Outi Salo-Ahen

Publications

Research output per year 2004 2005 2010 2017 2020 2021 2022 2024

• 44 Article
• 6 Review Article or Literature Review
• 2 Comment/debate
• 1 Commissioned report
• 1 More
  • 1 Other contribution

Research output per year

Research output per year

Search results

• 3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data

  Salo-Ahen, O., Savinainen, Parkkari, Nevalainen, Lahtela-Kakkonen, Gynther, Laitinen, Järvinen & Poso, 2006, In: Journal of Medicinal Chemistry. 49, 2, p. 554–566

  Research output: Contribution to journal › Article › Scientific › peer-review
  22 Citations (Scopus)

• An ecoimmunological approach to study evolutionary and ancient links between coagulation, complement and innate immunity

  Papareddy, P., Kasetty, G., Alyafei, S., Smeds, E., Salo-Ahen, O., Hansson, SR., Egesten, A. & Herwald, H., 2018, In: Virulence. 9, 1, p. 724–737

  Research output: Contribution to journal › Article › Scientific › peer-review
  10 Citations (Scopus)

• Antigenic peptide prediction from E6 and E7 oncoproteins of HPV types 16 and 18 for therapeutic vaccine design using immunoinformatics and MD simulation analysis

  Jabbar, B., Rafique, S., Salo-Ahen, O., Ali, A., Munir, M., Idrees, M., Usman Mirza, M., Vanmeert, M., Zawar Shah, S., Jabbar, I. & Adeel Rana, M., 2018, In: Frontiers in Immunology. 9, p. 1–14

  Research output: Contribution to journal › Article › Scientific › peer-review
  46 Citations (Scopus)

• A rapid method for selecting suitable animal species for studying pathogen interactions with plasma protein ligands in vivo

  Naudin, C., Schumski, A., Salo-Ahen, O., Herwald, H. & Smeds, E., 2017, In: Microbial Biotechnology. 10, 3, p. 657–665

  Research output: Contribution to journal › Article › Scientific › peer-review

• Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes

  Saario, Salo-Ahen, O., Nevalainen, Poso, Laitinen, Järvinen & Niemi, 2005, In: Chemistry and Biology. 12, 6, p. 649–656

  Research output: Contribution to journal › Article › Scientific › peer-review
  148 Citations (Scopus)

• Computational approaches to identifying and characterizing protein binding sites for ligand design

  Henrich, S., Salo-Ahen, O., Huang, B., [Unknown], R. F. F., Cruciani, G. & [Unknown], W. R. C., 2010, In: Journal of Molecular Recognition. 23, 2, p. 209–219

  Research output: Contribution to journal › Article › Scientific › peer-review
  183 Citations (Scopus)

• Design, synthesis, in vitro and in silico characterization of new 2-quinolone-L-alaninate-1,2,3-triazoles as novel antimicrobial agents

  Moussaoui, O., Rajendra, B., Sghyar, R., Ilaš, J., El Hadrami, E. M., Chakroune, S. & Salo-Ahen, O., 4 Mar 2022, In: ChemMedChem. 17, 5, e202100714.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Antimicrobial Agent 100%
  • Antiinfective Agent 100%
  • Quinolone 80%
  • L-Alaninate 60%
  • 1,2,3-triazole 40%
  11 Citations (Scopus)

  70 Downloads (Pure)

• Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding

  Cardinale, Salo-Ahen, O., Guaitoli, Ferrari, Venturelli, Franchini, Battini, Ponterini, Wade & Costi, 2010, In: Protein Engineering, Design and Selection. 23, 2, p. 81–89

  Research output: Contribution to journal › Article › Scientific › peer-review
  7 Citations (Scopus)

• Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth

  Luca, C., Ferrari, S., Santucci, M., Salo-Ahen, O. MH., Carosati, E., Franchini, S., Lauriola, A., Pozzi, C., Trande, M., Gaia, G., Saxena, P., Cannazza, G., Losi, L., Cardinale, D., Venturelli, A., Quotadamo, A., Linciano, P., Lorenzo, T., Moshella, M. G., Guerrini, R., & 19 othersPacifico, S., Luciani, R., Genovese, F., Stefan, H., Silvia, A., Santarem, N., Cordeiro-da-Silva, A., Giovannetti, E., Peters, G., Pinton, P., Rimessi, A., Cruciani, G., Stroud, R., Wade, R. C., Mangani, S., Marverti, G., D'Arca, D., Ponterini, G. & Costi, M. P., 7 Dec 2022, In: eLife. 11, e73862, e73862.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
  4 Downloads (Pure)

