Alternative splicing of human and mouse NPFF2 receptor genes: Implications to receptor expression

Minna-Liisa Ankö; Maria Ostergård; Minnamaija Lintunen; Pertti Panula

doi:10.1016/j.febslet.2006.11.063

Alternative splicing of human and mouse NPFF2 receptor genes: Implications to receptor expression

Minna-Liisa Ankö
, Maria Ostergård
, Minnamaija Lintunen
, Pertti Panula

Biochemistry and Cell Biology

Research output: Contribution to journal › Article › Scientific › peer-review

8 Citations (Scopus)

Abstract

Alternative splicing has an important role in the tissue-specific regulation of gene expression. Here we report that similar to the human NPFF2 receptor, the mouse NPFF2 receptor is alternatively spliced. In human the presence of three alternatively spliced receptor variants were verified, whereas two NPFF2 receptor variants were identified in mouse. The alternative splicing affected the 5' untranslated region of the mouse receptor and the variants in mouse were differently distributed. The mouse NPFF system may also have species-specific features since the NPFF2 receptor mRNA expression differs from that reported for rat.

Original language	English
Pages (from-to)	6955-60
Number of pages	6
Journal	FEBS Letters
Volume	580
Issue number	30
DOIs	https://doi.org/10.1016/j.febslet.2006.11.063
Publication status	Published - 22 Dec 2006
MoE publication type	A1 Journal article-refereed

Keywords

Alternative Splicing/genetics
Animals
Base Sequence
Central Nervous System/metabolism
Humans
In Situ Hybridization
Mice
Molecular Sequence Data
Protein Isoforms/genetics
RNA, Messenger/genetics
Receptors, Neuropeptide/genetics

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10.1016/j.febslet.2006.11.063

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title = "Alternative splicing of human and mouse NPFF2 receptor genes: Implications to receptor expression",

abstract = "Alternative splicing has an important role in the tissue-specific regulation of gene expression. Here we report that similar to the human NPFF2 receptor, the mouse NPFF2 receptor is alternatively spliced. In human the presence of three alternatively spliced receptor variants were verified, whereas two NPFF2 receptor variants were identified in mouse. The alternative splicing affected the 5' untranslated region of the mouse receptor and the variants in mouse were differently distributed. The mouse NPFF system may also have species-specific features since the NPFF2 receptor mRNA expression differs from that reported for rat.",

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T1 - Alternative splicing of human and mouse NPFF2 receptor genes

T2 - Implications to receptor expression

AU - Ankö, Minna-Liisa

AU - Ostergård, Maria

AU - Lintunen, Minnamaija

AU - Panula, Pertti

PY - 2006/12/22

Y1 - 2006/12/22

N2 - Alternative splicing has an important role in the tissue-specific regulation of gene expression. Here we report that similar to the human NPFF2 receptor, the mouse NPFF2 receptor is alternatively spliced. In human the presence of three alternatively spliced receptor variants were verified, whereas two NPFF2 receptor variants were identified in mouse. The alternative splicing affected the 5' untranslated region of the mouse receptor and the variants in mouse were differently distributed. The mouse NPFF system may also have species-specific features since the NPFF2 receptor mRNA expression differs from that reported for rat.

AB - Alternative splicing has an important role in the tissue-specific regulation of gene expression. Here we report that similar to the human NPFF2 receptor, the mouse NPFF2 receptor is alternatively spliced. In human the presence of three alternatively spliced receptor variants were verified, whereas two NPFF2 receptor variants were identified in mouse. The alternative splicing affected the 5' untranslated region of the mouse receptor and the variants in mouse were differently distributed. The mouse NPFF system may also have species-specific features since the NPFF2 receptor mRNA expression differs from that reported for rat.

KW - Alternative Splicing/genetics

KW - Animals

KW - Base Sequence

KW - Central Nervous System/metabolism

KW - Humans

KW - In Situ Hybridization

KW - Mice

KW - Molecular Sequence Data

KW - Protein Isoforms/genetics

KW - RNA, Messenger/genetics

KW - Receptors, Neuropeptide/genetics

UR - http://europepmc.org/abstract/med/17157836

U2 - 10.1016/j.febslet.2006.11.063

DO - 10.1016/j.febslet.2006.11.063

M3 - Article

C2 - 17157836

SN - 0014-5793

VL - 580

SP - 6955

EP - 6960

JO - FEBS Letters

JF - FEBS Letters

IS - 30

ER -

Alternative splicing of human and mouse NPFF2 receptor genes: Implications to receptor expression

Abstract

Keywords

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