Center of Excellence in Cellular Mechanostasis

Research output

Research output per year 2018 2020 2021 2022 2023

• 19 Article
• 11 Review Article or Literature Review
• 2 Performance
• 1 Chapter

Research output per year

Research output per year

Search results

• 2023

  A multiscale computational model of arterial growth and remodeling including Notch signaling

  van Asten, J. G. M., Latorre, M., Karakaya, C., Baaijens, F. P. T., Sahlgren, C. M., Ristori, T., Humphrey, J. D. & Loerakker, S., 6 Apr 2023, (E-pub ahead of print) In: Biomechanics and modeling in mechanobiology.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Notch 100%
  • Notch Signaling 16%
  • Growth 16%
  • Model 16%
  • Notch Signaling Pathway 16%
  1 Citation (Scopus)

  36 Downloads (Pure)

• Mechanical regulation of the Notch signaling pathway

  Suarez Rodriguez, F., Sanlidag, S. & Sahlgren, C., Dec 2023, In: Current Opinion in Cell Biology. 85, 9 p., 102244.

  Research output: Contribution to journal › Review Article or Literature Review › peer-review

  Open Access

  File

  • Signal Transduction 100%
  • Notch Signaling 100%
  • Regulatory Mechanism 100%
  • Notch Signaling Pathway 100%
  • Notch 100%
  3 Citations (Scopus)

  22 Downloads (Pure)

• Modulating epigenetic modifications for cancer therapy (Review)

  Castro-Muñoz, L. J., Ulloa, E. V., Sahlgren, C., Lizano, M., De La Cruz-Hernández, E. & Contreras-Paredes, A., Mar 2023, In: Oncology Reports. 49, 3, 59.

  Research output: Contribution to journal › Review Article or Literature Review › peer-review

  Open Access

  File

  • Histone Modification 100%
  • Epigenetic Mechanism 100%
  • Epigenetic Modification 100%
  21 Citations (Scopus)

  83 Downloads (Pure)

• Organ‐on‐a‐chip technologies for biomedical research and drug development: A focus on the vasculature

  Soto veliz, D., Lin, K-L. & Sahlgren, C., 1 Feb 2023, In: Smart Medicine. 2, 1

  Research output: Contribution to journal › Review Article or Literature Review › peer-review

  Open Access

  File
  273 Downloads (Pure)
• 2022

  An N-glycan on the C2 domain of JAGGED1 is important for Notch activation

  Meng, Y., Sanlidag, S., Jensen, S. A., Burnap, S. A., Struwe, W. B., Larsen, A. H., Feng, X., Mittal, S., Sansom, M. S. P., Sahlgren, C. & Handford, P. A., 11 Oct 2022, In: Science Signaling. 15, 755, eabo3507.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Polysaccharides 100%
  • Notch 87%
  • C2 Domain 62%
  • Glycosylation 37%
  • N-Terminus 25%
  3 Citations (Scopus)

  23 Downloads (Pure)

• Colonocyte keratin 7 is expressed de novo in inflammatory bowel diseases and associated with pathological changes and drug-resistance

  Polari, L., Tenhami, M., Anttila, S., Helenius, T., Kujari, H., Kallajoki, M., Voutilainen, M. & Toivola, D. M., 23 Dec 2022, In: Scientific Reports. 12, 1, 10 p., 22213.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Keratin 7 100%
  • Inflammatory Bowel Disease 60%
  • Epithelium 20%
  • Biological Marker 20%
  • Colon 20%
  3 Citations (Scopus)

  9 Downloads (Pure)

• Engineered patterns of Notch ligands Jag1 and Dll4 elicit differential spatial control of endothelial sprouting

  Tiemeijer, L., Ristori, T., Stassen, O., Ahlberg, J., de Bijl, J. J. J., Chen, C. S., Bentley, K., Bouten, C. V. C. & Sahlgren, C., 20 May 2022, In: iScience. 25, 5, 104306.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Notch 100%
  • Ligand 25%
  • Sprouting 18%
  • Regulatory Mechanism 18%
  • Angiogenesis 12%
  7 Citations (Scopus)

  52 Downloads (Pure)

• Engineering tissue morphogenesis: taking it up a Notch

  Tiemeijer, L. A., Sanlidag, S., Bouten, C. V. C. & Sahlgren, C., Aug 2022, In: Trends in Biotechnology. 40, 8, p. 945-957 13 p.

