Acylation of (R,S)-1-phenylethanol with ethyl acetate over an immobilized enzyme

Päivi Mäki-Arvela; Serap Sahin; Kari Eränen; Dmitry Yu Murzin

doi:10.1007/s11164-010-0127-4

Acylation of (R,S)-1-phenylethanol with ethyl acetate over an immobilized enzyme

Päivi Mäki-Arvela^*, Serap Sahin, Kari Eränen, Dmitry Yu Murzin

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

2 Citations (Scopus)

Abstract

Acylation of (R,S)-1-phenylethanol, which is a product of acetophenone hydrogenation, over a Pd-supported catalyst, was studied in ethyl acetate with an immobilized lipase. It was demonstrated that in the presence of hydrogen and Pd/C in the reaction medium the (R,S)-1-phenylethanol acylation rate is not hindered, whereas the selectivity was strongly altered in the latter case, leading to significant amounts of side products.

Original language	English
Pages (from-to)	245-252
Number of pages	8
Journal	Research on Chemical Intermediates
Volume	36
Issue number	3
DOIs	https://doi.org/10.1007/s11164-010-0127-4
Publication status	Published - Apr 2010
MoE publication type	A1 Journal article-refereed

Keywords

Acylation
Hydrogen
Lipase
Pd/C catalyst

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10.1007/s11164-010-0127-4

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abstract = "Acylation of (R,S)-1-phenylethanol, which is a product of acetophenone hydrogenation, over a Pd-supported catalyst, was studied in ethyl acetate with an immobilized lipase. It was demonstrated that in the presence of hydrogen and Pd/C in the reaction medium the (R,S)-1-phenylethanol acylation rate is not hindered, whereas the selectivity was strongly altered in the latter case, leading to significant amounts of side products.",

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AU - Mäki-Arvela, Päivi

AU - Sahin, Serap

AU - Eränen, Kari

AU - Murzin, Dmitry Yu

PY - 2010/4

Y1 - 2010/4

N2 - Acylation of (R,S)-1-phenylethanol, which is a product of acetophenone hydrogenation, over a Pd-supported catalyst, was studied in ethyl acetate with an immobilized lipase. It was demonstrated that in the presence of hydrogen and Pd/C in the reaction medium the (R,S)-1-phenylethanol acylation rate is not hindered, whereas the selectivity was strongly altered in the latter case, leading to significant amounts of side products.

AB - Acylation of (R,S)-1-phenylethanol, which is a product of acetophenone hydrogenation, over a Pd-supported catalyst, was studied in ethyl acetate with an immobilized lipase. It was demonstrated that in the presence of hydrogen and Pd/C in the reaction medium the (R,S)-1-phenylethanol acylation rate is not hindered, whereas the selectivity was strongly altered in the latter case, leading to significant amounts of side products.

KW - Acylation

KW - Hydrogen

KW - Lipase

KW - Pd/C catalyst

UR - http://www.scopus.com/inward/record.url?scp=77952551248&partnerID=8YFLogxK

U2 - 10.1007/s11164-010-0127-4

DO - 10.1007/s11164-010-0127-4

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JO - Research on Chemical Intermediates

JF - Research on Chemical Intermediates

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ER -

Acylation of (R,S)-1-phenylethanol with ethyl acetate over an immobilized enzyme

Abstract

Keywords

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