TY - JOUR
T1 - Accelerating Wound Healing with Combinatorial Therapy Using Natural Melanin Nanoparticle-Polyvinyl Alcohol Blend and Core-Sheath Hybrid Nanofibers under UV-A Irradiation
AU - Bayrak, Emirhan
AU - Yiğit, Pelin
AU - Bakay, Emel
AU - Sirek, Busra
AU - Topaloğlu, Nermin
AU - Baysoy, Engin
AU - Kaleli-Can, Gizem
N1 - Publisher Copyright:
© 2024 The Authors. Macromolecular Materials and Engineering published by Wiley-VCH GmbH.
PY - 2024/5
Y1 - 2024/5
N2 - Wound healing can be a complex and slow process for the human body, particularly if it is chronic. Photothermal therapy (PTT) and photodynamic therapy (PDT) can be used to accelerate wound healing. As opposed to current PDT studies using well-known photosensitizers, this work use novel polyvinyl alcohol (PVA) and melanin nanoparticles (MNPs) containing hybrid nanofibers prepared by electrospinning techniques to enhance wound healing with/without UV light. Blend and core-sheath nozzles are utilized to obtain sustainable and biocompatible MNP-PVA blend, and core-sheath hybrid nanofibers and 30, 60, and 300 s of UV-A irradiation are tested in terms of photoinactivation efficiencies for Escherichia coli (E. coli). The MNP-PVA blend with a diameter of 324 nm and the core-sheath nanofibers with a diameter of 468 nm both showed killing effect on E. coli about 41.6% and 32%, respectively, under 30 s of UV-A irradiation. Increased irradiation time activates the protective effect of MNPs located in nanofibers, thereby decreasing photoinactivation efficiency. Moreover, the MNP-PVA core-sheath nanofibers with 30 s of UV-A irradiation promote the closure of wound to 99.2% at 24 h.
AB - Wound healing can be a complex and slow process for the human body, particularly if it is chronic. Photothermal therapy (PTT) and photodynamic therapy (PDT) can be used to accelerate wound healing. As opposed to current PDT studies using well-known photosensitizers, this work use novel polyvinyl alcohol (PVA) and melanin nanoparticles (MNPs) containing hybrid nanofibers prepared by electrospinning techniques to enhance wound healing with/without UV light. Blend and core-sheath nozzles are utilized to obtain sustainable and biocompatible MNP-PVA blend, and core-sheath hybrid nanofibers and 30, 60, and 300 s of UV-A irradiation are tested in terms of photoinactivation efficiencies for Escherichia coli (E. coli). The MNP-PVA blend with a diameter of 324 nm and the core-sheath nanofibers with a diameter of 468 nm both showed killing effect on E. coli about 41.6% and 32%, respectively, under 30 s of UV-A irradiation. Increased irradiation time activates the protective effect of MNPs located in nanofibers, thereby decreasing photoinactivation efficiency. Moreover, the MNP-PVA core-sheath nanofibers with 30 s of UV-A irradiation promote the closure of wound to 99.2% at 24 h.
KW - electrospinning
KW - melanin nanoparticles
KW - nanoparticle-nanofiber composites
KW - photodynamic therapy
KW - wound healing
UR - http://www.scopus.com/inward/record.url?scp=85185102800&partnerID=8YFLogxK
U2 - 10.1002/mame.202300382
DO - 10.1002/mame.202300382
M3 - Article
AN - SCOPUS:85185102800
SN - 1438-7492
VL - 309
JO - Macromolecular Materials and Engineering
JF - Macromolecular Materials and Engineering
IS - 5
M1 - 2300382
ER -