  Research output: Contribution to journal › Review Article or Literature Review › peer-review

  Open Access

  File

  • Notch 100%
  • Tissues 50%
  • Cell Fate 33%
  • Morphogenesis 33%
  • Notch Signaling 16%
  7 Citations (Scopus)

  21 Downloads (Pure)

• GIT1 protects against breast cancer growth through negative regulation of Notch

  Zhang, S., Miyakawa, A., Wickström, M., Dyberg, C., Louhivuori, L., Varas-godoy, M., Kemppainen, K., Kanatani, S., Kaczynska, D., Ellström, I. D., Elfman, L., Kronqvist, P., Repo, H., Mikoshiba, K., Sahlgren, C., Johnsen, J. I. & Uhlén, P., 1 Dec 2022, In: Nature Communications. 13, 1, 1537.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Notch 100%
  • GIT1 100%
  • Notch Signaling Pathway 42%
  • Growth 28%
  • Regulatory Mechanism 28%
  8 Citations (Scopus)

  14 Downloads (Pure)

• Reversible and bidirectional signaling of notch ligands

  Vázquez-ulloa, E., Lin, K-L., Lizano, M. & Sahlgren, C., 2022, In: Critical Reviews in Biochemistry and Molecular Biology. 57, 4, p. 377-398

  Research output: Contribution to journal › Review Article or Literature Review › peer-review

  Open Access

  File

  • Notch 100%
  • Ligand 66%
  • Protein Catabolism 16%
  • Eicosanoid Receptor 16%
  • Notch Proteins 16%
  4 Citations (Scopus)

  21 Downloads (Pure)

• Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon

  Stenvall, C-G. A., Tayyab, M., Grönroos, T. J., Ilomäki, M. A., Viiri, K., Ridge, K. M., Polari, L. & Toivola, D. M., Jan 2022, In: Cellular and Molecular Life Sciences. 79, 1, 17 p., 10.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Keratin 8 100%
  • Colon 60%
  • Mouse 40%
  • Epithelial Cell 30%
  • Carcinogenesis 20%
  11 Citations (Scopus)

  26 Downloads (Pure)
• 2021

  Avoiding a replication crisis in deep-learning-based bioimage analysis

  Laine, R. F., Arganda-Carreras, I., Henriques, R. & Jacquemet, G., Oct 2021, In: Nature Methods. 18, p. 1136-1144

  Research output: Contribution to journal › Article › Scientific

  Open Access
  43 Citations (Scopus)

• Drice restrains Diap2-mediated inflammatory signalling and intestinal inflammation

  Kietz, C., Mohan, A. K., Pollari, V., Tuominen, I-E., Ribeiro, P. S., Meier, P. & Meinander, A., 2021, In: Cell Death and Differentiation. 29, 28-39

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access
  7 Citations (Scopus)

• Ex vivo models to decipher the molecular mechanisms of genetic Notch cardiovascular disorders

  Ristori, T., Sjöqvist, M. & Sahlgren, C. M., Mar 2021, In: Tissue Engineering Part C Methods. 27, 3, p. 167-176

  Research output: Contribution to journal › Review Article or Literature Review › peer-review

  Open Access

  File

  • Notch 100%
  • Cardiovascular Disease 37%
  • Signal Transduction 25%
  • Homeostasis 12%
  • Diseases 12%
  3 Citations (Scopus)

  15 Downloads (Pure)

• Imaging in focus: An introduction to denoising bioimages in the era of deep learning

  Laine, R. F., Jacquemet, G. & Krull, A., Nov 2021, In: The International Journal of Biochemistry & Cell Biology. 140

  Research output: Contribution to journal › Review Article or Literature Review › peer-review

  Open Access

  File
  21 Citations (Scopus)

  22 Downloads (Pure)

• Intermediate filament keratins in the exocrine pancreas

  Alam, C., Baghestani, S. & Toivola, D., Dec 2021, The Pancreas: Biology and Physiology. Gorelick, F. & Williams, J. (eds.). Michigan Publishing, p. 72-84 12 p.

