A Comprehensive Review of Patented Technologies to Fabricate Orodispersible Films: Proof of Patent Analysis (2000–2020)

Maram Suresh Gupta, Devegowda Vishakante Gowda, Tegginamath Pramod Kumar, Jessica M. Rosenholm

Research output: Contribution to journalArticleScientificpeer-review

8 Citations (Scopus)
62 Downloads (Pure)

Abstract

Orodispersible films (ODFs)are ultra-thin, stamp-sized, rapidly disintegrating, and attractive oral drug delivery dosage forms best suited for the pediatric and geriatric patient populations.They can be fabricated by different techniques, but the most popular, simple, and industrially applicable technique is the solvent casting method (SCM). In addition, they can also be fabricated by extrusion, printing, electrospinning, and by a combination of these technologies (e.g., SCM + printing). The present review is aimed to provide a comprehensive overview of patented technologies of the last two decades to fabricate ODFs. Through this review, we present evidence to adamantly confirm that SCM is the most popular method while electrospinning is the most recent and upcoming method to fabricate ODFs. We also speculate around the more patent-protected technologies especially in the domain of printing (two or three-dimensional), extrusion (ram or hot-melt extrusion), and electrospinning, or a combination of the methods thereof.
Original languageEnglish
Article number820
Number of pages31
JournalPharmaceutics
Volume14
Issue number4
DOIs
Publication statusPublished - 8 Apr 2022
MoE publication typeA1 Journal article-refereed

Keywords

  • Orodispersible films
  • Solvent casting
  • Printing technologies
  • Electrospinning

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