• Development of a 3D model for the human cannabinoid CB1 receptor

  Salo-Ahen, O., Lahtela-Kakkonen, Gynther, Järvinen & Poso, 2004, In: Journal of Medicinal Chemistry. 47, 12, p. 3048–3057

  Research output: Contribution to journal › Article › Scientific › peer-review
  77 Citations (Scopus)

• Discovery of HIV entry inhibitors via a hybrid CXCR4 and CCR5 receptor pharmacophore-based virtual screening approach

  Usman Mirza, M., Saadabadi, A., Vanmeert, M., Salo-Ahen, O., Abdullah, I., Claes, S., De Jonghe, S., Schols, D., Ahmad, S. & Froeyen, M., 2020, In: European Journal of Pharmaceutical Sciences. 155, p. – 105537.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • CXCR4 100%
  • CCR5 100%
  • Human Immunodeficiency Virus 75%
  • Receptor 62%
  • Co-Receptor 37%
  21 Citations (Scopus)

  43 Downloads (Pure)

• Disrupters of the Thymidylate Synthase Homodimer Accelerate Its Proteasomal Degradation and Inhibit Cancer Growth

  Luca, C., Ferrari, S., Santucci, M., Salo-Ahen, O., Carosati, E., Franchini, S., Angela, L., Pozzi, C., Marverti, G., Trande, M., Gaia, G., Saxena, P., Cannazza, G., Losi, L., Cardinale, D., Venturelli, A., Quotadamo, A., Linciano, P., Guerrini, R., Pacificio, S., & 17 othersLuciani, R., Genovese, F., Stefan, H., Silvia, A., Santarem, N., Cordeiro-da-Silva, A., Giovannetti, E., Peters, G., Pinton, P., Rimessi, A., Cruciani, G., Stroud, R., Wade, R., Mangani, S., D'Arca, D., Ponterini, G. & Costi, M., 2021, (Submitted) In: ChemRxiv.

  Research output: Contribution to journal › Article › Scientific

• Dynamics of CYP51: Implications for Function and Inhibitor Design

  Xiaofeng, Y., Cojocaru, V., Mustafa, G., Salo-Ahen, O., Lepesheva, G. I. & Wade, R. C., 2015, In: Journal of Molecular Recognition. 28, 2, p. 59–73

  Research output: Contribution to journal › Article › Scientific › peer-review
  29 Citations (Scopus)

• Editorial

  Salo-Ahen, O., 2008, In: Current Topics in Medicinal Chemistry. 8, 3, p. 172–172

  Research output: Contribution to journal › Article › Scientific

• Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system

  Saario, Poso, Juvonen, Järvinen & Salo-Ahen, O., 2006, In: Journal of Medicinal Chemistry. 49, 15, p. 4650–4656

  Research output: Contribution to journal › Article › Scientific › peer-review
  58 Citations (Scopus)

• Functional block copolymer micelles based on poly (jasmine lactone) for improving the loading efficiency of weakly basic drugs

  Ali, A., Bhadane, R., Asl, A. A., Wilén, C-E., Salo-Ahen, O., Rosenholm, J. M. & Bansal, K. K., 21 Sept 2022, In: RSC Advances. 12, p. 26763-26775 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Drug 100%
  • Polymer 100%
  • Micelle 57%
  • Functionalization 57%
  • Lactone 42%
  4 Citations (Scopus)

  13 Downloads (Pure)

• Governing pharmaceutical innovations in Africa: inclusive models for accelerating access to quality medicines

  Ahen, F. & Salo-Ahen, O., 2018, In: Cogent Medicine. 5, 1, p. 1–22

  Research output: Contribution to journal › Article › Scientific › peer-review

  File
  67 Downloads (Pure)

• High-Throughput Dual Screening Method for Ras Activities and Inhibitors

  Kopra, K., van Adrichem, A. J., Salo-Ahen, O., Peltonen, J., Wennerberg, K. & Härmä, H., 2017, In: Analytical Chemistry. 89, 8, p. 4508–4516

  Research output: Contribution to journal › Article › Scientific › peer-review
  12 Citations (Scopus)

• High-Throughput Molecular Dynamics-Based Alchemical Free Energy Calculations for Predicting the Binding Free Energy Change Associated with the Selected Omicron Mutations in the Spike Receptor-Binding Domain of SARS-CoV-2

