Thomas Nyholm

Publications

Research output per year 2003 2005 2008 2010 2011 2015 2016 2019 2025

• 50 Article
• 2 Review Article or Literature Review
• 1 Commissioned report
• 1 Other contribution

Research output per year

Research output per year

Search results

• 2025

  Research Assessment Exercise 2024 Report: Evaluation of the research environments within the four Strategic Research Profiles of Åbo Akademi University

  Mustaniemi-Laakso, M. (Editor) & Nyholm, T. (Editor), 6 Feb 2025, Åbo: Åbo Akademi. 83 p. (Seminar on Research Evaluation, Åbo, Finland, 07/02/25)

  Research output: Book/Journal/Report › Commissioned report › Professional

  Open Access

  File
  23 Downloads (Pure)
• 2021

  FRET detects lateral interaction between transmembrane domain of EGF receptor and ganglioside GM3 in lipid bilayers

  Nakano, M., Hanashima, S., Hara, T., Kabayama, K., Asahina, Y., Hojo, H., Komura, N., Ando, H., Nyholm, T. K. M., Slotte, J. P. & Murata, M., 1 Aug 2021, In: Biochimica et Biophysica Acta - Biomembranes. 1863, 8, 183623.

  Research output: Contribution to journal › Article › Scientific › peer-review

  • Transmembrane Domain 100%
  • GM3 100%
  • Ganglioside 100%
  • Epidermal Growth Factor Receptor 100%
  • Energy Transfer 100%
  13 Citations (Scopus)

• LAPTM4B controls the sphingolipid and ether lipid signature of small extracellular vesicles

  Dichlberger, A., Zhou, K., Bäck, N., Nyholm, T., Backman, A., Mattjus, P., Ikonen, E. & Blom, T., Feb 2021, In: Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids. 1866, 2, 158855.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Lipid Signature 100%
  • Small Extracellular Vesicles 100%
  • Transmembrane 100%
  • Associated Proteins 100%
  • Transmembrane Protein 100%
  12 Citations (Scopus)

  132 Downloads (Pure)

• VTT-006, an anti-mitotic compound, binds to the Ndc80 complex and suppresses cancer cell growth in vitro

  Laine, L. J., Mäki-Jouppila, J. H. E., Kutvonen, E., Tiikkainen, P., Nyholm, T. K. M., Tien, J. F., Umbreit, N. T., Härmä, V., Kallio, L., Davis, T. N., Asbury, C. L., Poso, A., Gorbsky, G. J. & Kallio, M. J., 2021, In: Oncoscience. 8, p. 134-153 20 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Ndc80 Complex 100%
  • Antimitotic Compounds 100%
  • Antimitotic Agent 100%
  • Kinetochore 100%
  • Spindle Assembly Checkpoint 80%
  17 Downloads (Pure)
• 2020

  Inhibition of Pneumolysin Cytotoxicity by Hydrolysable Tannins

  Maatsola, S., Kurkinen, S., Engström, M. T., Nyholm, T. K. M., Pentikäinen, O., Salminen, J.-P. & Haataja, S., 2020, In: Antibiotics. 9, 12, 930.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  • Hydrolysable Tannins 100%
  • Pneumolysin 100%
  • Tannin Derivative 100%
  • Pentagalloyl Glucose 45%
  • Glucose Pentagallate 45%
  8 Citations (Scopus)

• Sphingomyelin Acyl Chains Influence the Formation of Sphingomyelin- and Cholesterol-Enriched Domains

  Engberg, O., Lin, K.-L., Hautala, V., Slotte, J. P. & Nyholm, T. K. M., 2020, In: Biophysical Journal. 119, 5, p. 913-923 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  • Energy Transfer 100%
  • Liquid-ordered Domain 90%
  • Saturated Phospholipids 90%
  • Transfer Techniques 60%
  • Förster Resonance Energy Transfer 60%
  17 Citations (Scopus)

• The binding mechanism of the virulence factor Streptococcus suis adhesin P subtype to globotetraosylceramide is associated with systemic disease

  Johansson, M. M., Bélurier, E., Papageorgiou, A. C., Sundin, A. P., Rahkila, J., Kallonen, T., Nilsson, U. J., Maatsola, S., Nyholm, T., Käpylä, J., Corander, J., Leino, R., Finne, J., Teneberg, S. & Haataja, S., 2020, In: Journal of Biological Chemistry. 295, 42, p. 14305-14324

