We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins, and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.
|Title of host publication||Algorithmic bioprocesses|
|Editors||Anne Condon, David Harel, Joost N. Kok, Arto Salomaa, Erik Winfree|
|Number of pages||15|
|Publication status||Published - 2009|
|MoE publication type||A3 Part of a book or another research book|