Aldolization of butyraldehyde with formaldehyde over a commercial anion-exchange resin - Kinetics and selectivity aspects

V. Serra-Holm, T. Salmi*, J. Multamäki, J. Reinik, P. Mäki-Arvela, R. Sjöholm, L. P. Lindfors

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

32 Citations (Scopus)

Abstract

Butyraldehyde was aldolized with formaldehyde at 40-80°C over an anion-exchange resin catalyst in aqueous and methanolic solutions. The reaction mixture was analyzed with gas and liquid chromatography as well as nuclear magnetic resonance (NMR) spectroscopy. Two main products were detected: 2-ethyl-3-hydroxy-2-hydroxymethylpropanal (trimethylolpropane aldol) and 2-ethylpropenal (ethylacrolein). The molar ratio of the main products was dependent on the formaldehyde-tobutyraldehyde ratio and the solvent composition but independent of the temperature. The yield of 2-ethyl-3-hydroxy-2- hydroximethylpropanal increased with increasing formaldehyde-to-butyraldehyde ratio and with increasing water-to-methanol content of the reaction mixture. Besides the main reactions, self-condensation and acetalization of butyraldehyde were detected as side reactions of minor importance. The self-condensation of butyraldehyde was suppressed in the presence of formaldehyde and the acetalization of butyraldehyde was minimized by the use of water as reaction solvent. Rate equations were derived starting from molecular reaction mechanisms and adsorption of formaldehyde on the catalyst structure. It turned out that the rate equations can predict the distribution of the main products.

Original languageEnglish
Pages (from-to)207-221
Number of pages15
JournalApplied Catalysis A: General
Volume198
Issue number1-2
DOIs
Publication statusPublished - 15 May 2000
MoE publication typeA1 Journal article-refereed

Keywords

  • Aldolization
  • Anion-exchange resin catalyst
  • Butyraldehyde
  • Elimination
  • Formaldehyde

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