3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application

Chunlin Xu, Binbin Zhang Molino, Xiaoju Wang, Fang Cheng, Wenyang Xu, Paul Molino, Markus Bacher, Su Dandan, Thomas Rosenau, Stefan Willför, Gordon Wallace

Research output: Contribution to journalArticleScientificpeer-review

123 Citations (Scopus)
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We present for the first time approaches to 3D-printing of nanocellulose hydrogel scaffolds based on double crosslinking, first by in situ Ca2+ crosslinking and post-printing by chemical crosslinking with 1,4-butanediol diglycidyl ether (BDDE). Scaffolds were successfully printed from 1% nanocellulose hydrogels, with their mechanical strength being tunable in the range of 3 to 8 kPa. Cell tests suggest that the 3D-printed and BDDE-crosslinked nanocellulose hydrogel scaffolds supported fibroblast cells' proliferation, which was improving with increasing rigidity. These 3D-printed scaffolds render nanocellulose a new member of the family of promising support structures for crucial cellular processes during wound healing, regeneration and tissue repair.
Original languageUndefined/Unknown
Pages (from-to)7066–7075
Number of pages10
JournalJournal of Materials Chemistry. B
Issue number43
Publication statusPublished - 2018
MoE publication typeA1 Journal article-refereed

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