@article{fb602d1f222443d190e8288a6a2c262e,
title = "A novel cancer vaccine for melanoma based on an approved vaccine against measles, mumps, and rubella",
abstract = "Common vaccines for infectious diseases have been repurposed as cancer immunotherapies. The intratumoral administration of these repurposed vaccines can induce immune cell infiltration into the treated tumor. Here, we have used an approved trivalent live attenuated measles, mumps, and rubella (MMR) vaccine in our previously developed PeptiENV cancer vaccine platform. The intratumoral administration of this novel MMR-containing PeptiENV cancer vaccine significantly increased both intratumoral as well as systemic tumor-specific T cell responses. In addition, PeptiENV therapy, in combination with immune checkpoint inhibitor therapy, improved tumor growth control and survival as well as increased the number of mice responsive to immune checkpoint inhibitor therapy. Importantly, mice pre-vaccinated with the MMR vaccine responded equally well, if not better, to the PeptiENV therapy, indicating that pre-existing immunity against the MMR vaccine viruses does not compromise the use of this novel cancer vaccine platform.",
keywords = "cancer vaccines, measles, mumps, oncolytic viruses, PeptiENV, personalized medicine, Priorix, rubella",
author = "Manlio Fusciello and Erkko Yl{\"o}sm{\"a}ki and Sara Feola and Arttu Uoti and Beatriz Martins and Karri Aalto and Firas Hamdan and Jacopo Chiaro and Salvatore Russo and Tapani Viitala and Vincenzo Cerullo",
note = "Funding Information: E.Y. received funding from the Academy of Finland (project No. 1317206 ). V.C. received funding from the European Research Council under the Horizon 2020 framework ( https://erc.europa.eu ), ERC -consolidator Grant (Agreement No. 681219 ), Jane and Aatos Erkko Foundation (Project No. 4705796 ), HiLIFE Fellow (project No. 797011004 ), Cancer Finnish Foundation (project No. 4706116 ), Magnus Ehrnrooth Foundation (project No. 4706235 ), and the Academy of Finland and Digital Precision Cancer Medicine Flagship iCAN. Funding Information: E.Y. received funding from the Academy of Finland (project No. 1317206). V.C. received funding from the European Research Council under the Horizon 2020 framework (https://erc.europa.eu), ERC-consolidator Grant (Agreement No. 681219), Jane and Aatos Erkko Foundation (Project No. 4705796), HiLIFE Fellow (project No. 797011004), Cancer Finnish Foundation (project No. 4706116), Magnus Ehrnrooth Foundation (project No. 4706235), and the Academy of Finland and Digital Precision Cancer Medicine Flagship iCAN. E.Y. M.F. A.U. and V.C. conceived and planned the experiments. E.Y. M.F. A.U. S.F. F.H. J.C. K.A. and T.V. carried out the experiments. E.Y. M.F. A.U. B.M. S.F. F.H. J.C. K.A. T.V. and V.C. contributed to the interpretation of the results. E.Y. wrote the manuscript. All authors provided critical feedback and helped shape the research, analysis, and manuscript. Vincenzo Cerullo is a co-founder and shareholder at VALO therapeutics. Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2022",
month = jun,
day = "16",
doi = "10.1016/j.omto.2022.04.002",
language = "English",
volume = "25",
pages = "137--145",
journal = "Molecular Therapy - Oncolytics",
issn = "2372-7705",
publisher = "Cell Press",
}