Activation of c-ras oncogenes by mutations and amplification

L Sistonen, K Alitalo

Research output: Contribution to journalReview Article or Literature Reviewpeer-review


About 15% of all human tumours, including carcinomas, sarcomas, melanomas and leukaemias, contain c-ras oncogenes, which can be detected by a variety of methods. The activating lesion in the c-ras oncogenes is most often a point mutation affecting certain critical amino acid residues of its protein product. The clinical significance of c-ras oncogenes is not yet clear.

Original languageEnglish
Pages (from-to)297-303
Number of pages7
JournalAnnals of Clinical Research
Issue number5-6
Publication statusPublished - 1986
MoE publication typeA2 Review article in a scientific journal


  • Animals
  • Cell Transformation, Neoplastic
  • Gene Amplification
  • Gene Expression Regulation
  • Humans
  • Mutation
  • Oncogenes
  • Proto-Oncogenes


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