3D printing of tailored veterinary dual-release tablets: a semi-solid extrusion approach for metoclopramide

Rathna Mathiyalagan; Max Westerlund; Alaa Mahran; Rabia Altunay; Jarkko Suuronen; Mirja Palo; Johan Nyman; Eero  Immonen; Jessica Rosenholm; Erica Monaco; Xiaoju Wang

doi:10.1039/d4pm00322e

3D printing of tailored veterinary dual-release tablets: a semi-solid extrusion approach for metoclopramide

Rathna Mathiyalagan, Max Westerlund, Alaa Mahran, Rabia Altunay, Jarkko Suuronen, Mirja Palo, Johan Nyman, Eero Immonen, Jessica Rosenholm^*, Erica Monaco, Xiaoju Wang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

Metoclopramide (MCP) is frequently used to control nausea and vomiting in animals, but its short half-life requires it to be administered thrice daily. In addition, commercial veterinary MCP formulations are currently lacking. As a result, veterinary practitioners often resort to off-label use of human medications, which can lead to inconsistent patient outcomes and complications arising from inadequate dosing. Thus, there is a growing recognized need for individualized treatment strategies also within veterinary practice, as they can offer tailored doses and improved options for animal patients. To address this unmet need and overcome these challenges, our study focused on developing a once-daily dual-release tailored dose for different-sized cats and dogs utilizing semi-solid extrusion (SSE) 3D printing. The dual-release system containing different cellulosic polymers is designed to provide a rapid onset and sustained action to ensure prolonged drug release and minimize the frequency of administration. The produced printing ink formulations were successfully used to obtain different-sized tailored doses with a significant correlation between the designs and the obtained drug amounts. Dissolution studies revealed the impact of polymer combinations and tablet surface area on drug release profiles. Kinetic modeling indicated that both diffusion and erosion are involved in the release mechanisms. This research emphasizes the practical use of SSE 3D printing in developing dual-release delivery systems by producing precise and pet-friendly tailored tablets to enhance veterinary treatments close to the point-of-care.

Original language	English
Pages (from-to)	413-426
Journal	RSC Pharmaceutics
Volume	2
Issue number	2
DOIs	https://doi.org/10.1039/d4pm00322e
Publication status	Published - 13 Feb 2025
MoE publication type	A1 Journal article-refereed

Funding

The Åbo Akademi University doctoral research grant and Finnish Pharmaceutical Society research grant are greatlyacknowledged for the financial support of Rathna Mathiyalagan. X.W. acknowledges the Research Council/Academy of Finland (#333158) for funding her research at Åbo Akademi University, while J.M.R. acknowledges partial funding from the Business Finland co-innovation project “3D Cure” (575/31/2023). This research is also aligned with the strategic research profiling area “Solutions for Health” at Åbo Akademi University (funded by the Research Council/Academy of Finland, #336355), and parts of the research used the Research Council of Finland funded Research Infrastructure “Printed Intelligence Infrastructure” (PII-FIRI). R. Altunay and J. Suuronen have been funded by the Research Council of Finland through the Flagship of Advanced Mathematics for Sensing, Imaging and Modelling, and the Centre of Excellence of Inverse Modelling and Imaging (decision numbers 359183 and 353095) and Business Finland 3D Cure project (539/31/2023 and 147/31/2023). We thankfully acknowledge Linus Silvander (Åbo Akademi University) for helping with the SEM analysis, Alesja Avramova from Ashland for providing hydroxy-propyl cellulose for this study, and Dhayakumar Rajan Prakash(Brinter AM Technologies Ltd, Turku, Finland), Vishalkumar and Jyoti Verma (Åbo Akademi University) for their hands-on support in the laboratory.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/d4pm00322eLicence: CC BY

d4pm00322eFinal published version, 2.64 MBLicence: CC BY

Åbo Akademi Functional Printing Center
Toivakka, M. (PI), Rosenholm, J. (PI), Anttu, N. (PI), Bobacka, J. (PI), Huynh, T. P. (PI), Peltonen, J. (PI), Wang, X. (PI), Wilen, C.-E. (PI), Xu, C. (PI), Zhang, H. (PI) & Österbacka, R. (PI)
Faculty of Science and Engineering
Facility/equipment: Facility

