Projects per year
Personal profile
Research interests
Lipid Transfer Protein Research group, aka Mattjus lab. Glycosphingolipids act as recognition sites on the cell surface, aid to maintain the stability of membranes and connect cells to form tissues. Much remains unknown about the basic aspects of glycosphinglipid synthesis and breakdown and in particular, their intracellular transport. Our research focuses on understanding glycosphingolipid transport inside the cell.
Lab web site
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Projects
- 1 Finished
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The glycolipid transfer protein GLTP - A lipid sorting orchestrator in health and disease
Mattjus, P. (Principal Investigator)
01/09/19 → 31/05/24
Project: Foundation
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Loss of Nrf1 rather than Nrf2 leads to inflammatory accumulation of lipids and reactive oxygen species in human hepatoma cells, which is alleviated by 2-bromopalmitate
Deng, R., Zheng, Z., Hu, S., Wang, M., Feng, J., Mattjus, P., Zhang, Z. & Zhang, Y., Feb 2024, In: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1871, 2, 14 p., 119644.Research output: Contribution to journal › Article › Scientific › peer-review
1 Citation (Scopus)21 Downloads (Pure) -
Glycolipid transfer protein knockout disrupts vesicle trafficking to the plasma membrane
Nurmi, H., Backman, A., Halin, J., Lönnfors, M., Blom, T., Roos-Mattjus, P. & Mattjus, P., Apr 2023, In: Journal of Biological Chemistry. 299, 4, 17 p., 104607.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile4 Citations (Scopus)51 Downloads (Pure) -
LAPTM4B controls the sphingolipid and ether lipid signature of small extracellular vesicles
Dichlberger, A., Zhou, K., Bäck, N., Nyholm, T., Backman, A., Mattjus, P., Ikonen, E. & Blom, T., Feb 2021, In: Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids. 1866, 2, 158855.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile11 Citations (Scopus)117 Downloads (Pure) -
Who moves the sphinx? An overview of intracellular sphingolipid transport
Backman, A. & Mattjus, P., 30 Jul 2021, In: Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids. 1866, 11Research output: Contribution to journal › Review Article or Literature Review › peer-review
Open Access2 Citations (Scopus) -
Ether lipid and sphingolipid expression patterns are estrogen receptor-dependently altered in breast cancer cells
Hahnefeld, L., Gruber, L., Schömel, N., Fischer, C., Mattjus, P., Gurke, R., Beretta, M., Ferreirós, N., Geisslinger, G. & Wegner, M.-S., 2020, In: International Journal of Biochemistry and Cell Biology. 127, p. – 105834.Research output: Contribution to journal › Article › Scientific › peer-review
14 Citations (Scopus)
Prizes
Activities
- 4 Supervision of postgraduate students
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Moving lipids : ceramides, glycosphingolipids and the glycolipid transfer protein
Mattjus, P. (Participant)
2011 → 2016Activity: Supervision, mentoring and other activities › Supervision of postgraduate students
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Glycolipid and ceramide transfer proteins : important determinants for their function
Mattjus, P. (Participant)
2008 → 2013Activity: Supervision, mentoring and other activities › Supervision of postgraduate students
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Properties Regulating the Glycolipid Transfer Protein Activity.
Mattjus, P. (Participant)
2004 → 2009Activity: Supervision, mentoring and other activities › Supervision of postgraduate students
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Lipid and Membrane Binding Properties of Glycolipid Transfer Protein Superfamily Members
Mattjus, P. (Participant)
2003 → 2009Activity: Supervision, mentoring and other activities › Supervision of postgraduate students