Notch counteracts replication stress to prevent cancer cell senescence

Sahlgren, Cecilia (Principal Investigator)

Status	Finished
Effective start/end date	01/05/20 → 31/12/23

Funding

Cancer Foundation Finland
Sigrid Jusélius Foundation

Keywords

Notch signaling
replication stress
cancer
cell senescence

5 Article
2 Review Article or Literature Review

Investigating Spectral Biomarker Candidates for Migratory Potential in Cancer Cells Using Micro-FTIR and O-PTIR Spectroscopy
Holub, E., Hondl, N., Lin, K.-L., Parikainen, M., Sahlgren, C., Lendl, B. & Ramer, G., 18 Feb 2026, In: ACS Measurement Science Au. 6, 1, p. 96-106
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
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4 Citations (Scopus)

64 Downloads (Pure)
Jagged1 regulates extracellular matrix deposition and remodeling in triple-negative breast cancer
Parikainen, M., Suwal, U., Rappu, P., Heino, J. & Sahlgren, C., 18 Mar 2026, In: Science Advances. 12, 12
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
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4 Citations (Scopus)

31 Downloads (Pure)
Germline-specific RNA helicase DDX4 forms cytoplasmic granules in cancer cells and promotes tumor growth
Olotu, O., Koskenniemi, A.-R., Ma, L., Paramonov, V., Laasanen, S., Louramo, E., Bourgery, M., Lehtiniemi, T., Laasanen, S., Rivero-Müller, A., Löyttyniemi, E., Sahlgren, C., Westermarck, J., Ventelä, S., Visakorpi, T., Poutanen, M., Vainio, P., Mäkelä, J.-A. & Kotaja, N., 23 Jul 2024, In: Cell Reports. 43, 7, 32 p., 114430.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
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7 Citations (Scopus)

172 Downloads (Pure)

The Notch ligand Jagged1 regulates extracellular matrix production and organization in triple-negative breast cancer
Parikainen, M. (Creator), Suwal, U. (Creator), Rappu, P. (Creator), Jyrki, H. (Creator) & Sahlgren, C. (Creator), NCBI, 9 Feb 2026
DOI: GSE296927, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE296927
Dataset

OptoNotch: Using light to activate Notch signaling
Kałafut, J., Czapiński, J., Przybyszewska-Podstawka, A., Czerwonka, A., Odrzywolski, A., Sahlgren, C. & Rivero Müller, A.
20/05/22
1 Media contribution
Press/Media: Social Media Activity/Appearance
New Research Data on the Regulation of Hormone-dependent Breast Cancer
Sahlgren, C., Koskinen, P. J., Santio, N. M. & Landor, S.
22/04/21
1 Media contribution
Press/Media
Nya forskningsrön om regleringen av hormonell bröstcancer
Sahlgren, C., Landor, S., Santio, N. M. & Koskinen, P. J.
22/04/21
1 Media contribution
Press/Media