The integration of Cell signalling and mechanical forces in vascular morphology

Research output

Research output per year 2018 2018 2019 2020 2021 2022 2023 2023

• 10 Article
• 7 Review Article or Literature Review

Research output per year

Research output per year

Search results

• 2023

  A multiscale computational model of arterial growth and remodeling including Notch signaling

  van Asten, J. G. M., Latorre, M., Karakaya, C., Baaijens, F. P. T., Sahlgren, C. M., Ristori, T., Humphrey, J. D. & Loerakker, S., 6 Apr 2023, (E-pub ahead of print) In: Biomechanics and modeling in mechanobiology.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Notch 100%
  • Notch Signaling 16%
  • Growth 16%
  • Model 16%
  • Notch Signaling Pathway 16%
  9 Downloads (Pure)

• Organ‐on‐a‐chip technologies for biomedical research and drug development: A focus on the vasculature

  Soto veliz, D., Lin, K-L. & Sahlgren, C., 1 Feb 2023, In: Smart Medicine. 2, 1

  Research output: Contribution to journal › Review Article or Literature Review › peer-review

  Open Access

  File
  213 Downloads (Pure)
• 2022

  Computational analysis of the role of mechanosensitive Notch signaling in arterial adaptation to hypertension

  van Asten, J. G. M., Ristori, T., Nolan, D. R., Lally, C., Baaijens, F. P. T., Sahlgren, C. M. & Loerakker, S., Sept 2022, In: Journal of the Mechanical Behavior of Biomedical Materials. 133, p. 105325 105325.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Notch 100%
  • Hypertension 33%
  • Notch Signaling 25%
  • Arterial Wall Thickening 25%
  • Notch Signaling Pathway 25%
  1 Citation (Scopus)

  11 Downloads (Pure)

• Engineered patterns of Notch ligands Jag1 and Dll4 elicit differential spatial control of endothelial sprouting

  Tiemeijer, L., Ristori, T., Stassen, O., Ahlberg, J., de Bijl, J. J. J., Chen, C. S., Bentley, K., Bouten, C. V. C. & Sahlgren, C., 20 May 2022, In: iScience. 25, 5, 104306.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Notch 100%
  • Ligand 25%
  • Sprouting 18%
  • Regulatory Mechanism 18%
  • Angiogenesis 12%
  3 Citations (Scopus)

  27 Downloads (Pure)

• Engineering tissue morphogenesis: taking it up a Notch

  Tiemeijer, L. A., Sanlidag, S., Bouten, C. V. C. & Sahlgren, C., Aug 2022, In: Trends in Biotechnology. 40, 8, p. 945-957 13 p.

  Research output: Contribution to journal › Review Article or Literature Review › peer-review

  Open Access

  File

  • Notch 100%
  • Tissues 50%
  • Cell Fate 33%
  • Morphogenesis 33%
  • Notch Signaling 16%
  4 Citations (Scopus)

  9 Downloads (Pure)

• Notch signaling regulates strain-mediated phenotypic switching of vascular smooth muscle cells

  Karakaya, C., Van Turnhout, M. C., Visser, V. L., Ristori, T., Bouten, C. V. C., Sahlgren, C. M. & Loerakker, S., 2022, In: Frontiers in Cell and Developmental Biology. 10

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Vascular Smooth Muscle Cell 100%
  • Cell 100%
  • Notch Signaling 80%
  • Notch Signaling Pathway 80%
  • Strain 60%
  2 Citations (Scopus)

  43 Downloads (Pure)
• 2021

  Ex vivo models to decipher the molecular mechanisms of genetic Notch cardiovascular disorders

  Ristori, T., Sjöqvist, M. & Sahlgren, C. M., Mar 2021, In: Tissue Engineering Part C Methods. 27, 3, p. 167-176

  Research output: Contribution to journal › Review Article or Literature Review › peer-review

  Open Access

  File

  • Notch 100%
  • Cardiovascular Disease 37%
  • Signal Transduction 25%
  • Homeostasis 12%
  • Diseases 12%
  2 Citations (Scopus)

  11 Downloads (Pure)

• Mechano-regulated cell–cell signaling in the context of cardiovascular tissue engineering

  Karakaya, C., van Asten, J. G. M., Ristori, T., Sahlgren, C. M. & Loerakker, S., 2021, In: Biomechanics and Modeling in Mechanobiology. 21

  Research output: Contribution to journal › Review Article or Literature Review › peer-review