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access
  9 Citations (Scopus)
• 2019

  Impact of Acyl Chain Mismatch on the Formation and Properties of Sphingomyelin-Cholesterol Domains

  Nyholm, T., Engberg, O., Hautala, V., Tsuchikawa, H., Lin, K.-L., Murata, M. & Slotte, J. P., 2019, In: Biophysical Journal. 117, 9, p. 1577–1588

  Research output: Contribution to journal › Article › Scientific › peer-review
  18 Citations (Scopus)

• Lateral Segregation of Palmitoyl Ceramide-1-Phosphate in Simple and Complex Bilayers

  Sazzad, M. A., Yasuda, T., Nyholm, T. & Slotte, J. P., 2019, In: Biophysical Journal. 117, 1, p. 36–45

  Research output: Contribution to journal › Article › Scientific › peer-review
  3 Citations (Scopus)

• Lipid-Surrounding Water Molecules Probed by Time-Resolved Emission Spectra of Laurdan

  Watanabe, N., Suga, K., Slotte, J. P., Nyholm, T. & Umakoshi, H., 2019, In: Langmuir. 35, 20, p. 6762–6770

  Research output: Contribution to journal › Article › Scientific › peer-review
  24 Citations (Scopus)

• Membrane Localization and Lipid Interactions of Common Lipid-Conjugated Fluorescence Probes

  Engberg, O., Scheidt, H., Nyholm, T., Slotte, J. P. & Huster, D., 2019, In: Langmuir. 35, 36, p. 11902–11911

  Research output: Contribution to journal › Article › Scientific › peer-review
  8 Citations (Scopus)

• Natural Ceramides and Lysophospholipids Cosegregate in Fluid Phosphatidylcholine Bilayers

  Sazzad, M. A., Möuts, A., Palacios Ortega, J., Lin, K.-L., Nyholm, T. & Slotte, J. P., 2019, In: Biophysical Journal. 116, 6, p. 1105–1114

  Research output: Contribution to journal › Article › Scientific › peer-review
  3 Citations (Scopus)

• Nonlamellar-Phase-Promoting Colipids Enhance Segregation of Palmitoyl Ceramide in Fluid Bilayers

  Möuts, A., Yamamoto, T., Nyholm, T., Murata, M. & Slotte, J. P., 2019, In: Biophysical Journal. 116, 8, p. 1507–1515

  Research output: Contribution to journal › Article › Scientific › peer-review
  1 Citation (Scopus)

• Solvatochromic Modeling of Laurdan for Multiple Polarity Analysis of Dihydrosphingomyelin Bilayer

  Watanabe, N., Goto, Y., Suga, K., Nyholm, T., Slotte, J. P. & Umakoshi, H., 2019, In: Biophysical Journal. 116, 5, p. 874–883

  Research output: Contribution to journal › Article › Scientific › peer-review
  29 Citations (Scopus)

• The Affinity of Sterols for Different Phospholipid Classes and Its Impact on Lateral Segregation

  Nyholm, T., Jaikishan, S., Engberg, O., Hautala, V. & Slotte, J. P., 2019, In: Biophysical Journal. 116, 2, p. 296–307

  Research output: Contribution to journal › Article › Scientific › peer-review
  31 Citations (Scopus)
• 2018

  A Ceramide-Regulated Element in the Late Endosomal Protein LAPTM4B Controls Amino Acid Transporter Interaction

  Zhou, K., Dichlberger, A., Martinez-Seara, H., Nyholm, T., SQ, L., Kim, Y., Vattulainen, I., Ikonen, E. & Blom, T., 2018, In: ACS Central Science. 4, 4, p. 548–558 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
  32 Citations (Scopus)
• 2017

  Bilayer Interactions among Unsaturated Phospholipids, Sterols, and Ceramide

  Slotte, J. P., Yasuda, T., Engberg, O., Sazzad, M. A., Hautala, V., Nyholm, T. & Murata, M., 2017, In: Biophysical Journal. 112, 8, p. 1673–1681

  Research output: Contribution to journal › Article › Scientific › peer-review
  12 Citations (Scopus)
• 2016

  Comparison of Unsaturated Phospholipids Effect on Phase Separation in Cholesterol Free and Cholesterol Containing Bilayers

