Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors

Moriah R. Arnold, Marie France Langelier, Jessica Gartrell, Ilsa T. Kirby, Daniel J. Sanderson, Daniel S. Bejan, Justina Šileikytė, Sunil K. Sundalam, Shanthi Nagarajan, Parthiban Marimuthu, Anna K. Duell, Anang A. Shelat, John M. Pascal, Michael S. Cohen*

*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

3 Citations (Scopus)

Fingerprint

Dive into the research topics of 'Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors'. Together they form a unique fingerprint.

Medicine and Dentistry

Pharmacology, Toxicology and Pharmaceutical Science