  Rajendra, B. & Salo-Ahen, O., 1 Nov 2022, In: Biomedicines. 10, 11, 22 p., 2779.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Receptor Binding 100%
  • Mutation 87%
  • Energy 87%
  • Spike 62%
  • Binding Domain 50%
  2 Citations (Scopus)

  55 Downloads (Pure)

• Hops compounds modulatory effects and 6-prenylnaringenin dual mode of action on GABAA receptors

  Benkherouf, A. Y., Logrén, N., Somborac, T., Kortesniemi, M., Soini, S. L., Yang, B., Salo-Ahen, O., Laaksonen, O. & Uusi-Oukari, M., 15 Apr 2020, In: European Journal of Pharmacology. 873, p. – 172962.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Tritium 100%
  • 4 Aminobutyric Acid A Receptor 71%
  • Flumazenil 57%
  • Humulon 57%
  • 4 Aminobutyric Acid 42%
  13 Citations (Scopus)

  56 Downloads (Pure)

• Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase

  Salo-Ahen, O., Tochowicz, A., Pozzi, C., Cardinale, D., Ferrari, S., Boum, Y., Mangani, S., Stroud, RM., Saxena, P., Myllykallio, H., Costi, MP., Ponterini, G. & Wade, RC., 2015, In: Journal of Medicinal Chemistry. 58, 8, p. 3572–3581

  Research output: Contribution to journal › Article › Scientific › peer-review
  22 Citations (Scopus)

• Identification of HPr kinase/phosphorylase inhibitors: novel antimicrobials against resistant Enterococcus faecalis

  Kumar, S., Bhadane, R., Shandilya, S., Salo-Ahen, O. M. H. & Kapila, S., 9 Jul 2022, In: Journal of Computer-Aided Molecular Design. 36, 7, p. 507-520 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Histidine 100%
  • Gram Positive Bacterium 75%
  • Phosphorylase Kinase 75%
  • Phosphorylase 75%
  • Antiinfective Agent 75%
  2 Citations (Scopus)

  26 Downloads (Pure)

• Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor

  Savinainen, Kokkola, Salo-Ahen, O., Poso, Järvinen & Laitinen, 2005, In: British Journal of Pharmacology. 145, 5, p. 636–645

  Research output: Contribution to journal › Article › Scientific › peer-review
  47 Citations (Scopus)

• Inhibition of oncogenic kinases: an in vitro validated computational approach identified potential multi-target anticancer compounds

  Ikram, N., Usman Mirza, M., Vanmeert, M., Froeyen, M., Salo-Ahen, O., Tahir, M., Qazi, A. & Ahmad, S., 2019, In: Biomolecules. 9, 4, p. –

  Research output: Contribution to journal › Article › Scientific › peer-review
  23 Citations (Scopus)

• In Situ Coupled Electrochemical-Goniometry as a Tool to Reveal Conformational Changes of Charged Peptides

  Ghafari, A. M., Domínguez, S. E., Järvinen, V., Gounani, Z., Schmit, A., Sjöqvist, M., Sahlgren, C., Salo-Ahen, O. M. H., Kvarnström, C., Torsi, L. & Österbacka, R., 2021, In: Advanced Materials Interfaces. 9, 4, 2101480.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Peptide 100%
  • Wetting 75%
  • Surface 50%
  • Hydrophilicity 25%
  • Self Assembled Monolayer 25%
  7 Citations (Scopus)

  35 Downloads (Pure)

• Interactions between polymeric nanoparticles and different buffers as investigated by zeta potential measurements and molecular dynamics simulations

  Inam, W., Bhadane, R., Akpolat, R. N., Taiseer, R. A., Filippov, S. K., Salo-Ahen, O. M. H., Rosenholm, J. M. & Zhang, H., 21 Feb 2022, In: VIEW. p. 1-21 21 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Zeta Potential 100%
  • Nanoparticle 44%
  • Gas Fuel Measurement 16%
  • Solution 16%
  • Polymer Nanoparticles 16%
  14 Citations (Scopus)

  219 Downloads (Pure)

• Investigating the Effectiveness of Different Porous Nanoparticles as Drug Carriers for Retaining the Photostability of Pinosylvin Derivative

  Howaili, F., Saadabadi, A., Mäkilä, E., Korotkova, E., Eklund, P. C., Salo-Ahen, O. M. H. & Rosenholm, J. M., 15 Feb 2024, In: Pharmaceutics. 16, 2, 17 p., 276.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Nanocarrier 100%
  • Cytotoxicity 49%
  • Ionization 49%
  • Porous Silicon 49%
  • Ultraviolet Radiation 49%
  38 Downloads (Pure)

