The integration of Cell signalling and mechanical forces in vascular morphology

Research output

Research output per year 2018 2018 2019 2020 2021 2022 2023 2023

• 10 Article
• 7 Review Article or Literature Review

Research output per year

Research output per year

Search results

• 2023

  A multiscale computational model of arterial growth and remodeling including Notch signaling

  van Asten, J. G. M., Latorre, M., Karakaya, C., Baaijens, F. P. T., Sahlgren, C. M., Ristori, T., Humphrey, J. D. & Loerakker, S., 6 Apr 2023, (E-pub ahead of print) In: Biomechanics and modeling in mechanobiology.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Notch 100%
  • Notch Signaling 16%
  • Growth 16%
  • Model 16%
  • Notch Signaling Pathway 16%
  9 Downloads (Pure)
• 2022

  Computational analysis of the role of mechanosensitive Notch signaling in arterial adaptation to hypertension

  van Asten, J. G. M., Ristori, T., Nolan, D. R., Lally, C., Baaijens, F. P. T., Sahlgren, C. M. & Loerakker, S., Sept 2022, In: Journal of the Mechanical Behavior of Biomedical Materials. 133, p. 105325 105325.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Notch 100%
  • Hypertension 33%
  • Notch Signaling 25%
  • Arterial Wall Thickening 25%
  • Notch Signaling Pathway 25%
  1 Citation (Scopus)

  11 Downloads (Pure)

• Engineered patterns of Notch ligands Jag1 and Dll4 elicit differential spatial control of endothelial sprouting

  Tiemeijer, L., Ristori, T., Stassen, O., Ahlberg, J., de Bijl, J. J. J., Chen, C. S., Bentley, K., Bouten, C. V. C. & Sahlgren, C., 20 May 2022, In: iScience. 25, 5, 104306.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Notch 100%
  • Ligand 25%
  • Sprouting 18%
  • Regulatory Mechanism 18%
  • Angiogenesis 12%
  3 Citations (Scopus)

  27 Downloads (Pure)

• Notch signaling regulates strain-mediated phenotypic switching of vascular smooth muscle cells

  Karakaya, C., Van Turnhout, M. C., Visser, V. L., Ristori, T., Bouten, C. V. C., Sahlgren, C. M. & Loerakker, S., 2022, In: Frontiers in Cell and Developmental Biology. 10

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Vascular Smooth Muscle Cell 100%
  • Cell 100%
  • Notch Signaling 80%
  • Notch Signaling Pathway 80%
  • Strain 60%
  2 Citations (Scopus)

  43 Downloads (Pure)
• 2020

  Computational characterization of the dish-in-a-dish, a high yield culture platform for endothelial shear stress studies on the orbital shaker

  Driessen, R., Zhao, F., Hofmann, S., Bouten, C., Sahlgren, C. & Stassen, O., 1 Jun 2020, In: Micromachines. 11, 6, 552.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Shears 100%
  • Orbitals 30%
  • Independent Variables 30%
  • Speed 20%
  • Gene Expression 10%
  8 Citations (Scopus)

  21 Downloads (Pure)

• Lateral induction limits the impact of cell connectivity on Notch signaling in arterial walls

  Ristori, T., Stassen, O. M. J. A., Sahlgren, C. M. & Loerakker, S., 2020, In: International Journal for Numerical Methods in Biomedical Engineering. 36, 4, e3323.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Notch 100%
  • Cells 41%
  • Phenotype 20%
  • Dynamics 16%
  • Connectivity 16%
  8 Citations (Scopus)

  9 Downloads (Pure)
• 2019

  Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress.

  van Engeland, N. C. A., Suarez Rodriguez, F., Rivero-Müller, A., Ristori, T., Duran, C. L., Stassen, O. M. J. A., Antfolk, D., Driessen, R. C. H., Ruohonen, S., Ruohonen, S. T., Nuutinen, S., Savontaus, E., Loerakker, S., Bayless, K. J., Sjöqvist, M., Bouten, C. V. C., Eriksson, J. E. & Sahlgren, C. M., 2019, In: Scientific Reports. 9, p. –

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
  50 Citations (Scopus)

  15 Downloads (Pure)
• 2018

  A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions

  van Engeland, N., A. O. Pollet, A. M., J. den Toonder, J. M., C. Bouten, C. V., Stassen, O. & Sahlgren, C., 2018, In: Lab on a Chip. 18, 11, p. 1607–1620 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
  67 Citations (Scopus)

  18 Downloads (Pure)

• Mechanosensitivity of Jagged-Notch signaling can induce a switch-type behavior in vascular homeostasis

  Loerakker, S., Stassen, O., ter Huurne, F. M., Boareto, M., C. Bouten, C. V. & Sahlgren, C., 2018, In: Proceedings of the National Academy of Sciences. 115, 16, p. E3682–E3691 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
  41 Citations (Scopus)

  9 Downloads (Pure)

• Shear stress induces expression, intracellular reorganization and enhanced Notch activation potential of Jagged1

  RCH, D., Stassen, O., Sjöqvist, M., Suarez Rodriguez, F., Grolleman, J., CVC, B. & Sahlgren, C., 2018, In: Integrative Biology. 10, 11, p. 719–726 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
  23 Citations (Scopus)

  32 Downloads (Pure)