  Open Access

  File

  • Cardiovascular Tissue 100%
  • Cardiovascular Tissue Engineering 75%
  • Tissues 62%
  • Comprehension 37%
  • Engineered Tissue 37%
  4 Citations (Scopus)

  41 Downloads (Pure)
• 2020

  Computational characterization of the dish-in-a-dish, a high yield culture platform for endothelial shear stress studies on the orbital shaker

  Driessen, R., Zhao, F., Hofmann, S., Bouten, C., Sahlgren, C. & Stassen, O., 1 Jun 2020, In: Micromachines. 11, 6, 552.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Shears 100%
  • Orbitals 30%
  • Independent Variables 30%
  • Speed 20%
  • Gene Expression 10%
  8 Citations (Scopus)

  21 Downloads (Pure)

• From structural resilience to cell specification - Intermediate filaments as regulators of cell fate

  Sjöqvist, M., Antfolk, D., Suarez-Rodriguez, F. & Sahlgren, C., 2020, In: FASEB Journal. 35, 1, e21182.

  Research output: Contribution to journal › Review Article or Literature Review › peer-review

  Open Access

  File

  • Intermediate Filament 100%
  • Stem Cell 50%
  • Signal Transduction 40%
  • Diseases 20%
  • Cell Differentiation 20%
  4 Citations (Scopus)

  36 Downloads (Pure)

• Lateral induction limits the impact of cell connectivity on Notch signaling in arterial walls

  Ristori, T., Stassen, O. M. J. A., Sahlgren, C. M. & Loerakker, S., 2020, In: International Journal for Numerical Methods in Biomedical Engineering. 36, 4, e3323.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Notch 100%
  • Cells 41%
  • Phenotype 20%
  • Dynamics 16%
  • Connectivity 16%
  8 Citations (Scopus)

  9 Downloads (Pure)

• Notch in mechanotransduction – from molecular mechanosensitivity to tissue mechanostasis

  Stassen, O. M. J. A., Ristori, T. & Sahlgren, C. M., 21 Dec 2020, In: Journal of Cell Science. 133, 24, 14 p., jcs250738.

  Research output: Contribution to journal › Review Article or Literature Review › peer-review

  Open Access

  File

  • Notch 100%
  • Association 75%
  • Mechanics 75%
  • Cell Fate 50%
  • Notch Signaling Pathway 50%
  30 Citations (Scopus)

  29 Downloads (Pure)
• 2019

  Decoding the PTM-switchboard of Notch

  Antfolk, D., Antila, C., Kemppainen, K., Landor, S. K-J. & Sahlgren, C., 2019, In: Biochimica et biophysica acta. Molecular cell research. 1866, p. –

  Research output: Contribution to journal › Review Article or Literature Review › peer-review

  Open Access

  File
  19 Citations (Scopus)

  27 Downloads (Pure)

• Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress.

  van Engeland, N. C. A., Suarez Rodriguez, F., Rivero-Müller, A., Ristori, T., Duran, C. L., Stassen, O. M. J. A., Antfolk, D., Driessen, R. C. H., Ruohonen, S., Ruohonen, S. T., Nuutinen, S., Savontaus, E., Loerakker, S., Bayless, K. J., Sjöqvist, M., Bouten, C. V. C., Eriksson, J. E. & Sahlgren, C. M., 2019, In: Scientific Reports. 9, p. –

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
  50 Citations (Scopus)

  15 Downloads (Pure)
• 2018

  A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions

  van Engeland, N., A. O. Pollet, A. M., J. den Toonder, J. M., C. Bouten, C. V., Stassen, O. & Sahlgren, C., 2018, In: Lab on a Chip. 18, 11, p. 1607–1620 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
  67 Citations (Scopus)

  18 Downloads (Pure)

• Mechanosensitivity of Jagged-Notch signaling can induce a switch-type behavior in vascular homeostasis

  Loerakker, S., Stassen, O., ter Huurne, F. M., Boareto, M., C. Bouten, C. V. & Sahlgren, C., 2018, In: Proceedings of the National Academy of Sciences. 115, 16, p. E3682–E3691 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
  41 Citations (Scopus)

  9 Downloads (Pure)

• Shear stress induces expression, intracellular reorganization and enhanced Notch activation potential of Jagged1

  RCH, D., Stassen, O., Sjöqvist, M., Suarez Rodriguez, F., Grolleman, J., CVC, B. & Sahlgren, C., 2018, In: Integrative Biology. 10, 11, p. 719–726 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
  23 Citations (Scopus)

  32 Downloads (Pure)