A label-free immunosensor based on a graphene water-gated field-effect transistor

Rosaria Anna Picca; Davide Blasi; Eleonora MacChia; Kyriaki Manoli; Cinzia Di Franco; Gaetano Scamarcio; Fabrizio Torricelli; Amaia Zurutuza; Ilargi Napal; Alba Centeno; Luisa Torsi

doi:10.1109/IWASI.2019.8791429

A label-free immunosensor based on a graphene water-gated field-effect transistor

Rosaria Anna Picca, Davide Blasi, Eleonora MacChia, Kyriaki Manoli, Cinzia Di Franco, Gaetano Scamarcio, Fabrizio Torricelli, Amaia Zurutuza, Ilargi Napal, Alba Centeno, Luisa Torsi

Research output: Chapter in Book/Conference proceeding › Published conference proceeding › Scientific › peer-review

7 Citations (Scopus)

Abstract

Electrolyte-gated graphene field-effect transistors are here proposed for biosensing applications. To this end, a label-free immunosensor based on this technology is employed for the sensitive and selective detection of IgG. Differently from the typical approach based on the bioreceptor immobilization onto a graphene layer, in this work sensitivity in the lower femtomolar range can be reached thanks to the formation of a closely packed layer of anti-IgG receptors anchored to the gold gate electrode.

Original language	English
Title of host publication	Proceedings - 2019 8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019
Publisher	the Institute of Electrical and Electronics Engineers, Inc.
Pages	136-138
Number of pages	3
ISBN (Electronic)	9781728105567
DOIs	https://doi.org/10.1109/IWASI.2019.8791429
Publication status	Published - Jun 2019
MoE publication type	A4 Article in a conference publication
Event	8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019 - Otranto, Italy Duration: 13 Jun 2019 → 14 Jun 2019

Publication series

Name	Proceedings - 2019 8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019

Conference

Conference	8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019
Country/Territory	Italy
City	Otranto
Period	13/06/19 → 14/06/19

Funding

ACKNOWLEDGMENTS The following grants are acknowledged for partial financial support: Regione Puglia - Future in Research − BEND: Biosensori elettronici intelligenti per la diagnosi precoce di malattie neurodegenerative (B164PG8); "SiMoT: Single molecule bio-electronic smart system array for clinical testing" funded by the European Commission under H2020 program, grant #824946; MIUR PON - e-DESIGN: Combination of Design, Electronics and Multifunctional Materials for New Aesthetic Components (ARS01_01158). CSGI is also acknowledged for partial financial support.

Keywords

biosensor
electrolyte-gated thin film transistor
gate functionalization
graphene
label-free

Access to Document

10.1109/IWASI.2019.8791429

Cite this

Picca, R. A., Blasi, D., MacChia, E., Manoli, K., Di Franco, C., Scamarcio, G., Torricelli, F., Zurutuza, A., Napal, I., Centeno, A., & Torsi, L. (2019). A label-free immunosensor based on a graphene water-gated field-effect transistor. In Proceedings - 2019 8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019 (pp. 136-138). Article 8791429 (Proceedings - 2019 8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019). the Institute of Electrical and Electronics Engineers, Inc.. https://doi.org/10.1109/IWASI.2019.8791429

Picca, Rosaria Anna ; Blasi, Davide ; MacChia, Eleonora et al. / A label-free immunosensor based on a graphene water-gated field-effect transistor. Proceedings - 2019 8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019. the Institute of Electrical and Electronics Engineers, Inc., 2019. pp. 136-138 (Proceedings - 2019 8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019).

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title = "A label-free immunosensor based on a graphene water-gated field-effect transistor",

abstract = "Electrolyte-gated graphene field-effect transistors are here proposed for biosensing applications. To this end, a label-free immunosensor based on this technology is employed for the sensitive and selective detection of IgG. Differently from the typical approach based on the bioreceptor immobilization onto a graphene layer, in this work sensitivity in the lower femtomolar range can be reached thanks to the formation of a closely packed layer of anti-IgG receptors anchored to the gold gate electrode.",

keywords = "biosensor, electrolyte-gated thin film transistor, gate functionalization, graphene, label-free",

author = "Picca, \{Rosaria Anna\} and Davide Blasi and Eleonora MacChia and Kyriaki Manoli and \{Di Franco\}, Cinzia and Gaetano Scamarcio and Fabrizio Torricelli and Amaia Zurutuza and Ilargi Napal and Alba Centeno and Luisa Torsi",

note = "Funding Information: ACKNOWLEDGMENTS The following grants are acknowledged for partial financial support: Regione Puglia - Future in Research − BEND: Biosensori elettronici intelligenti per la diagnosi precoce di malattie neurodegenerative (B164PG8); {"}SiMoT: Single molecule bio-electronic smart system array for clinical testing{"} funded by the European Commission under H2020 program, grant \#824946; MIUR PON - e-DESIGN: Combination of Design, Electronics and Multifunctional Materials for New Aesthetic Components (ARS01\_01158). CSGI is also acknowledged for partial financial support. Publisher Copyright: {\textcopyright} 2019 IEEE. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.; 8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019 ; Conference date: 13-06-2019 Through 14-06-2019",