• Isolation and functional analysis of phage‐displayed antibody fragments targeting the staphylococcal superantigen‐like proteins

  Alanko, I., Sandberg, R., Brockmann, E-C., de Haas, C. J. C., van Strijp, J. A. G., Lamminmäki, U. & Salo-Ahen, O. M. H., Aug 2023, In: MicrobiologyOpen. 12, 4, 19 p., e1371.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Monospecific Antibody 100%
  • Antibody 100%
  • Immune Evasion 50%
  • Phagocytosis 50%
  • MMP9 50%
  14 Downloads (Pure)

• Market violence through destructive entrepreneurship: Assessing institutional responses to the proliferation of counterfeit traditional and alternative medicines in Ghana

  Ahen, F., Buabeng, K. O. & Salo-Ahen, O. M. H., 23 Feb 2023, In: Heliyon. 9, 3, 16 p., e13881.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Entrepreneurship 100%
  • Alternative Medicine 100%
  • Markets 100%
  • Traditional Medicine 100%
  • Consumers 83%
  2 Citations (Scopus)

  20 Downloads (Pure)

• Molecular Dynamics Prediction Verified by Experimental Evaluation of the Solubility of Different Drugs in Poly(decalactone) for the Fabrication of Polymeric Nanoemulsions

  Pyrhönen, J., Bansal, K. K., Bhadane, R., Wilén, C-E., Salo-Ahen, O. M. H. & Rosenholm, J. M., 29 Nov 2021, In: Advanced NanoBiomed Research. 2, 1, 11 p., 2100072.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Drug 100%
  • Nanoemulsion 85%
  • Polymer 42%
  • Drug Solubility 28%
  • Oil 28%
  9 Citations (Scopus)

  92 Downloads (Pure)

• Molecular Modeling in Drug Design

  Wade, R. C. & Salo-Ahen, O., 2019, In: Molecules. 24, 2, p. –

  Research output: Contribution to journal › Article › Scientific
  12 Citations (Scopus)

• Multivalent Interactions of Human Primary Amine Oxidase with the V and C2₂ Domains of Sialic Acid-Binding Immunoglobulin-Like Lectin-9 Regulate Its Binding and Amine Oxidase Activity

  Elovaara, H., Parkash, V., Fair-Mäkelä, R., Salo-Ahen, O., Guédez, G., Bligt-Lindén, E., Grönholm, J., Jalkanen, S. & Salminen, T., 2016, In: PLoS ONE. 11, 11, p. 1–22

  Research output: Contribution to journal › Article › Scientific › peer-review
  7 Citations (Scopus)

• NBCZone: Universal three-dimensional construction of eleven amino acids near the catalytic nucleophile and base in the superfamily of (chymo)trypsin-like serine fold proteases

  Denesyuk, A. I., Johnson, M. S., Salo-Ahen, O. M. H., Uversky, V. N. & Denessiouk, K., 15 Jun 2020, In: International Journal of Biological Macromolecules. 153, p. 399–411

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Trypsin 100%
  • Serine 100%
  • Position 100%
  • Disulfide Bond 66%
  • Contrast 66%
  5 Citations (Scopus)

  34 Downloads (Pure)

• Novel Amino Acid Derivatives of Quinolines as Potential Antibacterial and Fluorophore Agents

  Moussaoui, O., Rajendra, B., Sghyar, R., El Hadrami, E. M., El Amrani, S., Ben Tama, A., Kandri Rodi, Y., Chakroune, S. & Salo-Ahen, O., 1 Dec 2020, In: Scientia Pharmaceutica. 88, 4, 57.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  • Antiinfective Agent 100%
  • Quinoline Derivative 100%
  • Amino Acid Derivative 66%
  • Ester 66%
  • Glycine 66%
  11 Citations (Scopus)

• Pharmacoinformatics and molecular dynamics simulation studies reveal potential covalent and FDA-approved inhibitors of SARS-CoV-2 main protease 3CLpro

  Alamri, MA., ul Qamar M, T., Mirza, MU., Bhadane, R., Alqahtani, SM., Muneer, I., Froeyen, M. & Salo-Ahen, O., 2020, In: Journal of Biomolecular Structure and Dynamics. p. –

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • SARS Coronavirus 100%
  • Electric Potential 83%
  • Chymotrypsin 83%
  • Coronavirinae 50%
  • Protease Inhibitor 33%
  75 Citations (Scopus)

