Acylation of (R,S)-1-phenylethanol with ethyl acetate over an immobilized enzyme

Päivi Mäki-Arvela*, Serap Sahin, Kari Eränen, Dmitry Yu Murzin

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)

Abstract

Acylation of (R,S)-1-phenylethanol, which is a product of acetophenone hydrogenation, over a Pd-supported catalyst, was studied in ethyl acetate with an immobilized lipase. It was demonstrated that in the presence of hydrogen and Pd/C in the reaction medium the (R,S)-1-phenylethanol acylation rate is not hindered, whereas the selectivity was strongly altered in the latter case, leading to significant amounts of side products.

Original languageEnglish
Pages (from-to)245-252
Number of pages8
JournalResearch on Chemical Intermediates
Volume36
Issue number3
DOIs
Publication statusPublished - Apr 2010
MoE publication typeA1 Journal article-refereed

Keywords

  • Acylation
  • Hydrogen
  • Lipase
  • Pd/C catalyst

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