Anionic cellulose beads for drug encapsulation and release

Jani Trygg, Emrah Yildir, Ruzica Kolakovic, Niklas Sandler, Pedro Fardim

Research output: Contribution to journalArticleScientificpeer-review

21 Citations (Scopus)

Abstract

Cellulose beads were prepared from water-based solvent and oxidised by modified Anelli's reaction at 20- for 2-48 h (Fig. 1). The maximum amount of anionic groups (AGs) was . The distribution of AGs was verified by absorption of cationic dyes and imaging with confocal fluorescent microscopy. Structural changes were studied spectroscopically and with electron microscopy. Oxidation of the beads drastically increased the swelling capacity of air-dried beads. Uptake of model drug was more than doubled in never-dried beads. This is due to the changes in pore size distribution, mainly opening and widening of the closed pores and narrow cavities. Release profiles of the drug were studied at physiological pH of 7.4 and showed a controlled release rate independently of the amount of the drug encapsulated and amount of AGs.
Original languageUndefined/Unknown
Pages (from-to)1945–1955
JournalCellulose
Volume21
Issue number3
DOIs
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed

Keywords

  • TEMPO oxidation
  • Cellulose beads
  • Microspheres
  • drug delivery

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