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doi = "10.1109/IWASI.2019.8791429",

language = "English",

series = "Proceedings - 2019 8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019",

publisher = "the Institute of Electrical and Electronics Engineers, Inc.",

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Picca, RA, Blasi, D, MacChia, E, Manoli, K, Di Franco, C, Scamarcio, G, Torricelli, F, Zurutuza, A, Napal, I, Centeno, A & Torsi, L 2019, A label-free immunosensor based on a graphene water-gated field-effect transistor. in Proceedings - 2019 8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019., 8791429, Proceedings - 2019 8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019, the Institute of Electrical and Electronics Engineers, Inc., pp. 136-138, 8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019, Otranto, Italy, 13/06/19. https://doi.org/10.1109/IWASI.2019.8791429

A label-free immunosensor based on a graphene water-gated field-effect transistor. / Picca, Rosaria Anna; Blasi, Davide; MacChia, Eleonora et al.
Proceedings - 2019 8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019. the Institute of Electrical and Electronics Engineers, Inc., 2019. p. 136-138 8791429 (Proceedings - 2019 8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019).

Research output: Chapter in Book/Conference proceeding › Published conference proceeding › Scientific › peer-review

TY - GEN

T1 - A label-free immunosensor based on a graphene water-gated field-effect transistor

AU - Picca, Rosaria Anna

AU - Blasi, Davide

AU - MacChia, Eleonora

AU - Manoli, Kyriaki

AU - Di Franco, Cinzia

AU - Scamarcio, Gaetano

AU - Torricelli, Fabrizio

AU - Zurutuza, Amaia

AU - Napal, Ilargi

AU - Centeno, Alba

AU - Torsi, Luisa

N1 - Funding Information: ACKNOWLEDGMENTS The following grants are acknowledged for partial financial support: Regione Puglia - Future in Research − BEND: Biosensori elettronici intelligenti per la diagnosi precoce di malattie neurodegenerative (B164PG8); "SiMoT: Single molecule bio-electronic smart system array for clinical testing" funded by the European Commission under H2020 program, grant #824946; MIUR PON - e-DESIGN: Combination of Design, Electronics and Multifunctional Materials for New Aesthetic Components (ARS01_01158). CSGI is also acknowledged for partial financial support. Publisher Copyright: © 2019 IEEE. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2019/6

Y1 - 2019/6

N2 - Electrolyte-gated graphene field-effect transistors are here proposed for biosensing applications. To this end, a label-free immunosensor based on this technology is employed for the sensitive and selective detection of IgG. Differently from the typical approach based on the bioreceptor immobilization onto a graphene layer, in this work sensitivity in the lower femtomolar range can be reached thanks to the formation of a closely packed layer of anti-IgG receptors anchored to the gold gate electrode.

AB - Electrolyte-gated graphene field-effect transistors are here proposed for biosensing applications. To this end, a label-free immunosensor based on this technology is employed for the sensitive and selective detection of IgG. Differently from the typical approach based on the bioreceptor immobilization onto a graphene layer, in this work sensitivity in the lower femtomolar range can be reached thanks to the formation of a closely packed layer of anti-IgG receptors anchored to the gold gate electrode.

KW - biosensor

KW - electrolyte-gated thin film transistor

KW - gate functionalization

KW - graphene

KW - label-free

UR - https://www.scopus.com/pages/publications/85071444466

U2 - 10.1109/IWASI.2019.8791429

DO - 10.1109/IWASI.2019.8791429

M3 - Published conference proceeding

AN - SCOPUS:85071444466

T3 - Proceedings - 2019 8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019

SP - 136

EP - 138

BT - Proceedings - 2019 8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019

PB - the Institute of Electrical and Electronics Engineers, Inc.

T2 - 8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019

Y2 - 13 June 2019 through 14 June 2019

ER -

Picca RA, Blasi D, MacChia E, Manoli K, Di Franco C, Scamarcio G et al. A label-free immunosensor based on a graphene water-gated field-effect transistor. In Proceedings - 2019 8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019. the Institute of Electrical and Electronics Engineers, Inc. 2019. p. 136-138. 8791429. (Proceedings - 2019 8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019). doi: 10.1109/IWASI.2019.8791429

A label-free immunosensor based on a graphene water-gated field-effect transistor

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Keywords

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