  Engberg, O., Hautala, V., Kullberg, A., Nyholm, T. & Slotte, J. P., 2016, In: Biophysical Journal. 110, 3, p. 74A–74A 1 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Effect of Lung Surfactant Protein SP-C and SP-C-Promoted Membrane Fragmentation on Cholesterol Dynamics

  Roldan, N., Nyholm, T., Slotte, J. P., Perez-Gil, J. & Garcia-Alvarez, B., 2016, In: Biophysical Journal. 111, 8, p. 1703–1713

  Research output: Contribution to journal › Article › Scientific › peer-review
  30 Citations (Scopus)

• Lipid Interactions and Organization in Complex Bilayer Membranes

  Engberg, O., Yasuda, T., Hautala, V., Matsumori, N., Nyholm, T., Murata, M. & Slotte, J. P., 2016, In: Biophysical Journal. 110, 7, p. 1563–1573

  Research output: Contribution to journal › Article › Scientific › peer-review
  23 Citations (Scopus)

• The Affinity of Cholesterol for Different Phospholipids Affects Lateral Segregation in Bilayers

  Engberg, O., Hautala, V., Yasuda, T., Dehio, H., Murata, M., Slotte, J. P. & Nyholm, T., 2016, In: Biophysical Journal. 111, 3, p. 546–556

  Research output: Contribution to journal › Article › Scientific › peer-review
  57 Citations (Scopus)
• 2015

  Effects of cholesterol and saturated sphingolipids on acyl chain order in 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine bilayers--a comparative study with phase-selective fluorophores

  Engberg, O., Nurmi, H., Nyholm, T. & Slotte, J. P., 2015, In: Langmuir. 31, 14, p. 4255–4263

  Research output: Contribution to journal › Article › Scientific › peer-review
  18 Citations (Scopus)

• Formation of an ordered phase by ceramides and diacylglycerols in a fluid phosphatidylcholine bilayer--Correlation with structure and hydrogen bonding capacity

  Ekman, P., Maula, T., Yamaguchi, S., Yamamoto, T., Nyholm, T., Katsumura, S. & Slotte, J. P., 2015, In: BBA - Biomembranes. 1848, 10, p. 2111–2117

  Research output: Contribution to journal › Article › Scientific › peer-review
  21 Citations (Scopus)

• Formation of Gel-like Nanodomains in Cholesterol-Containing Sphingomyelin or Phosphatidylcholine Binary Membrane As Examined by Fluorescence Lifetimes and 2H NMR Spectra

  Yasuda, T., Matsumori, N., Tsuchikawa, H., Lönnfors, M., Nyholm, T., Slotte, J. P. & Murata, M., 2015, In: Langmuir. 31, p. 13783–13792

  Research output: Contribution to journal › Article › Scientific › peer-review

  21 Citations (Scopus)

• Lipid-protein interplay and lateral organization in biomembranes

  Nyholm, T., 2015, In: Chemistry and Physics of Lipids. 189, p. 48–55

  Research output: Contribution to journal › Article › Scientific › peer-review

  53 Citations (Scopus)
• 2013

  Sterol affinity for phospholipid bilayers is influenced by hydrophobic matching between lipids and transmembrane peptides

  Kristian Ijäs, H., Lönnfors, M. & Nyholm, T., 2013, In: BBA - Biomembranes. 1828, 3, p. 932–937

  Research output: Contribution to journal › Article › Scientific › peer-review
  8 Citations (Scopus)
• 2011

  Construction of a DOPC/PSM/cholesterol phase diagram based on the fluorescence properties of trans-parinaric acid

  Nyholm, T., Lindroos, Westerlund & Slotte, J. P., 2011, In: Langmuir. 27, 13, p. 8339–8350

  Research output: Contribution to journal › Article › Scientific › peer-review
  76 Citations (Scopus)

• Construction of chimeric dual-chain avidin by tandem fusion of the related avidins

  Riihimäki, Kukkurainen, Varjonen, Hörhä, Nyholm, T., Kulomaa & Hytönen, 2011, In: PLoS ONE. 6, 5, p. –

  Research output: Contribution to journal › Article › Scientific › peer-review
  6 Citations (Scopus)

• Lateral sorting in model membranes by cholesterol-mediated hydrophobic matching.

