3D label free bio-transfer standards

Miikka Järvinen; Tuomas Vainikka; Tapani Viitala; Carlos Bermudez; Roger Artigas; Anton Nolvi; Pol Martinez; Niklas Sandler; Edward Hæggström; Ivan Kassamakov

doi:10.1117/12.2501258

3D label free bio-transfer standards

Miikka Järvinen
, Tuomas Vainikka
, Tapani Viitala
, Carlos Bermudez
, Roger Artigas
, Anton Nolvi
, Pol Martinez
, Niklas Sandler
, Edward Hæggström
, Ivan Kassamakov^*

^*Corresponding author for this work

Research output: Chapter in Book/Conference proceeding › Published conference proceeding › Scientific › peer-review

Abstract

Two kinds of 3D label free Bio-Transfer-Standards (BTS) have been further developed at the University of Helsinki (UH). The first one, NanoRuler, is a staircase BTS featuring eight fatty acid bilayers which allows vertical calibration in the range of 5 to 40 nm. The second one, NanoStar, is a V-shaped BTS featuring two 5 nm tall bilayers that overlap at 10° angle. This standard enables the determination of the Instrument Transfer Function (ITF). A stability test was conducted on the BTSs, during which the standards were stored in laboratory conditions, and were profiled each week. Profiling was done using a custom-built Scanning White Light Interferometer (SWLI). The stability of NanoStar was ± 0.3 nm, and of NanoRuler ± 0.5 nm to ± 2.5 nm. The BTSs maintained their specified properties for at least six months and therefore allow vertical calibration and ITF determination. In addition, changes in surface morphology of one NanoRuler subjected to water immersion are presented. This paper reports intermediate findings during an ongoing stability test that will run for 24 months.

Original language	English
Title of host publication	Optical Metrology and Inspection for Industrial Applications V
Editors	Toru Yoshizawa, Song Zhang, Sen Han, Sen Han
Publisher	SPIE, The International Society for Optical Engineering
ISBN (Electronic)	9781510622364
ISBN (Print)	9781510622364
DOIs	https://doi.org/10.1117/12.2501258
Publication status	Published - 2018
MoE publication type	A4 Article in a conference publication
Event	Optical Metrology and Inspection for Industrial Applications V 2018 - Beijing, China Duration: 11 Oct 2018 → 13 Oct 2018

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	10819
ISSN (Print)	0277-786X
ISSN (Electronic)	1996-756X

Conference

Conference	Optical Metrology and Inspection for Industrial Applications V 2018
Country/Territory	China
City	Beijing
Period	11/10/18 → 13/10/18

Keywords

Bio transfer standard
Instrument Transfer Function
Nanometer scale metrology
Optical profiler
Scanning White Light Interferometry

Access to Document

10.1117/12.2501258

Cite this

Järvinen, M., Vainikka, T., Viitala, T., Bermudez, C., Artigas, R., Nolvi, A., Martinez, P., Sandler, N., Hæggström, E., & Kassamakov, I. (2018). 3D label free bio-transfer standards. In T. Yoshizawa, S. Zhang, S. Han, & S. Han (Eds.), Optical Metrology and Inspection for Industrial Applications V Article 108190D (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 10819). SPIE, The International Society for Optical Engineering. https://doi.org/10.1117/12.2501258

@inproceedings{e330034b6e7644718bf07435808960ad,

title = "3D label free bio-transfer standards",

abstract = "Two kinds of 3D label free Bio-Transfer-Standards (BTS) have been further developed at the University of Helsinki (UH). The first one, NanoRuler, is a staircase BTS featuring eight fatty acid bilayers which allows vertical calibration in the range of 5 to 40 nm. The second one, NanoStar, is a V-shaped BTS featuring two 5 nm tall bilayers that overlap at 10° angle. This standard enables the determination of the Instrument Transfer Function (ITF). A stability test was conducted on the BTSs, during which the standards were stored in laboratory conditions, and were profiled each week. Profiling was done using a custom-built Scanning White Light Interferometer (SWLI). The stability of NanoStar was ± 0.3 nm, and of NanoRuler ± 0.5 nm to ± 2.5 nm. The BTSs maintained their specified properties for at least six months and therefore allow vertical calibration and ITF determination. In addition, changes in surface morphology of one NanoRuler subjected to water immersion are presented. This paper reports intermediate findings during an ongoing stability test that will run for 24 months.",

keywords = "Bio transfer standard, Instrument Transfer Function, Nanometer scale metrology, Optical profiler, Scanning White Light Interferometry",

author = "Miikka J{\"a}rvinen and Tuomas Vainikka and Tapani Viitala and Carlos Bermudez and Roger Artigas and Anton Nolvi and Pol Martinez and Niklas Sandler and Edward H{\ae}ggstr{\"o}m and Ivan Kassamakov",

note = "Publisher Copyright: {\textcopyright} 2018 SPIE.; Optical Metrology and Inspection for Industrial Applications V 2018 ; Conference date: 11-10-2018 Through 13-10-2018",

