Eleanor Coffey

Publications

Research output per year 1993 1997 2008 2010 2014 2016 2018 2020 2022 2025

• 58 Article
• 6 Granted patents owned by ÅAU
• 3 Abstract
• 2 Meeting Abstract
• 7 More
  • 2 Review Article or Literature Review
  • 2 Software
  • 1 Book
  • 1 Chapter
  • 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• 2025

  Chondroitin Sulfate-Coated Heteroduplex-Molecular Spherical Nucleic Acids

  Virta, P., Laine, T., Deshpande, P., Tähtinen, V. & ET, C., 2025, In: ChemBioChem. p. e202400908

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  • Chondroitin Sulfate 100%
  • Heteroduplex 100%
  • Tetrasaccharide 42%
  • Tau 42%
  • Light Scattering 28%

• Expanding the Molecular and Clinical Phenotype of Patients With De Novo Variants in KIF5C: A Six Patient Case Series.

  Gracie, S., Deshpande, P., Hollos, P., De, D. K., DM, M., AB, P., JA, S. S., MR, B., LH, S., Brown, K., RJ, F., Larson, A. & Coffey, E., 2025, In: American journal of medical genetics. Part A.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  • KIF5C 100%
  • Missense 100%
  • Motor Performance 100%
  • Gain-of-function mutation 25%
  • Motor Domain 25%
• 2024

  HSV-1 and Cellular miRNAs in CSF-Derived Exosomes as Diagnostically Relevant Biomarkers for Neuroinflammation

  Scheiber, C., Klein, H. C., Schneider, J. M., Schulz, T., Bechter, K., Tumani, H., Kapapa, T., Flinkman, D., Coffey, E., Ross, D., Čistjakovs, M., Nora-Krūkle, Z., Bortolotti, D., Rizzo, R., Murovska, M. & Schneider, E. M., 17 Jul 2024, In: Cells. 13, 14, 1208.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Cerebrospinal Fluid 100%
  • MiR-155-5p 50%
  • Interleukin 8 42%
  • Light Chain 42%
  • Interleukin-8 33%
  2 Citations (Scopus)

  26 Downloads (Pure)

• Jnk1 and downstream signalling hubs regulate anxiety-like behaviours in a zebrafish larvae phenotypic screen

  Hong, Y., Sourander, C., Hackl, B., Patton, J., John, J., Paatero, I. & Coffey, E., 15 May 2024, In: Scientific Reports. 14, 1, 11174.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Phenotypic Screen 100%
  • Zebrafish Larvae 100%
  • Signaling Hub 100%
  • Zebra Fish 100%
  • Anxiolytic Activity 85%
  1 Citation (Scopus)

  3 Downloads (Pure)

• LimROTS Bioconductor software package

  Youssef, A. (Developer), Jeba, A., Lahti, L. & Coffey, E., 19 Dec 2024

  Research output: Non-textual form › Software › Scientific › peer-review
• 2023

  Diagnosis of Parkinson's disease on the basis of decreased overall translation.

  Flinkman, D. (Inventor), Deshpande, P. (Inventor), Hong, Y. (Inventor), James, P. (Inventor), Kaasinen, V. (Inventor), Peltonen, S. (Inventor) & Coffey, E. (Inventor), 23 Oct 2023, IPC No. C120 1/6883, Patent No. EP3555319, 14 Dec 2017, Priority date 11 Dec 2016

  Research output: IPR › Granted patents owned by ÅAU

  • Parkinson's Disease 100%
  • European Union Member State 100%
  • Diagnosis of Parkinson's Disease 100%

• Regulators of proteostasis are translationally repressed in fibroblasts from patients with sporadic and LRRK2-G2019S Parkinson's disease

  Flinkman, D., Hong, Y., Gnjatovic, J., Deshpande, P., Ortutay, Z., Peltonen, S., Kaasinen, V., James, P. & Coffey, E., 6 Feb 2023, In: NPJ Parkinson's disease. 9, 1, p. 20

