A New Mathematical Model for the Heat Shock Response

Ion Petre; A Mizera; Claire Hyder; A Mikhailov; John Eriksson; Lea Sistonen; Ralph-Johan Back

doi:10.1007/978-3-540-88869-7_21

A New Mathematical Model for the Heat Shock Response

Ion Petre, A Mizera, Claire Hyder, A Mikhailov, John Eriksson, Lea Sistonen, Ralph-Johan Back

Research output: Chapter in Book/Conference proceeding › Chapter › Scientific › peer-review

9 Citations (Scopus)

Abstract

We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins, and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.

Original language	Undefined/Unknown
Title of host publication	Algorithmic bioprocesses
Editors	Anne Condon, David Harel, Joost N. Kok, Arto Salomaa, Erik Winfree
Publisher	Springer
Pages	411–425
Number of pages	15
ISBN (Print)	9783540888697
DOIs	https://doi.org/10.1007/978-3-540-88869-7_21
Publication status	Published - 2009
MoE publication type	A3 Part of a book or another research book

Access to Document

10.1007/978-3-540-88869-7_21

Cite this

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title = "A New Mathematical Model for the Heat Shock Response",

abstract = "We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins, and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.",

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T1 - A New Mathematical Model for the Heat Shock Response

AU - Petre, Ion

AU - Mizera, A

AU - Hyder, Claire

AU - Mikhailov, A

AU - Eriksson, John

AU - Sistonen, Lea

AU - Back, Ralph-Johan

PY - 2009

Y1 - 2009

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AB - We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins, and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.

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DO - 10.1007/978-3-540-88869-7_21

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BT - Algorithmic bioprocesses

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A2 - Harel, David

A2 - Kok, Joost N.

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A2 - Winfree, Erik

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