  Kaiser, H.-J., Orłowski, A., Róg, T., Nyholm, T., Chai, W., Feizi, T., Lingwood, D., Vattulainen, I. & Simons, K., 2011, In: Proceedings of the National Academy of Sciences. 108, 40, p. 16628–16633

  Research output: Contribution to journal › Article › Scientific › peer-review
  130 Citations (Scopus)

• Membrane bilayer properties of sphingomyelins with amide-linked 2- or 3-hydroxylated fatty acids

  Ekholm, O., Jaikishan, S., Lönnfors, M., Nyholm, T. & Slotte, J. P., 2011, In: BBA - Biomembranes. 1808, 3, p. 727–732

  Research output: Contribution to journal › Article › Scientific › peer-review
  21 Citations (Scopus)

• N- and O-methylation of sphingomyelin markedly affects its membrane properties and interactions with cholesterol

  Björkbom, A., Róg, T., Kankaanpää, P., Lindroos, D., Kaszuba, K., Kurita, M., Yamaguchi, S., Yamamoto, T., Jaikishan, S., Paavolainen, L., Päivärinne, J., Nyholm, T., Katsumura, S., Vattulainen, I. & Slotte, J. P., 2011, In: BBA - Biomembranes. 1808, 4, p. 1179–1186

  Research output: Contribution to journal › Article › Scientific › peer-review
  42 Citations (Scopus)

• Probing the Lipid-Protein Interface Using Model Transmembrane Peptides with a Covalently Linked Acyl Chain

  Nyholm, T., van Duyl, B., S. Rijkers, D. T., J. Liskamp, R. M. & Antoinette Killian, J., 2011, In: Biophysical Journal. 101, 8, p. 1959–1967

  Research output: Contribution to journal › Article › Scientific › peer-review
  10 Citations (Scopus)

• Sterol Affinity for Glycosphingolipid Containing Bilayer Membranes - effect of Sphingolipid Structure

  Isaksson, J., Lönnfors, M., Grandell, P.-M., Nyholm, T. & Slotte, J. P., 2011

  Research output: Other contribution

• Sterols Have Higher Affinity for Sphingomyelin than for Phosphatidylcholine Bilayers even at Equal Acyl-Chain Order

  Lönnfors, M., F. Doux, J. P., Antoinette Killian, J., Nyholm, T. & Slotte, J. P., 2011, In: Biophysical Journal. 100, 11, p. 2633–2641

  Research output: Contribution to journal › Article › Scientific › peer-review
  85 Citations (Scopus)
• 2010

  Characterization of membrane properties of inositol phosphorylceramide

  Björkbom, Ohvo-Rekilä, H., Kankaanpää, Nyholm, T., Westerlund & Slotte, J. P., 2010, In: BBA - Biochimica et Biophysica Acta. 1798, 3, p. 453–460

  Research output: Contribution to journal › Article › Scientific › peer-review
  16 Citations (Scopus)

• Effect of Sphingomyelin Headgroup Size on Molecular Properties and Interactions with Cholesterol

  Björkbom, A., Róg, T., Kaszuba, K., Kurita, M., Yamaguchi, S., Lönnfors, M., Nyholm, T., Vattulainen, I., Katsumura, S. & Slotte, J. P., 2010, In: Biophysical Journal. 99, 10, p. 3300–3308

  Research output: Contribution to journal › Article › Scientific › peer-review
  71 Citations (Scopus)

• Sterol affinity for bilayer membranes is affected by their ceramide content and the ceramide chain length

  Nyholm, T., Grandell, P.-M., Westerlund, B. & Slotte, J. P., 2010, In: BBA - Biomembranes. 1798, 5, p. 1008–1013

  Research output: Contribution to journal › Article › Scientific › peer-review
  43 Citations (Scopus)

• Transmembrane Peptides Influence the Affinity of Sterols for Phospholipid Bilayers

  Nyström, J., Lönnfors, M. & Nyholm, T., 2010, In: Biophysical Journal. 99, 2, p. 526–533

  Research output: Contribution to journal › Article › Scientific › peer-review
  32 Citations (Scopus)
• 2008

  Cholesterol interactions with fluid-phase phospholipids: effect on the lateral organization on the bilayer

  Halling, Ramstedt, Nyström, J., Slotte, J. P. & Nyholm, T., 2008, In: Biophysical Journal. 95, 8, p. 3861–3871

  Research output: Contribution to journal › Article › Scientific › peer-review
  76 Citations (Scopus)

• Influence of trifluoroethanol on membrane interfacial anchoring interactions of transmembrane alpha-helical peptides

  Özdirekcan, Nyholm, T., Raja, Rijkers, Liskamp & Killian, 2008, In: Biophysical Journal. 94, 4, p. 1315–1325

  Research output: Contribution to journal › Article › Scientific › peer-review
  20 Citations (Scopus)

• Is there a preferential interaction between cholesterol and tryptophan residues in membrane proteins?

