Notch counteracts replication stress to prevent cancer cell senescence

Sahlgren, Cecilia (Principal Investigator)

Status	Finished
Effective start/end date	01/05/20 → 31/12/23

Funding

Cancer Foundation Finland
Sigrid Jusélius Foundation

Keywords

Notch signaling
replication stress
cancer
cell senescence

3 Article
2 Review Article or Literature Review

Germline-specific RNA helicase DDX4 forms cytoplasmic granules in cancer cells and promotes tumor growth
Olotu, O., Koskenniemi, A.-R., Ma, L., Paramonov, V., Laasanen, S., Louramo, E., Bourgery, M., Lehtiniemi, T., Laasanen, S., Rivero-Müller, A., Löyttyniemi, E., Sahlgren, C., Westermarck, J., Ventelä, S., Visakorpi, T., Poutanen, M., Vainio, P., Mäkelä, J.-A. & Kotaja, N., 23 Jul 2024, In: Cell Reports. 43, 7, 32 p., 114430.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
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5 Citations (Scopus)

60 Downloads (Pure)
Modulating epigenetic modifications for cancer therapy (Review)
Castro-Muñoz, L. J., Ulloa, E. V., Sahlgren, C., Lizano, M., De La Cruz-Hernández, E. & Contreras-Paredes, A., Mar 2023, In: Oncology Reports. 49, 3, 59.
Research output: Contribution to journal › Review Article or Literature Review › peer-review

Open Access
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71 Citations (Scopus)

200 Downloads (Pure)
GIT1 protects against breast cancer growth through negative regulation of Notch
Zhang, S., Miyakawa, A., Wickström, M., Dyberg, C., Louhivuori, L., Varas-godoy, M., Kemppainen, K., Kanatani, S., Kaczynska, D., Ellström, I. D., Elfman, L., Kronqvist, P., Repo, H., Mikoshiba, K., Sahlgren, C., Johnsen, J. I. & Uhlén, P., 22 Mar 2022, In: Nature Communications. 13, 1, 1537.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
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13 Citations (Scopus)

55 Downloads (Pure)

OptoNotch: Using light to activate Notch signaling
Kałafut, J., Czapiński, J., Przybyszewska-Podstawka, A., Czerwonka, A., Odrzywolski, A., Sahlgren, C. & Rivero Müller, A.
20/05/22
1 Media contribution
Press/Media: Social Media Activity/Appearance
New Research Data on the Regulation of Hormone-dependent Breast Cancer
Sahlgren, C., Koskinen, P. J., Santio, N. M. & Landor, S.
22/04/21
1 Media contribution
Press/Media
Nya forskningsrön om regleringen av hormonell bröstcancer
Sahlgren, C., Landor, S., Santio, N. M. & Koskinen, P. J.
22/04/21
1 Media contribution
Press/Media