3D-Printed Veterinary Dosage Forms—A Comparative Study of Three Semi-Solid Extrusion 3D Printers

Erica Sjöholm*, Rathna Mathiyalagan, Dhayakumar Rajan Prakash, Lisa Lindfors, Qingbo Wang, Xiaoju Wang, Samuli Ojala, Niklas Sandler

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)

Abstract

Currently, the number of approved veterinary medicines are limited, and human medications are used off-label. These approved human medications are of too high potencies for a cat or a small dog breed. Therefore, there is a dire demand for smaller doses of veterinary medicines. This study aims to investigate the use of three semi-solid extrusion 3D printers in a pharmacy or animal clinic setting for the extemporaneous manufacturing of prednisolone containing orodispersible films for veterinary use. Orodispersible films with adequate content uniformity and acceptance values as defined by the European Pharmacopoeia were produced with one of the studied printers, namely the Allevi 2 bioprinter. Smooth and flexible films with high mechanical strength, neutral pH, and low moisture content were produced with a high correlation between the prepared design and the obtained drug amount, indicating that the Allevi 2 printer could successfully be used to extemporaneously manufacture personalized doses for animals at the point-of-care.
Original languageEnglish
Article number1239
Pages (from-to)1-26
JournalPharmaceutics
Volume12
Issue number12
DOIs
Publication statusPublished - 19 Dec 2020
MoE publication typeA1 Journal article-refereed

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