An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity

Helinä Kahma; Laura Aurinsalo; Mikko Neuvonen; Jani Katajamäki; Marie-Noëlle Paludetto; Jenni Viinamäki; Terhi Launiainen; Anne M. Filppula; Aleksi Tornio; Mikko Niemi; Janne T. Backman

doi:10.1016/j.ejps.2021.105810

An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity

Helinä Kahma, Laura Aurinsalo, Mikko Neuvonen, Jani Katajamäki, Marie-Noëlle Paludetto, Jenni Viinamäki, Terhi Launiainen, Anne M. Filppula, Aleksi Tornio, Mikko Niemi, Janne T. Backman

Research output: Contribution to journal › Article › Scientific › peer-review

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Original language	English
Article number	105810
Journal	European Journal of Pharmaceutical Sciences
Volume	162
DOIs	https://doi.org/10.1016/j.ejps.2021.105810
Publication status	Published - Jul 2021
Externally published	Yes
MoE publication type	A1 Journal article-refereed

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10.1016/j.ejps.2021.105810

1-s2.0-S0928098721001123-mainFinal published version, 2.86 MBLicence: CC BY-NC-ND

https://urn.fi/URN:NBN:fi-fe2022030421819

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Kahma, H., Aurinsalo, L., Neuvonen, M., Katajamäki, J., Paludetto, M.-N., Viinamäki, J., Launiainen, T., Filppula, A. M., Tornio, A., Niemi, M., & Backman, J. T. (2021). An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity. European Journal of Pharmaceutical Sciences, 162, Article 105810. https://doi.org/10.1016/j.ejps.2021.105810

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title = "An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity",

author = "Helin{\"a} Kahma and Laura Aurinsalo and Mikko Neuvonen and Jani Katajam{\"a}ki and Marie-No{\"e}lle Paludetto and Jenni Viinam{\"a}ki and Terhi Launiainen and Filppula, {Anne M.} and Aleksi Tornio and Mikko Niemi and Backman, {Janne T.}",

year = "2021",

month = jul,

doi = "10.1016/j.ejps.2021.105810",

language = "English",

volume = "162",

journal = "European Journal of Pharmaceutical Sciences",

issn = "0928-0987",

publisher = "Elsevier",

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Kahma, H, Aurinsalo, L, Neuvonen, M, Katajamäki, J, Paludetto, M-N, Viinamäki, J, Launiainen, T, Filppula, AM, Tornio, A, Niemi, M & Backman, JT 2021, 'An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity', European Journal of Pharmaceutical Sciences, vol. 162, 105810. https://doi.org/10.1016/j.ejps.2021.105810

An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity. / Kahma, Helinä; Aurinsalo, Laura; Neuvonen, Mikko et al.
In: European Journal of Pharmaceutical Sciences, Vol. 162, 105810, 07.2021.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity

AU - Kahma, Helinä

AU - Aurinsalo, Laura

AU - Neuvonen, Mikko

AU - Katajamäki, Jani

AU - Paludetto, Marie-Noëlle

AU - Viinamäki, Jenni

AU - Launiainen, Terhi

AU - Filppula, Anne M.

AU - Tornio, Aleksi

AU - Niemi, Mikko

AU - Backman, Janne T.

PY - 2021/7

Y1 - 2021/7

UR - https://doi.org/10.1016/j.ejps.2021.105810

U2 - 10.1016/j.ejps.2021.105810

DO - 10.1016/j.ejps.2021.105810

M3 - Article

SN - 0928-0987

VL - 162

JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

M1 - 105810

ER -

Kahma H, Aurinsalo L, Neuvonen M, Katajamäki J, Paludetto MN, Viinamäki J et al. An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity. European Journal of Pharmaceutical Sciences. 2021 Jul;162:105810. doi: 10.1016/j.ejps.2021.105810

An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity

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