Personal profile
Research interests
Research focuses on development of methods for analysis and modeling of molecular structures.Expert in scientific IT; compute clusters and computational tools. Provides services and collaborates with Biocenter Finland technology platforms, particularly Biological imaging, Drug Discovery & Chemical Biology, Genome-wide methods, and Structural Biology.
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Collaborations and top research areas from the last five years
Projects
- 1 Active
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Nordic Pharmaceutical Translation and Innovation
Rosenholm, J. (Principal Investigator), Viitala, T. (Co-Principal Investigator), Zhang, H. (Co-Principal Investigator), Salo-Ahen, O. (Co-Principal Investigator), Filppula, A. (Co-Principal Investigator), Wang, X. (Co-Principal Investigator), Bansal, K. (Co-Investigator), Kulkov, I. (Co-Investigator), Ahen, F. (Co-Investigator), Salminen, T. A. (Co-Principal Investigator), Airenne, T. (Co-Investigator), Lehtonen, J. (Co-Investigator), Södergård, B. (Co-Investigator) & Rosenberg, S. (Co-Investigator)
01/01/24 → 31/12/28
Project: Research
Publications
- 15 Article
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Building shape-focused pharmacophore models for effective docking screening
Moyano-Gómez, P., Lehtonen, J., Pentikäinen, O. & Postila, P., Dec 2024, In: Journal of Cheminformatics. 16, 1, p. 97 1.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile2 Citations (Scopus)87 Downloads (Pure) -
Virtual Screening Strategy to Identify Retinoic Acid-Related Orphan Receptor γt Modulators
Jokinen, E., Niemeläinen, M., Kurkinen, S., Lehtonen, J., Lätti, S., Postila, P., Pentikäinen, O. & Niinivehmas, S., 13 Apr 2023, In: Molecules. 28, 8, 20 p., 3420.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile6 Citations (Scopus)54 Downloads (Pure) -
Ligand-Enhanced Negative Images Optimized for Docking Rescoring
Kurkinen, S., Lehtonen, J. V., Pentikäinen, O. & Postila, P., 17 Jul 2022, In: International Journal of Molecular Sciences. 23, 14Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile2 Citations (Scopus)111 Downloads (Pure) -
Optimization of Cavity-Based Negative Images to Boost Docking Enrichment in Virtual Screening
Kurkinen, S. T., Lehtonen, J. V., Pentikäinen, O. T. & Postila, P. A., 28 Feb 2022, In: Journal of Chemical Information and Modeling. 62, 4, p. 1100-1112Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile3 Citations (Scopus)128 Downloads (Pure) -
Optogenetic control of spine-head JNK reveals a role in dendritic spine regression
Hollós, P., John, J. M., Lehtonen, J. & Coffey, E., 2020, In: eNeuro. 7, 1, p. –Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile14 Citations (Scopus)102 Downloads (Pure)
Datasets
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Schema for MariaDB database that has pathogenicity predictions for a gene
Lehtonen, J. V. (Creator), Zenodo, 3 Feb 2025
DOI: 10.5281/zenodo.14793842, https://zenodo.org/records/14793842
Dataset
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Additional file 2 of Building shape-focused pharmacophore models for effective docking screening
Moyano-Gómez, P. (Creator), Lehtonen, J. V. (Creator), Pentikäinen, O. T. (Creator) & Postila, P. A. (Creator), figshare, 11 Sept 2024
DOI: 10.6084/m9.figshare.26996877
Dataset
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Schema for MariaDB database that has pathogenicity predictions for a gene
Lehtonen, J. V. (Creator), Zenodo, 16 Jan 2025
DOI: 10.5281/zenodo.14673444, https://zenodo.org/records/14673444
Dataset
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SynGAPMissenseServer website
Lehtonen, J. V. (Creator), Zenodo, 3 Feb 2025
DOI: 10.5281/zenodo.14793901, https://zenodo.org/records/14793901
Dataset