Center of Excellence in Cellular Mechanostasis

Research output

Research output per year 2018 2020 2021 2022 2023

• 19 Article
• 11 Review Article or Literature Review
• 2 Performance
• 1 Chapter

Research output per year

Research output per year

Search results

• 2023

  A multiscale computational model of arterial growth and remodeling including Notch signaling

  van Asten, J. G. M., Latorre, M., Karakaya, C., Baaijens, F. P. T., Sahlgren, C. M., Ristori, T., Humphrey, J. D. & Loerakker, S., 6 Apr 2023, (E-pub ahead of print) In: Biomechanics and modeling in mechanobiology.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Notch 100%
  • Notch Signaling 16%
  • Growth 16%
  • Model 16%
  • Notch Signaling Pathway 16%
  1 Citation (Scopus)

  36 Downloads (Pure)
• 2022

  An N-glycan on the C2 domain of JAGGED1 is important for Notch activation

  Meng, Y., Sanlidag, S., Jensen, S. A., Burnap, S. A., Struwe, W. B., Larsen, A. H., Feng, X., Mittal, S., Sansom, M. S. P., Sahlgren, C. & Handford, P. A., 11 Oct 2022, In: Science Signaling. 15, 755, eabo3507.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Polysaccharides 100%
  • Notch 87%
  • C2 Domain 62%
  • Glycosylation 37%
  • N-Terminus 25%
  3 Citations (Scopus)

  23 Downloads (Pure)

• Colonocyte keratin 7 is expressed de novo in inflammatory bowel diseases and associated with pathological changes and drug-resistance

  Polari, L., Tenhami, M., Anttila, S., Helenius, T., Kujari, H., Kallajoki, M., Voutilainen, M. & Toivola, D. M., 23 Dec 2022, In: Scientific Reports. 12, 1, 10 p., 22213.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Keratin 7 100%
  • Inflammatory Bowel Disease 60%
  • Epithelium 20%
  • Biological Marker 20%
  • Colon 20%
  3 Citations (Scopus)

  9 Downloads (Pure)

• Engineered patterns of Notch ligands Jag1 and Dll4 elicit differential spatial control of endothelial sprouting

  Tiemeijer, L., Ristori, T., Stassen, O., Ahlberg, J., de Bijl, J. J. J., Chen, C. S., Bentley, K., Bouten, C. V. C. & Sahlgren, C., 20 May 2022, In: iScience. 25, 5, 104306.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Notch 100%
  • Ligand 25%
  • Sprouting 18%
  • Regulatory Mechanism 18%
  • Angiogenesis 12%
  7 Citations (Scopus)

  52 Downloads (Pure)

• GIT1 protects against breast cancer growth through negative regulation of Notch

  Zhang, S., Miyakawa, A., Wickström, M., Dyberg, C., Louhivuori, L., Varas-godoy, M., Kemppainen, K., Kanatani, S., Kaczynska, D., Ellström, I. D., Elfman, L., Kronqvist, P., Repo, H., Mikoshiba, K., Sahlgren, C., Johnsen, J. I. & Uhlén, P., 1 Dec 2022, In: Nature Communications. 13, 1, 1537.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Notch 100%
  • GIT1 100%
  • Notch Signaling Pathway 42%
  • Growth 28%
  • Regulatory Mechanism 28%
  8 Citations (Scopus)

  14 Downloads (Pure)

• Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon

  Stenvall, C-G. A., Tayyab, M., Grönroos, T. J., Ilomäki, M. A., Viiri, K., Ridge, K. M., Polari, L. & Toivola, D. M., Jan 2022, In: Cellular and Molecular Life Sciences. 79, 1, 17 p., 10.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Keratin 8 100%
  • Colon 60%
  • Mouse 40%
  • Epithelial Cell 30%
  • Carcinogenesis 20%
  11 Citations (Scopus)

  26 Downloads (Pure)
• 2021

  Avoiding a replication crisis in deep-learning-based bioimage analysis

  Laine, R. F., Arganda-Carreras, I., Henriques, R. & Jacquemet, G., Oct 2021, In: Nature Methods. 18, p. 1136-1144

  Research output: Contribution to journal › Article › Scientific

  Open Access
  43 Citations (Scopus)

• Drice restrains Diap2-mediated inflammatory signalling and intestinal inflammation

  Kietz, C., Mohan, A. K., Pollari, V., Tuominen, I-E., Ribeiro, P. S., Meier, P. & Meinander, A., 2021, In: Cell Death and Differentiation. 29, 28-39

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access
  7 Citations (Scopus)

• Keratin 7 Is a Constituent of the Keratin Network in Mouse Pancreatic Islets and Is Upregulated in Experimental Diabetes

  Alam, C. M., Baghestani, S., Pajari, A., Omary, M. B. & Toivola, D. M., 21 Jul 2021, In: International Journal of Molecular Sciences. 22, 15, p. 1-16 16 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  • K 18 100%
  • Keratin 57%
  • Cells 57%
  • Experimental Diabetes Mellitus 28%
  • Pancreatic Islet 28%
  6 Citations (Scopus)

• PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion

  Landor, S. K. J., Santio, N. M., Eccleshall, W. B., Paramonov, V. M., Gagliani, E. K., Hall, D., Jin, S-B., Dahlström, K. M., Salminen, T. A., Rivero-Müller, A., Lendahl, U., Kovall, R. A., Koskinen, P. J. & Sahlgren, C., 2021, In: Journal of Biological Chemistry. 296, 100593.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Phosphorylation 100%
  • Breast Cancer 100%
  • Notch 75%
  • Phosphotransferase 50%
  • Carcinogenicity 50%
  8 Citations (Scopus)

  94 Downloads (Pure)

• Sensitization of MCF7 Cells with High Notch1 Activity by Cisplatin and Histone Deacetylase Inhibitors Applied Together

  Wawruszak, A., Luszczki, J., Halasa, M., Okon, E., Landor, S., Sahlgren, C., Rivero-Muller, A. & Stepulak, A., 13 May 2021, In: International Journal of Molecular Sciences. 22, 10, 5184.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Histone Deacetylase Inhibitor 100%
  • Vorinostat 83%
  • Breast Carcinoma 83%
  • Cells 66%
  • Carcinoma Cell 50%
  5 Citations (Scopus)

  43 Downloads (Pure)
• 2020

  Automated cell tracking using StarDist and TrackMate

  Fazeli, E., Roy, N. H., Follain, G., Laine, R. F., Chamier, L. V., Hänninen, P. E., Eriksson, J. E., Tinevez, J-Y. & Jacquemet, G., 28 Oct 2020, In: f1000research. 9, 1279.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Cells 100%
  • Research Worker 50%
  • T Cell 50%
  • Software 33%
  • Quantitative Imaging 33%
  30 Citations (Scopus)

  74 Downloads (Pure)

• Computational characterization of the dish-in-a-dish, a high yield culture platform for endothelial shear stress studies on the orbital shaker

  Driessen, R., Zhao, F., Hofmann, S., Bouten, C., Sahlgren, C. & Stassen, O., 1 Jun 2020, In: Micromachines. 11, 6, 552.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Shears 100%
  • Orbitals 30%
  • Independent Variables 30%
  • Speed 20%
  • Gene Expression 10%
  12 Citations (Scopus)

  37 Downloads (Pure)

• Heat Shock Factor 2 Protects against Proteotoxicity by Maintaining Cell-Cell Adhesion

  Joutsen, J., Da Silva, A. J., Luoto, J. C., Budzynski, M. A., Nylund, A. S., de Thonel, A., Concordet, J-P., Mezger, V., Sabéran-Djoneidi, D., Henriksson, E. & Sistonen, L., 14 Jan 2020, In: Cell Reports. 30, 2, p. 583-597.e6

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  • Heat Shock Factor 100%
  • Stress 33%
  • Proteotoxicity 33%
  • Cell Adhesion 33%
  • Nested Gene 22%
  29 Citations (Scopus)

• Lateral induction limits the impact of cell connectivity on Notch signaling in arterial walls

  Ristori, T., Stassen, O. M. J. A., Sahlgren, C. M. & Loerakker, S., 2020, In: International Journal for Numerical Methods in Biomedical Engineering. 36, 4, e3323.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Notch 100%
  • Cells 41%
  • Phenotype 20%
  • Dynamics 16%
  • Connectivity 16%
  9 Citations (Scopus)

  23 Downloads (Pure)

• Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies

  Tanaka, N., Kanatani, S., Kaczynska, D., Fukumoto, K., Louhivuori, L., Mizutani, T., Kopper, O., Kronqvist, P., Robertson, S., Lindh, C., Kis, L., Pronk, R., Niwa, N., Matsumoto, K., Oya, M., Miyakawa, A., Falk, A., Hartman, J., Sahlgren, C., Clevers, H., & 1 othersUhlén, P., 2020, In: Nature Biomedical Engineering. 4, 9, p. 875-888 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  • Neoplasm 100%
  • RNA 75%
  • Analysis 75%
  • Cells 75%
  • Malignant Neoplasm 50%
  17 Citations (Scopus)
• 2019

  A Supramolecular Platform for the Introduction of Fc-Fusion Bioactive Proteins on Biomaterial Surfaces

  Putti, M., J. de Jong, S. M., Stassen, O., Sahlgren, C. & W. Dankers, P. Y., 2019, In: ACS Applied Polymer Materials. 1, 8, p. 2044–2054

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
  12 Citations (Scopus)

  11 Downloads (Pure)

• Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress.

  van Engeland, N. C. A., Suarez Rodriguez, F., Rivero-Müller, A., Ristori, T., Duran, C. L., Stassen, O. M. J. A., Antfolk, D., Driessen, R. C. H., Ruohonen, S., Ruohonen, S. T., Nuutinen, S., Savontaus, E., Loerakker, S., Bayless, K. J., Sjöqvist, M., Bouten, C. V. C., Eriksson, J. E. & Sahlgren, C. M., 2019, In: Scientific Reports. 9, p. –

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
  62 Citations (Scopus)

  38 Downloads (Pure)
• 2018

  M1-linked ubiquitination by LUBEL is required for inflammatory responses to oral infection in Drosophila.

  Aalto, A., Mohan, A., Schwintzer, L., Kupka, S., Kietz, C., Walczak, H., Broemer, M. & Meinander, A., 2018, In: Cell Death and Differentiation. p. –

  Research output: Contribution to journal › Article › Scientific › peer-review
  48 Citations (Scopus)