Project Details
Description
Disturbed proteostasis may contribute to Parkinson’s disesase where deficient clearance of misfolded alpha-synuclein contributes to the pathology. Cells under stress are affected by this by a variety of mechanisms. From translational infidelity to usage of alternative start sites, the resulting protein aberrancies remain undetected by standard proteomics methods. This project will apply new methods to re-analyse existing proteomic data from Parkinson’s patient cohorts to uncover hidden proteome aberrancies within.
Short title | MJFF Datascience |
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Status | Active |
Effective start/end date | 01/06/22 → 31/01/24 |
Funding
- Michael J. Fox Foundation: €287,071.00