Projects per year
Personal profile
Research interests
My research team at the Structural Bioinformatics Laboratory (SBL) focuses 3D structures of proteins and, particularly, utilizing 3D structures to predict and understand protein function. Our research on the molecular mechanism of infection, inflammation and cancer intertwines crystallography with computational modeling approaches. We aim to find out how proteins interact with other molecules and what is the structural basis for their ligand selectivity. The proteins we are working with are drug targets, off-targets, biomarkers of disease stages, biocatalysts or targets for diagnostics of disease.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Biocenter Finland (HY)(Consortium Biocenter Finland) Person responsible Olli Silvennoinen
Salminen, T. A. (Co-Principal Investigator)
01/01/24 → 31/12/28
Project: Research Council of Finland/Other Research Councils
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Nordic Pharmaceutical Translation and Innovation
Rosenholm, J. (Principal Investigator), Viitala, T. (Co-Principal Investigator), Zhang, H. (Co-Principal Investigator), Salo-Ahen, O. (Co-Principal Investigator), Filppula, A. (Co-Principal Investigator), Wang, X. (Co-Principal Investigator), Bansal, K. (Co-Investigator), Kulkov, I. (Co-Investigator), Ahen, F. (Co-Investigator), Salminen, T. A. (Co-Principal Investigator), Airenne, T. (Co-Investigator), Lehtonen, J. (Co-Investigator), Södergård, B. (Co-Investigator) & Rosenberg, S. (Co-Investigator)
01/01/24 → 31/12/28
Project: Research
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Integrated Structural Biology Infrastructure
Salminen, T. A. (Principal Investigator)
01/01/22 → 31/12/26
Project: Research Council of Finland/Other Research Councils
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Innovativa och selektiva behandlingsmetoder mot borrelios
Salminen, T. A. (Principal Investigator)
Medicinska Understödsföreningen Liv och Hälsa
25/04/24 → 31/12/25
Project: Other
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TuProtCore: Turku Protein Core
Salminen, T. A. (Principal Investigator)
01/01/23 → 31/12/25
Project: Research Council of Finland/Other Research Councils
Publications
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Intracranial Human BT12 Glioblastoma Xenograft is [ 18F]FET PET Negative but 6-[ 18F]Fluoronicotinic Acid PET Positive: Exploring a Novel Approach for Clinical Glioblastoma Imaging.
Ekwe, D., Ayo, A., Zhuang, X., Dillemuth, P., Airenne, T. T., Bakay, E., Lövdahl, P., Kunnas, J., Bai, L., Rajander, J., Salminen, T. A., Rosenholm, J. M., Laakkonen, P. & Li, X.-G., 6 Jul 2026, In: Molecular Pharmaceutics. 23, 7, p. 3843-3854Research output: Contribution to journal › Article › Scientific › peer-review
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Flavodiiron proteins associate pH-dependently with the thylakoid membrane for ferredoxin-1-powered O2 photoreduction
Nikkanen, L., Vakal, S., Hubáček, M., Santana-Sánchez, A., Konert, G., Wang, Y., Boehm, M., Gutekunst, K., Salminen, T. A. & Allahverdiyeva, Y., Jun 2025, In: New Phytologist. 246, 5, p. 2084-2101 18 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile5 Citations (Scopus)40 Downloads (Pure) -
Inorganic carbon levels regulate growth via SigC signaling cascade in cyanobacteria
Kurkela, J., Vuorijoki, L., Vakal, S., Turunen, O., Koskinen, S., Reimann, V., Ray, M., Hess, W. R., Salminen, T. A. & Tyystjärvi, T., Sept 2025, In: New Phytologist. 247, 5, p. 2118-2133Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile1 Citation (Scopus)10 Downloads (Pure) -
Secreted Clever-1 modulates T cell responses and impacts cancer immunotherapy efficacy
Prince, S., Viitala, M., Sjöroos, R., Bendes, Á. Á., Rannikko, J. H., Patten, D. A., di Benedetto, I., Turpin, R., Ylitalo, A., Tyni, L., Figueiredo, C. R., Boström, P., Koskivuo, I., Salminen, T. A., Shetty, S. & Hollmén, M., 23 Jun 2025, In: Theranostics. 15, 15, p. 7501-7527 27 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile7 Citations (Scopus)15 Downloads (Pure) -
Utilizing Monocarboxylate Transporter 1-Mediated Blood-Brain Barrier Penetration for Glioblastoma Positron Emission Tomography Imaging with 6-[18F]Fluoronicotinic Acid
Dillemuth, P., Ayo, A., Airenne, T. T., Lövdahl, P., Bakay, E., Zhuang, X., Liljenback, H., Paunonen, S. T., Kunnas, J., Filppu, P., Rajander, J., Johnson, M. S., Roivainen, A., Salminen, T. A., Rosenholm, J. M., Laakkonen, P. & Li, X.-G., 4 Aug 2025, In: Molecular Pharmaceutics. 22, 8, p. 4819-4830 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile5 Citations (Scopus)11 Downloads (Pure)
Activities
- 5 Hosting an academic visitor
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Pardis Mokhtary
Salminen, T. A. (Host)
1 May 2023 → 30 Sept 2023Activity: Hosting a visitor › Hosting an academic visitor
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Travasso Rui
Salminen, T. A. (Host)
12 Mar 2023 → 18 Mar 2023Activity: Hosting a visitor › Hosting an academic visitor
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Authen Promariya
Salminen, T. A. (Host)
2 Jun 2022 → 3 Jul 2022Activity: Hosting a visitor › Hosting an academic visitor
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Suchanit Ngamkala
Salminen, T. A. (Host)
2 Jun 2022 → 3 Jul 2022Activity: Hosting a visitor › Hosting an academic visitor
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Wuttinun Raksajit
Salminen, T. A. (Host)
2 Jun 2022 → 3 Jul 2022Activity: Hosting a visitor › Hosting an academic visitor