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Proteostasis 100%
  • Protein Biosynthesis 20%
  • YTHDF3 16%
  • Sporadic Patient 16%
  • LRKK2 16%
  7 Citations (Scopus)

  98 Downloads (Pure)
• 2022

  Long-term osteogenic differentiation of human bone marrow stromal cells in simulated microgravity: novel proteins sighted

  Montagna, G., Pani, G., Flinkman, D., Cristofaro, F., Pascucci, B., Massimino, L., Lamparelli, L. A., Fassina, L., James, P., Coffey, E., Rea, G., Visai, L. & Rizzo, A. M., 1 Oct 2022, In: Cellular and Molecular Life Sciences. 79, 10, 536.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Novel Protein 100%
  • Simulated Microgravity 100%
  • Osteogenic Differentiation 100%
  • Nanocrystalline Material 100%
  • Morphology 100%
  8 Citations (Scopus)

  31 Downloads (Pure)

• Loss of Rab8a in B cells leads to increased antibody responses and class-switch recombination.

  Hernández-Pérez, S., Sarapulov, A. V., Balci, M. Ö., Coffey, E., Harada, A. & Mattila, P. K., 2022, In: bioRxiv.

  Research output: Contribution to journal › Article › Scientific

  • Rab8a 100%
  • Antibody Class 100%
  • Class Switch Recombination 100%
  • BioRxiv 100%
  • Immunoglobulin Class Switching 100%

• PhosPiR: an automated phosphoproteomic pipeline in R

  Hong, Y., Flinkman, D., Suomi, T., Pietilä, S., James, P., Coffey, E. & Elo, L. L., Jan 2022, In: Briefings in Bioinformatics. 23, 1

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Phosphoproteomics 100%
  • Mass Spectroscopy 100%
  • Data Mining 100%
  • Data Transmission 100%
  • Proteome-wide 66%
  7 Citations (Scopus)

  54 Downloads (Pure)

• PhosPir and automated pipeline in R

  Hong, Y. (Developer), Elo, L. L., Flinkman, D., James, P. & Coffey, E., 2022

  Research output: Non-textual form › Software › Scientific › peer-review

• 全体的な翻訳の減少に基づくパーキンソン病の診断Applicant オーボ　アカデミー　ユニヴァーシティ(Diagnosis of PArkinsons disease on the basis of decreased overall translation)

  Coffey, E. (Inventor), Flinkman, D. (Inventor), Deshpande, P. (Inventor), James, P. (Inventor), Hong, Y. (Inventor), Laurén, T.L.-P. (Inventor), Kaasinen, V. (Inventor) & Peltonen, S. (Inventor), 22 Mar 2022, IPC No. C120 1/6883, Patent No. JP2020504815, Priority date 11 Dec 2016

  Research output: IPR › Granted patents owned by ÅAU
• 2021

  SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling

  Salomaa, S. I., Miihkinen, M., Kremneva, E., Paatero, I., Lilja, J., Jacquemet, G., Vuorio, J., Antenucci, L., Kogan, K., Hassani Nia, F., Hollos, P., Isomursu, A., Vattulainen, I., Coffey, E. T., Kreienkamp, H.-J., Lappalainen, P. & Ivaska, J., 22 Nov 2021, In: Current Biology. 31, 22, p. 4956-4970.e9

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  • Rap1 100%
  • SHANK3 100%
  • Actin Binding 100%
  • Shank 50%
  • ProSAP 50%
  20 Citations (Scopus)
• 2020

  Impact of JNK and Its Substrates on Dendritic Spine Morphology

  Komulainen, E., Varidaki, A., Kulesskaya, N., Mohammad, H., Sourander, C., Rauvala, H. & Coffey, E. T., 14 Feb 2020, In: Cells. 9, 2

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  • JNK1 100%
  • Dendritic Spine Morphology 100%
  • Mushroom Spines 50%
  • Thin Spines 50%
  • Spine Morphology 33%
  16 Citations (Scopus)

