An impedance QCM study on the partitioning of bioactive compounds in supported phospholipid bilayers

Klaara Kannisto, Lasse Murtomäki*, Tapani Viitala

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

20 Citations (Scopus)

Abstract

The interaction of two drugs of small molecular size, propranolol and tetracaine, and the membrane-perturbing peptide melittin with a phospholipid bilayer supported on a SiO2 surface was studied with the quartz crystal microbalance. All three bioactive compounds interacted with the lipid bilayer and changed its viscoelastic properties. Adsorbed mass of the compounds was analyzed with a viscoelastic model as a function of the concentration of the compounds in the aqueous phase, as well as the effect of the compounds on the bilayer viscoelasticity. The analysis was based on the interpretation of the impedance of the crystal, utilizing the 5th, 7th and 9th overtone of the fundamental 5MHz resonance frequency.

Original languageEnglish
Pages (from-to)298-304
Number of pages7
JournalColloids and Surfaces B: Biointerfaces
Volume86
Issue number2
DOIs
Publication statusPublished - 1 Sep 2011
Externally publishedYes
MoE publication typeA1 Journal article-refereed

Keywords

  • Adsorption
  • Phospholipid bilayer
  • Quartz crystal microbalance
  • Viscoelasticity

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