A New Mathematical Model for the Heat Shock Response

Ion Petre, A Mizera, Claire Hyder, A Mikhailov, John Eriksson, Lea Sistonen, Ralph-Johan Back

    Research output: Chapter in Book/Conference proceedingChapterScientificpeer-review

    9 Citations (Scopus)


    We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins, and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.
    Original languageUndefined/Unknown
    Title of host publicationAlgorithmic bioprocesses
    EditorsAnne Condon, David Harel, Joost N. Kok, Arto Salomaa, Erik Winfree
    Number of pages15
    ISBN (Print)9783540888697
    Publication statusPublished - 2009
    MoE publication typeA3 Part of a book or another research book

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