3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application

Chunlin Xu; Binbin Zhang Molino; Xiaoju Wang; Fang Cheng; Wenyang Xu; Paul Molino; Markus Bacher; Su Dandan; Thomas Rosenau; Stefan Willför; Gordon Wallace

doi:10.1039/c8tb01757c

3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application

Chunlin Xu, Binbin Zhang Molino, Xiaoju Wang, Fang Cheng, Wenyang Xu, Paul Molino, Markus Bacher, Su Dandan, Thomas Rosenau, Stefan Willför, Gordon Wallace

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Abstract

We present for the first time approaches to 3D-printing of nanocellulose hydrogel scaffolds based on double crosslinking, first by in situ Ca²⁺ crosslinking and post-printing by chemical crosslinking with 1,4-butanediol diglycidyl ether (BDDE). Scaffolds were successfully printed from 1% nanocellulose hydrogels, with their mechanical strength being tunable in the range of 3 to 8 kPa. Cell tests suggest that the 3D-printed and BDDE-crosslinked nanocellulose hydrogel scaffolds supported fibroblast cells' proliferation, which was improving with increasing rigidity. These 3D-printed scaffolds render nanocellulose a new member of the family of promising support structures for crucial cellular processes during wound healing, regeneration and tissue repair.

Original language	Undefined/Unknown
Pages (from-to)	7066–7075
Number of pages	10
Journal	Journal of Materials Chemistry. B
Volume	6
Issue number	43
DOIs	https://doi.org/10.1039/c8tb01757c
Publication status	Published - 2018
MoE publication type	A1 Journal article-refereed

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10.1039/c8tb01757c

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title = "3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application",

abstract = "We present for the first time approaches to 3D-printing of nanocellulose hydrogel scaffolds based on double crosslinking, first by in situ Ca2+ crosslinking and post-printing by chemical crosslinking with 1,4-butanediol diglycidyl ether (BDDE). Scaffolds were successfully printed from 1% nanocellulose hydrogels, with their mechanical strength being tunable in the range of 3 to 8 kPa. Cell tests suggest that the 3D-printed and BDDE-crosslinked nanocellulose hydrogel scaffolds supported fibroblast cells' proliferation, which was improving with increasing rigidity. These 3D-printed scaffolds render nanocellulose a new member of the family of promising support structures for crucial cellular processes during wound healing, regeneration and tissue repair.",

author = "Chunlin Xu and {Zhang Molino}, Binbin and Xiaoju Wang and Fang Cheng and Wenyang Xu and Paul Molino and Markus Bacher and Su Dandan and Thomas Rosenau and Stefan Willf{\"o}r and Gordon Wallace",

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TY - JOUR

T1 - 3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application

AU - Xu, Chunlin

AU - Zhang Molino, Binbin

AU - Wang, Xiaoju

AU - Cheng, Fang

AU - Xu, Wenyang

AU - Molino, Paul

AU - Bacher, Markus

AU - Dandan, Su

AU - Rosenau, Thomas

AU - Willför, Stefan

AU - Wallace, Gordon

N1 - 3pk

PY - 2018

Y1 - 2018

N2 - We present for the first time approaches to 3D-printing of nanocellulose hydrogel scaffolds based on double crosslinking, first by in situ Ca2+ crosslinking and post-printing by chemical crosslinking with 1,4-butanediol diglycidyl ether (BDDE). Scaffolds were successfully printed from 1% nanocellulose hydrogels, with their mechanical strength being tunable in the range of 3 to 8 kPa. Cell tests suggest that the 3D-printed and BDDE-crosslinked nanocellulose hydrogel scaffolds supported fibroblast cells' proliferation, which was improving with increasing rigidity. These 3D-printed scaffolds render nanocellulose a new member of the family of promising support structures for crucial cellular processes during wound healing, regeneration and tissue repair.

AB - We present for the first time approaches to 3D-printing of nanocellulose hydrogel scaffolds based on double crosslinking, first by in situ Ca2+ crosslinking and post-printing by chemical crosslinking with 1,4-butanediol diglycidyl ether (BDDE). Scaffolds were successfully printed from 1% nanocellulose hydrogels, with their mechanical strength being tunable in the range of 3 to 8 kPa. Cell tests suggest that the 3D-printed and BDDE-crosslinked nanocellulose hydrogel scaffolds supported fibroblast cells' proliferation, which was improving with increasing rigidity. These 3D-printed scaffolds render nanocellulose a new member of the family of promising support structures for crucial cellular processes during wound healing, regeneration and tissue repair.

U2 - 10.1039/c8tb01757c

DO - 10.1039/c8tb01757c

M3 - Artikel

SN - 2050-750X

VL - 6

SP - 7066

EP - 7075

JO - Journal of Materials Chemistry. B

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