• Optogenetic control of spine-head JNK reveals a role in dendritic spine regression

  Hollós, P., John, J. M., Lehtonen, J. & Coffey, E., 2020, In: eNeuro. 7, 1, p. –

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • JNK Inhibitor 100%
  • Optogenetic Control 100%
  • Spine Head 100%
  • Dendritic Spines 100%
  • Corticosterone 100%
  12 Citations (Scopus)

  32 Downloads (Pure)

• PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteins

  Santio, N. M., Vainio, V., Hoikkala, T., Mung, K. L., Lång, M., Vahakoski, R., Zdrojewska, J., Coffey, E. T., Kremneva, E., Rainio, E.-M. & Koskinen, P. J., 8 Aug 2020, In: Cell Communication and Signaling. 18, 1

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  • Cancer Cell Motility 100%
  • PIM-1 100%
  • Actin Capping Protein 100%
  • Capping Protein 100%
  • Actin Capping 100%
  16 Citations (Scopus)

• Protein synthesis is suppressed in sporadic and familial Parkinson's disease by LRRK2

  Deshpande, P., Flinkman, D., Hong, Y., Goltseva, E., Siino, V., Sun, L., Peltonen, S., Elo, L. L., Kaasinen, V., James, P. & Coffey, E. T., Nov 2020, In: FASEB Journal. 34, 11, p. 14217-14233 17 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  • Protein Synthesis 100%
  • Idiopathic Parkinson's Disease 100%
  • Leucine-rich Repeat Kinase 2 (LRRK2) 100%
  • Familial Parkinson's Disease 100%
  • Rotenone 66%
  19 Citations (Scopus)
• 2019

  Diagnosis of Parkinson's disease on the basis of decreased overal ltranslation

  Coffey, E. (Inventor), 26 Dec 2019, IPC No. C120 1/6883, Patent No. 16469337, 11 Dec 2016

  Research output: IPR › Granted patents owned by ÅAU

• L-alpha-amino adipic acid provokes depression-like behaviour and a stress related increase in dendritic spine density in the pre-limbic cortex and hippocampus in rodents

  David, J., Gormley, S., McIntosh, A., Kebede, V., Thuery, G., Varidaki, A., Coffey, E. & Harkin, A., 2019, In: Behavioural Brain Research. 362, p. 90–102

  Research output: Contribution to journal › Article › Scientific › peer-review
  20 Citations (Scopus)
• 2018

  A novel method for minimal non-invasive diagnosis of Parkinson’s Disease

  Coffey, E. (Inventor), Hong, Y. (Inventor), Flinkman, D. (Inventor), James, P. (Inventor), Deshpande, P. (Inventor), Kaasinen, V. (Inventor) & Peltonen, S. (Inventor), 21 Jun 2018, Patent No. WO/2018/109277

  Research output: IPR › Granted patents owned by ÅAU

• Diagnosis of Parkinson's disease on the basis of decreased overall translation

  Coffey, E. (Inventor), James, P. (Inventor), Flinkman, D. (Inventor), Deshpande, P. (Inventor), Hong, Y. (Inventor), Kaasinen, V. (Inventor) & Laurén, T.L.-P. (Inventor), 21 Jun 2018, Priority date 14 Dec 2016, Priority No. 20165967

  Research output: IPR › Granted patents owned by ÅAU

• Diagnosis of Parkinson's disease on the basis of overall decreased translation

  Coffey, E. (Inventor), Deshpande, P. (Inventor), Flinkman, D. (Inventor), James, P. (Inventor), Laurén, T.L.-P. (Inventor), Kaasinen, V. (Inventor) & Peltonen, S. (Inventor), 21 Jun 2018, IPC No. 120 1/6883, Patent No. WO/2018/109277, 11 Dec 2016