3D Printing for Personalized Medicine and Customized Drug Delivery
Viitala, T. (Principal Investigator), Rosenholm, J. (Co-Principal Investigator) & Xu, C. (Co-Principal Investigator)
01/05/23 → 31/10/25
Project: Industry/Business Finland
SusCellInk: Sustainable nanocellulose-based bioinks towards diverse material functionalities and therapeutic delivery of bioactive cues
Wang, X. (Principal Investigator)
Research Council of Finland
01/09/20 → 31/08/25
Project: Research Council of Finland/Other Research Councils

Cite this

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title = "3D printing of tailored veterinary dual-release tablets: a semi-solid extrusion approach for metoclopramide",

abstract = "Metoclopramide (MCP) is frequently used to control nausea and vomiting in animals, but its short half-life requires it to be administered thrice daily. In addition, commercial veterinary MCP formulations are currently lacking. As a result, veterinary practitioners often resort to off-label use of human medications, which can lead to inconsistent patient outcomes and complications arising from inadequate dosing. Thus, there is a growing recognized need for individualized treatment strategies also within veterinary practice, as they can offer tailored doses and improved options for animal patients. To address this unmet need and overcome these challenges, our study focused on developing a once-daily dual-release tailored dose for different-sized cats and dogs utilizing semi-solid extrusion (SSE) 3D printing. The dual-release system containing different cellulosic polymers is designed to provide a rapid onset and sustained action to ensure prolonged drug release and minimize the frequency of administration. The produced printing ink formulations were successfully used to obtain different-sized tailored doses with a significant correlation between the designs and the obtained drug amounts. Dissolution studies revealed the impact of polymer combinations and tablet surface area on drug release profiles. Kinetic modeling indicated that both diffusion and erosion are involved in the release mechanisms. This research emphasizes the practical use of SSE 3D printing in developing dual-release delivery systems by producing precise and pet-friendly tailored tablets to enhance veterinary treatments close to the point-of-care.",

author = "Rathna Mathiyalagan and Max Westerlund and Alaa Mahran and Rabia Altunay and Jarkko Suuronen and Mirja Palo and Johan Nyman and Eero Immonen and Jessica Rosenholm and Erica Monaco and Xiaoju Wang",

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AU - Mathiyalagan, Rathna

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AU - Suuronen, Jarkko

AU - Palo, Mirja

AU - Nyman, Johan

AU - Immonen, Eero

AU - Rosenholm, Jessica

AU - Monaco, Erica

AU - Wang, Xiaoju

PY - 2025/2/13

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N2 - Metoclopramide (MCP) is frequently used to control nausea and vomiting in animals, but its short half-life requires it to be administered thrice daily. In addition, commercial veterinary MCP formulations are currently lacking. As a result, veterinary practitioners often resort to off-label use of human medications, which can lead to inconsistent patient outcomes and complications arising from inadequate dosing. Thus, there is a growing recognized need for individualized treatment strategies also within veterinary practice, as they can offer tailored doses and improved options for animal patients. To address this unmet need and overcome these challenges, our study focused on developing a once-daily dual-release tailored dose for different-sized cats and dogs utilizing semi-solid extrusion (SSE) 3D printing. The dual-release system containing different cellulosic polymers is designed to provide a rapid onset and sustained action to ensure prolonged drug release and minimize the frequency of administration. The produced printing ink formulations were successfully used to obtain different-sized tailored doses with a significant correlation between the designs and the obtained drug amounts. Dissolution studies revealed the impact of polymer combinations and tablet surface area on drug release profiles. Kinetic modeling indicated that both diffusion and erosion are involved in the release mechanisms. This research emphasizes the practical use of SSE 3D printing in developing dual-release delivery systems by producing precise and pet-friendly tailored tablets to enhance veterinary treatments close to the point-of-care.

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3D printing of tailored veterinary dual-release tablets: a semi-solid extrusion approach for metoclopramide

Abstract

Funding

UN SDGs

Access to Document

Fingerprint

Equipment

Åbo Akademi Functional Printing Center

Projects

3D Printing for Personalized Medicine and Customized Drug Delivery

SusCellInk: Sustainable nanocellulose-based bioinks towards diverse material functionalities and therapeutic delivery of bioactive cues

Cite this