  Research output: Chapter in Book/Conference proceeding › Chapter › Scientific › peer-review

• Keratin 7 Is a Constituent of the Keratin Network in Mouse Pancreatic Islets and Is Upregulated in Experimental Diabetes

  Alam, C. M., Baghestani, S., Pajari, A., Omary, M. B. & Toivola, D. M., 21 Jul 2021, In: International Journal of Molecular Sciences. 22, 15, p. 1-16 16 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  • K 18 100%
  • Keratin 57%
  • Cells 57%
  • Experimental Diabetes Mellitus 28%
  • Pancreatic Islet 28%
  6 Citations (Scopus)

• Mechano-regulated cell–cell signaling in the context of cardiovascular tissue engineering

  Karakaya, C., van Asten, J. G. M., Ristori, T., Sahlgren, C. M. & Loerakker, S., 2021, In: Biomechanics and Modeling in Mechanobiology. 21

  Research output: Contribution to journal › Review Article or Literature Review › peer-review

  Open Access

  File

  • Cardiovascular Tissue 100%
  • Cardiovascular Tissue Engineering 75%
  • Tissues 62%
  • Comprehension 37%
  • Engineered Tissue 37%
  6 Citations (Scopus)

  72 Downloads (Pure)

• Notch up a Broken Heart

  Ringbom, A., Sahlgren, C. & Hellsten, L., Aug 2021

  Research output: Non-textual form › Performance › Art in coproduction

• Notch up a Broken Heart - part 2

  Runeberg, R., Sahlgren, C., Österbacka, R. & Hellsten, L., Sept 2021

  Research output: Non-textual form › Performance › Art in coproduction

• PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion

  Landor, S. K. J., Santio, N. M., Eccleshall, W. B., Paramonov, V. M., Gagliani, E. K., Hall, D., Jin, S-B., Dahlström, K. M., Salminen, T. A., Rivero-Müller, A., Lendahl, U., Kovall, R. A., Koskinen, P. J. & Sahlgren, C., 2021, In: Journal of Biological Chemistry. 296, 100593.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Phosphorylation 100%
  • Breast Cancer 100%
  • Notch 75%
  • Phosphotransferase 50%
  • Carcinogenicity 50%
  8 Citations (Scopus)

  94 Downloads (Pure)

• Sensitization of MCF7 Cells with High Notch1 Activity by Cisplatin and Histone Deacetylase Inhibitors Applied Together

  Wawruszak, A., Luszczki, J., Halasa, M., Okon, E., Landor, S., Sahlgren, C., Rivero-Muller, A. & Stepulak, A., 13 May 2021, In: International Journal of Molecular Sciences. 22, 10, 5184.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Histone Deacetylase Inhibitor 100%
  • Vorinostat 83%
  • Breast Carcinoma 83%
  • Cells 66%
  • Carcinoma Cell 50%
  5 Citations (Scopus)

  43 Downloads (Pure)
• 2020

  Automated cell tracking using StarDist and TrackMate

  Fazeli, E., Roy, N. H., Follain, G., Laine, R. F., Chamier, L. V., Hänninen, P. E., Eriksson, J. E., Tinevez, J-Y. & Jacquemet, G., 28 Oct 2020, In: f1000research. 9, 1279.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Cells 100%
  • Research Worker 50%
  • T Cell 50%
  • Software 33%
  • Quantitative Imaging 33%
  30 Citations (Scopus)

  74 Downloads (Pure)

• Computational characterization of the dish-in-a-dish, a high yield culture platform for endothelial shear stress studies on the orbital shaker

  Driessen, R., Zhao, F., Hofmann, S., Bouten, C., Sahlgren, C. & Stassen, O., 1 Jun 2020, In: Micromachines. 11, 6, 552.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Shears 100%
  • Orbitals 30%
  • Independent Variables 30%
  • Speed 20%
  • Gene Expression 10%
  12 Citations (Scopus)

  37 Downloads (Pure)

• From structural resilience to cell specification - Intermediate filaments as regulators of cell fate

  Sjöqvist, M., Antfolk, D., Suarez-Rodriguez, F. & Sahlgren, C., 2020, In: FASEB Journal. 35, 1, e21182.