  Research output: IPR › Granted patents owned by ÅAU

• JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche

  Mohammad, H., Marchisella, F., Ortega-Martinez, S., Hollos, P., Eerola, K., Komulainen, E., Kulesskaya, N., Freemantle, E., Fagerholm, V., Savontous, E., Rauvala, H., Peterson, B. D., van Praag, H. & Coffey, E. T., Feb 2018, In: Molecular Psychiatry. 23, 2, p. 487

  Research output: Contribution to journal › Article › Scientific › peer-review

  • Autonomous Control 100%
  • Neurogenic Niche 100%
  • Adult Hippocampal Neurogenesis 100%
  • Neurogenesis 100%
  • 2,5-Dimethoxy-4-iodoamphetamine 100%
  1 Citation (Scopus)

• JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche

  Mohammad, H., Marchisella, F., Ortega Martinez, S., Hollós, P., Eerola, K., Komulainen, E., Kulesskaya, N., Freemantle, E., Fagerholm, V., Savontaus, E., Rauvala, H., Peterson, B., van Praag, H. & Coffey, E., 2018, In: Molecular Psychiatry. 23, 2, p. 362–374

  Research output: Contribution to journal › Article › Scientific › peer-review
  51 Citations (Scopus)

• JNK Regulation of Depression and Anxiety.

  Hollós, P., Marchisella, F. & Coffey, E., 2018, In: Brain Plasticity. 3, 2, p. 145–155

  Research output: Contribution to journal › Review Article or Literature Review › peer-review

• Repositioning Microtubule Stabilizing Drugs for Brain Disorders.

  Varidaki, A., Hong, Y. & Coffey, E., Aug 2018, In: Frontiers in Cellular Neuroscience. 12, p. –

  Research output: Contribution to journal › Article › Scientific › peer-review
  54 Citations (Scopus)

• Synthesis of Azide-Modified Chondroitin Sulfate Precursors: Substrates for "Click"- Conjugation with Fluorescent Labels and Oligonucleotides.

  Jadhav, S., Gulumkar, V., Deshpande, P., Coffey, E., Lönnberg, H. & Virta, P., 2018, In: Bioconjugate Chemistry. 29, 7, p. 2382–2393

  Research output: Contribution to journal › Article › Scientific › peer-review
  12 Citations (Scopus)
• 2016

  JNK1 regulates adult hippocampal neurogenesis and controls anxiety and depressive behaviour.

  Coffey, E., 2016.

  Research output: Contribution to conference › Abstract › Scientific

• KIF5C S176 Phosphorylation Regulates Microtubule Binding and Transport Efficiency in Mammalian Neurons

  Padzik, A., Deshpande, P., Hollós, P., Franker, M., Rannikko, E. H., Cai, D., Prus, P., Mågård, M., Westerlund, N., Verhey, K. J., James, P., Hoogenraad, C. C. & Coffey, E., 2016, In: Frontiers in Cellular Neuroscience. 10, p. 1–15

  Research output: Contribution to journal › Article › Scientific › peer-review
  24 Citations (Scopus)

• Microtubule and microtubule associated protein anomalies in psychiatric disease

  Marchisella, F., Coffey, E. & Hollós, P., 2016, In: Cytoskeleton. 73, 10, p. 596–611

  Research output: Contribution to journal › Review Article or Literature Review › peer-review
  86 Citations (Scopus)

• Molecular Mechanisms of Depression

  Varidaki, A., Mohammad, H. & Coffey, E., 2016, Systems Neuroscience in Depression. Frodl, T. (ed.). Academic Press, p. 143-178

  Research output: Chapter in Book/Conference proceeding › Chapter › Scientific › peer-review
  6 Citations (Scopus)

• Systems Neuroscience in Depression

  Coffey, E., 2016, (Elsevier)

  Research output: Book/Journal/Report › Book › Scientific › peer-review
• 2014

  CANDLES, an assay for monitoring GPCR induced cAMP generation in cell cultures.

  Trehan, A., Rotgers, E., Coffey, E., Huhtaniemi, I. & Rivero-Müller, A., Nov 2014, In: Cell communication and signaling : CCS.

