, the permeation of antimicrobial peptides through the bacterial membrane is shown to aid the delivery of nanomaterials into bacterial cells. By judicious use of targeting ligands, the nanomaterial becomes able to differentiate between bacterial and mammalian cells and, thus, reduce side effects. Moreover, peptide conjugation to the surface of a nanomaterial will alter surface chemistry in ways that lead to reduction in toxicity and improvements in biocompatibility.
Original languageEnglish
Article number119531
Number of pages21
JournalInternational Journal of Pharmaceutics
Publication statusPublished - 30 Aug 2020
MoE publication typeA1 Journal article-refereed


  • Nanomaterial
  • Antimicrobial
  • Conjugates
  • Antimicrobial peptides
  • Antibiotics


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