  Research output: Contribution to journal › Review Article or Literature Review › peer-review

  Open Access

  File

  • Intermediate Filament 100%
  • Stem Cell 50%
  • Signal Transduction 40%
  • Diseases 20%
  • Cell Differentiation 20%
  9 Citations (Scopus)

  61 Downloads (Pure)

• Heat Shock Factor 2 Protects against Proteotoxicity by Maintaining Cell-Cell Adhesion

  Joutsen, J., Da Silva, A. J., Luoto, J. C., Budzynski, M. A., Nylund, A. S., de Thonel, A., Concordet, J-P., Mezger, V., Sabéran-Djoneidi, D., Henriksson, E. & Sistonen, L., 14 Jan 2020, In: Cell Reports. 30, 2, p. 583-597.e6

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  • Heat Shock Factor 100%
  • Stress 33%
  • Proteotoxicity 33%
  • Cell Adhesion 33%
  • Nested Gene 22%
  29 Citations (Scopus)

• Keratin intermediate filaments in the colon: guardians of epithelial homeostasis

  Polari, L., Alam, C. M., Nyström, J. H., Heikkilä, T., Tayyab, M., Baghestani, S. & Toivola, D. M., 2020, In: International Journal of Biochemistry and Cell Biology. 129, 105878.

  Research output: Contribution to journal › Review Article or Literature Review › peer-review

  Open Access

  File

  • Keratin 100%
  • Colon 66%
  • Epithelial Cell 16%
  • Type II Keratin 16%
  • Diagnosis 16%
  35 Citations (Scopus)

  11 Downloads (Pure)

• Lateral induction limits the impact of cell connectivity on Notch signaling in arterial walls

  Ristori, T., Stassen, O. M. J. A., Sahlgren, C. M. & Loerakker, S., 2020, In: International Journal for Numerical Methods in Biomedical Engineering. 36, 4, e3323.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Notch 100%
  • Cells 41%
  • Phenotype 20%
  • Dynamics 16%
  • Connectivity 16%
  9 Citations (Scopus)

  23 Downloads (Pure)

• Notch in mechanotransduction – from molecular mechanosensitivity to tissue mechanostasis

  Stassen, O. M. J. A., Ristori, T. & Sahlgren, C. M., 21 Dec 2020, In: Journal of Cell Science. 133, 24, 14 p., jcs250738.

  Research output: Contribution to journal › Review Article or Literature Review › peer-review

  Open Access

  File

  • Notch 100%
  • Association 75%
  • Mechanics 75%
  • Cell Fate 50%
  • Notch Signaling Pathway 50%
  35 Citations (Scopus)

  75 Downloads (Pure)

• Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies

  Tanaka, N., Kanatani, S., Kaczynska, D., Fukumoto, K., Louhivuori, L., Mizutani, T., Kopper, O., Kronqvist, P., Robertson, S., Lindh, C., Kis, L., Pronk, R., Niwa, N., Matsumoto, K., Oya, M., Miyakawa, A., Falk, A., Hartman, J., Sahlgren, C., Clevers, H., & 1 othersUhlén, P., 2020, In: Nature Biomedical Engineering. 4, 9, p. 875-888 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  • Neoplasm 100%
  • RNA 75%
  • Analysis 75%
  • Cells 75%
  • Malignant Neoplasm 50%
  17 Citations (Scopus)
• 2019

  A Supramolecular Platform for the Introduction of Fc-Fusion Bioactive Proteins on Biomaterial Surfaces

  Putti, M., J. de Jong, S. M., Stassen, O., Sahlgren, C. & W. Dankers, P. Y., 2019, In: ACS Applied Polymer Materials. 1, 8, p. 2044–2054

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
  12 Citations (Scopus)

  11 Downloads (Pure)

• Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress.

  van Engeland, N. C. A., Suarez Rodriguez, F., Rivero-Müller, A., Ristori, T., Duran, C. L., Stassen, O. M. J. A., Antfolk, D., Driessen, R. C. H., Ruohonen, S., Ruohonen, S. T., Nuutinen, S., Savontaus, E., Loerakker, S., Bayless, K. J., Sjöqvist, M., Bouten, C. V. C., Eriksson, J. E. & Sahlgren, C. M., 2019, In: Scientific Reports. 9, p. –

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
  62 Citations (Scopus)

  38 Downloads (Pure)
• 2018

  M1-linked ubiquitination by LUBEL is required for inflammatory responses to oral infection in Drosophila.

  Aalto, A., Mohan, A., Schwintzer, L., Kupka, S., Kietz, C., Walczak, H., Broemer, M. & Meinander, A., 2018, In: Cell Death and Differentiation. p. –

  Research output: Contribution to journal › Article › Scientific › peer-review
  48 Citations (Scopus)