year = "2018",

doi = "10.1117/12.2501258",

language = "English",

isbn = "9781510622364",

series = "Proceedings of SPIE - The International Society for Optical Engineering",

publisher = "SPIE, The International Society for Optical Engineering",

editor = "Toru Yoshizawa and Song Zhang and Sen Han and Sen Han",

booktitle = "Optical Metrology and Inspection for Industrial Applications V",

}

Järvinen, M, Vainikka, T, Viitala, T, Bermudez, C, Artigas, R, Nolvi, A, Martinez, P, Sandler, N, Hæggström, E & Kassamakov, I 2018, 3D label free bio-transfer standards. in T Yoshizawa, S Zhang, S Han & S Han (eds), Optical Metrology and Inspection for Industrial Applications V., 108190D, Proceedings of SPIE - The International Society for Optical Engineering, vol. 10819, SPIE, The International Society for Optical Engineering, Optical Metrology and Inspection for Industrial Applications V 2018, Beijing, China, 11/10/18. https://doi.org/10.1117/12.2501258

3D label free bio-transfer standards. / Järvinen, Miikka; Vainikka, Tuomas; Viitala, Tapani et al.
Optical Metrology and Inspection for Industrial Applications V. ed. / Toru Yoshizawa; Song Zhang; Sen Han; Sen Han. SPIE, The International Society for Optical Engineering, 2018. 108190D (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 10819).

Research output: Chapter in Book/Conference proceeding › Published conference proceeding › Scientific › peer-review

TY - GEN

T1 - 3D label free bio-transfer standards

AU - Järvinen, Miikka

AU - Vainikka, Tuomas

AU - Viitala, Tapani

AU - Bermudez, Carlos

AU - Artigas, Roger

AU - Nolvi, Anton

AU - Martinez, Pol

AU - Sandler, Niklas

AU - Hæggström, Edward

AU - Kassamakov, Ivan

PY - 2018

Y1 - 2018

N2 - Two kinds of 3D label free Bio-Transfer-Standards (BTS) have been further developed at the University of Helsinki (UH). The first one, NanoRuler, is a staircase BTS featuring eight fatty acid bilayers which allows vertical calibration in the range of 5 to 40 nm. The second one, NanoStar, is a V-shaped BTS featuring two 5 nm tall bilayers that overlap at 10° angle. This standard enables the determination of the Instrument Transfer Function (ITF). A stability test was conducted on the BTSs, during which the standards were stored in laboratory conditions, and were profiled each week. Profiling was done using a custom-built Scanning White Light Interferometer (SWLI). The stability of NanoStar was ± 0.3 nm, and of NanoRuler ± 0.5 nm to ± 2.5 nm. The BTSs maintained their specified properties for at least six months and therefore allow vertical calibration and ITF determination. In addition, changes in surface morphology of one NanoRuler subjected to water immersion are presented. This paper reports intermediate findings during an ongoing stability test that will run for 24 months.

AB - Two kinds of 3D label free Bio-Transfer-Standards (BTS) have been further developed at the University of Helsinki (UH). The first one, NanoRuler, is a staircase BTS featuring eight fatty acid bilayers which allows vertical calibration in the range of 5 to 40 nm. The second one, NanoStar, is a V-shaped BTS featuring two 5 nm tall bilayers that overlap at 10° angle. This standard enables the determination of the Instrument Transfer Function (ITF). A stability test was conducted on the BTSs, during which the standards were stored in laboratory conditions, and were profiled each week. Profiling was done using a custom-built Scanning White Light Interferometer (SWLI). The stability of NanoStar was ± 0.3 nm, and of NanoRuler ± 0.5 nm to ± 2.5 nm. The BTSs maintained their specified properties for at least six months and therefore allow vertical calibration and ITF determination. In addition, changes in surface morphology of one NanoRuler subjected to water immersion are presented. This paper reports intermediate findings during an ongoing stability test that will run for 24 months.

KW - Bio transfer standard

KW - Instrument Transfer Function

KW - Nanometer scale metrology

KW - Optical profiler

KW - Scanning White Light Interferometry

UR - https://www.scopus.com/pages/publications/85059394584

U2 - 10.1117/12.2501258

DO - 10.1117/12.2501258

M3 - Published conference proceeding

SN - 9781510622364

T3 - Proceedings of SPIE - The International Society for Optical Engineering

BT - Optical Metrology and Inspection for Industrial Applications V

A2 - Yoshizawa, Toru

A2 - Zhang, Song

A2 - Han, Sen

PB - SPIE, The International Society for Optical Engineering

T2 - Optical Metrology and Inspection for Industrial Applications V 2018

Y2 - 11 October 2018 through 13 October 2018

ER -

Järvinen M, Vainikka T, Viitala T, Bermudez C, Artigas R, Nolvi A et al. 3D label free bio-transfer standards. In Yoshizawa T, Zhang S, Han S, Han S, editors, Optical Metrology and Inspection for Industrial Applications V. SPIE, The International Society for Optical Engineering. 2018. 108190D. (Proceedings of SPIE - The International Society for Optical Engineering). doi: 10.1117/12.2501258

3D label free bio-transfer standards

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