Abstract
We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins, and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.
Original language | Undefined/Unknown |
---|---|
Title of host publication | Algorithmic bioprocesses |
Editors | Anne Condon, David Harel, Joost N. Kok, Arto Salomaa, Erik Winfree |
Publisher | Springer |
Pages | 411–425 |
Number of pages | 15 |
ISBN (Print) | 9783540888697 |
DOIs | |
Publication status | Published - 2009 |
MoE publication type | A3 Part of a book or another research book |