  Holt, Almeida, D., Nyholm, T., Loura, Daily, Staffhorst, Rijkers, Koeppe, Prieto & Killian, 2008, In: Biochemistry. 47, 8, p. 2638–2649

  Research output: Contribution to journal › Article › Scientific › peer-review
  25 Citations (Scopus)

• N-palmitoyl-sulfatide participates in lateral domain formation in complex lipid bilayers

  YJE, B., Isaksson, J., Nyholm, T., Slotte, J. P. & Ramstedt, B., 2008, In: BBA - Biomembranes. 1778, 4, p. 954–962

  Research output: Contribution to journal › Article › Scientific › peer-review
  20 Citations (Scopus)
• 2007

  How protein transmembrane segments sense the lipid environment

  Nyholm, T., Özdirekcan & Killian, 2007, In: Biochemistry. 46, 6, p. 1457–1465

  Research output: Contribution to journal › Review Article or Literature Review › peer-review
  134 Citations (Scopus)
• 2006

  Binding properties of HABA-type azo derivatives to avidin and avidin-related protein 4

  Repo, S., [Unknown], T. A. P., Hytönen, V. P., Nyholm, T., Halling, K. K., Huuskonen, J., Pentikäinen, O. T., Rissanen, K., Slotte, J. P., Airenne, T., Salminen, T., .Kulomaa, M. S. & Johnson, M. S., 2006, In: Chemistry and Biology. 13, 10, p. 1029–1039 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
  38 Citations (Scopus)

• Peptides in lipid bilayers: the power of simple models

  Antoinette Killian, J. & Nyholm, T., 2006, In: Current Opinion in Structural Biology. 16, 4, p. 473–479

  Research output: Contribution to journal › Review Article or Literature Review › peer-review
  140 Citations (Scopus)
• 2005

  Avidin related protein 2 shows unique structural and functional features among the avidin protein family

  P Hytönen, V., AE Määttä, J., Kidron, H., K Halling, K., Hörhä, J., Kulomaa, T., Nyholm, T., Johnson, M. S., Salminen, T., S Kulomaa, M. & Airenne, T., 2005, In: BMC Biotechnology. 5, p. – 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
  24 Citations (Scopus)

• Design and construction of highly stable, protease-resistant chimeric avidins

  Hytönen, Määttä, Nyholm, T., Livnah, Eisenberg-Domovich, Hyre, Nordlund, Hörhä, Niskanen, Paldanius, Kulomaa, Porkka, Stayton, Laitinen & Kulomaa, 2005, In: Journal of Biological Chemistry. 280, 11, p. 10228–10233

  Research output: Contribution to journal › Article › Scientific › peer-review
  48 Citations (Scopus)

• Domain Formation and Stability in Complex Lipid Bilayers as Reported by Cholestatrienol

  Isaksson, J., Nyholm, T., Slotte, J. P. & Ramstedt, B., 2005, In: Biophysical Journal. 88, 6, p. 4054–4063

  Research output: Contribution to journal › Article › Scientific › peer-review
  78 Citations (Scopus)

• Dual-affinity avidin molecules

  Hytönen, Nordlund, Hörhä, Nyholm, T., Hyre, Kulomaa, Porkka, Marttila, Stayton, Laitinen & Kulomaa, 2005, In: Proteins. 61, 3, p. 597–607

  Research output: Contribution to journal › Article › Scientific › peer-review
  27 Citations (Scopus)
• 2004

  Chicken avidin-related protein 4/5 shows superior thermal stability when compared with avidin while retaining high affinity to biotin

  Hytönen, Nyholm, T., Pentikäinen, Vaarno, Porkka, Nordlund, Johnson, M. S., Slotte, J. P., Laitinen & Kulomaa, 2004, In: Journal of Biological Chemistry. 279, 10, p. 9337–9343

  Research output: Contribution to journal › Article › Scientific › peer-review
  44 Citations (Scopus)