A simple mass-action model for the eukaryotic heat shock response and its mathematical validation

Ion Petre, A Mizera, Claire Hyder, Annika Meinander, A Mikhailov, RI Morimoto, Lea Sistonen, John Eriksson, RJ Back

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    41 Citations (Scopus)

    Abstract

    The heat shock response is a primordial defense mechanism against cell stress and protein misfolding. It proceeds with the minimum number of mechanisms that any regulatory network must include, a stress-induced activation and a feedback regulation, and can thus be regarded as the archetype for a cellular regulatory process. We propose here a simple mechanistic model for the eukaryotic heat shock response, including its mathematical validation. Based on numerical predictions of the model and on its sensitivity analysis, we minimize the model by identifying the reactions with marginal contribution to the heat shock response. As the heat shock response is a very basic and conserved regulatory network, our analysis of the network provides a useful foundation for modeling strategies of more complex cellular processes.
    Original languageUndefined/Unknown
    Pages (from-to)595–612
    Number of pages18
    JournalNatural Computing
    Volume10
    Issue number1
    DOIs
    Publication statusPublished - 2011
    MoE publication typeA1 Journal article-refereed

    Keywords

    • Heat shock element
    • Heat shock factor
    • Heat shock protein
    • Heat shock response
    • Mathematical model
    • Regulatory network

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