  49 Downloads (Pure)

• Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase

  Cardinale, Guaitoli, Tondi, Luciani, Henrich, Salo-Ahen, O., Ferrari, Marverti, Guerrieri, Ligabue, Frassineti, Pozzi, Mangani, Fessas, Guerrini, Ponterini, Wade & Costi, 2011, In: Proceedings of the National Academy of Sciences. 108, 34, p. E542–549

  Research output: Contribution to journal › Article › Scientific › peer-review
  73 Citations (Scopus)

• Silica Nanoparticles with Virus-Mimetic Spikes Enable Efficient siRNA Delivery In Vitro and In Vivo

  Fu, J., Han, W., Zhang, X., Sun, Y., Bhadane, R., Wei, B., Li, L., Yu, L., Yang, J., Rosenholm, J. M., Salo-Ahen, O. M. H., Fan, T., Zhang, B., Swelm, W., Al-Ghamdi, A. A., Xia, L., Zhang, H., Qiu, M., Zhang, H. & Wang, X., 21 Dec 2022, In: Research.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Spike 100%
  • Surface Property 33%
  • Length 33%
  • Virus 33%
  • Intracellular Trafficking 33%
  4 Citations (Scopus)

  9 Downloads (Pure)

• Stilbenoid compounds inhibit NF-κB-mediated inflammatory responses in the Drosophila intestine

  Aalto, A. L., Saadabadi, A., Lindholm, F., Kietz, C., Himmelroos, E., Marimuthu, P., Salo-Ahen, O. M. H., Eklund, P. & Meinander, A., 2023, In: Frontiers in Immunology. 14, 12 p., 1253805.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Inflammation 100%
  • Pinosylvin 100%
  • Drosophila 100%
  • Intestine 100%
  • In Vivo 80%
  1 Citation (Scopus)

  6 Downloads (Pure)

• Synthesis and CB1 receptor activities of dimethylheptyl derivatives of 2-arachidonoyl glycerol (2-AG) and 2-arachidonyl glyceryl ether (2-AGE)

  Parkkari, Salo-Ahen, O., Huttunen, Savinainen, Laitinen, Poso, Nevalainen & Järvinen, 2006, In: Bioorganic and Medicinal Chemistry. 14, 8, p. 2850–2858

  Research output: Contribution to journal › Article › Scientific › peer-review
  9 Citations (Scopus)

• The active-inactive transition of human thymidylate synthase: targeted molecular dynamics simulations

  Salo-Ahen, O. & Wade, 2011, In: Proteins. 79, 10, p. 2886–2899

  Research output: Contribution to journal › Article › Scientific › peer-review
  16 Citations (Scopus)

• The discovery of Zika virus NS2B-NS3 inhibitors with antiviral activity via an integrated virtual screening approach

  Mirza, M. U., Alanko, I., Vanmeert, M., Muzzarelli, K. M., Salo-Ahen, O. M. H., Abdullah, I., Kovari, I. A., Claes, S., De Jonghe, S., Schols, D., Schinazi, R. F., Kovari, L. C., Trant, J. F., Ahmad, S. & Froeyen, M., 1 Aug 2022, In: European Journal of Pharmaceutical Sciences. 175, 11 p., 106220.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Zika Virus 100%
  • % Inhibition 33%
  • Proteinase 22%
  • Antiviral Activity 22%
  • Proteinase Inhibition 22%
  7 Citations (Scopus)

  44 Downloads (Pure)

• The functional role of cysteines adjacent to the NRY motif of the human MT1 melatonin receptor

  Kokkola, Salo-Ahen, O., Poso & Laitinen, 2005, In: Journal of Pineal Research. 39, 1, p. 1–11

  Research output: Contribution to journal › Article › Scientific › peer-review
  18 Citations (Scopus)

• Towards peptide vaccines against Zika virus: Immunoinformatics combined with molecular dynamics simulations to predict antigenic epitopes of Zika viral proteins

  Mirza, MU., Rafique, S., Ali, A., Munir, M., Ikram, N., Manan, A., Salo-Ahen, O. & Idrees, M., 2016, In: Scientific Reports. 6, p. 1–17

  Research output: Contribution to journal › Article › Scientific › peer-review
  98 Citations (Scopus)

• Virtual screening of novel CB2 ligands using a comparative model of the human cannabinoid CB2 receptor

  Salo-Ahen, O., Raitio, Savinainen, Nevalainen, Lahtela-Kakkonen, Laitinen, Järvinen & Poso, 2005, In: Journal of Medicinal Chemistry. 48, 23, p. 7166–7171

  Research output: Contribution to journal › Article › Scientific › peer-review
  61 Citations (Scopus)