  Research output: Contribution to journal › Article › Scientific › peer-review
  20 Citations (Scopus)

• JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size, and influences fine motor coordination.

  Komulainen, E., Zdrojewska, J., Freemantle, E., Mohammad, H., Kulesskaya, N., Deshpande, P., Marchisella, F., Mysore, R., Hollos, P., Michelsen, K., Mågard, M. & Coffey, E., Sept 2014, In: Frontiers in Cellular Neuroscience.

  Research output: Contribution to journal › Article › Scientific › peer-review
  28 Citations (Scopus)

• Nuclear and cytosolic JNK signalling in neurons.

  Coffey, E., May 2014, In: Nature reviews. Neuroscience.

  Research output: Contribution to journal › Article › Scientific › peer-review
  258 Citations (Scopus)

• The impact of JNK on neuronal migration.

  Zdrojewska, J. & Coffey, E., Jan 2014, In: Advances in Experimental Medicine and Biology.

  Research output: Contribution to journal › Article › Scientific › peer-review
  7 Citations (Scopus)
• 2013

  Translocation of Vibrio parahaemolyticus across an in vitro M cell model.

  Finn, R., Ahmad, T., Coffey, E., Brayden, D., Baird, A. & Boyd, A., Nov 2013, In: FEMS Microbiology Letters.

  Research output: Contribution to journal › Article › Scientific › peer-review
  10 Citations (Scopus)
• 2012

  c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells.

  Björkblom, B., Padzik, A., Mohammad, H., Westerlund, N., Komulainen, E., Hollos, P., Parviainen, L., Papageorgiou, A., Iljin, K., Kallioniemi, O., Kallajoki, M. & Coffey, E., Jul 2012, In: Molecular and Cellular Biology.

  Research output: Contribution to journal › Article › Scientific › peer-review
  70 Citations (Scopus)

• The prognostic value of MARCKS-like 1 in lymph node-negative breast cancer.

  Jonsdottir, K., Zhang, H., Jhagroe, D., Skaland, I., Slewa, A., Björkblom, B., Coffey, E., Gudlaugsson, E., Smaaland, R., Janssen, E. & Baak, J., Jul 2012, In: Breast Cancer Research and Treatment.

  Research output: Contribution to journal › Article › Scientific › peer-review
  19 Citations (Scopus)
• 2011

  Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration.

  Mai, A., Veltel, S., Pellinen, T., Padzik, A., Coffey, E., Marjomäki, V. & Ivaska, J., Jul 2011, In: The Journal of cell biology.

  Research output: Contribution to journal › Article › Scientific › peer-review
  78 Citations (Scopus)

• Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate.

  Westerlund, N., Zdrojewska, J., Padzik, A., Komulainen, E., Björkblom, B., Rannikko, E., Tararuk, T., Garcia-Frigola, C., Sandholm, J., Nguyen, L., Kallunki, T. & Coffey, E., Feb 2011, In: Nature Neuroscience.

  Research output: Contribution to journal › Article › Scientific › peer-review
  97 Citations (Scopus)
• 2010

  Activating transcription factor 3 is a positive regulator of human IFNG gene expression.

  Filén, S., Ylikoski, E., Tripathi, S., West, A., Björkman, M., Nyström, J., Ahlfors, H., Coffey, E., Rao, K., Rasool, O. & Lahesmaa, R., Mar 2010, In: Journal of immunology (Baltimore, Md. : 1950).

  Research output: Contribution to journal › Article › Scientific › peer-review
  36 Citations (Scopus)

• AMPAR signaling mediating GABA(A)R delta subunit up-regulation in cultured mouse cerebellar granule cells.

  Uusi-Oukari, M., Kontturi, L., Coffey, E. & Kallinen, S., May 2010, In: Neurochemistry International.

  Research output: Contribution to journal › Article › Scientific › peer-review
  4 Citations (Scopus)

• Microtubule stabilization by bone morphogenetic protein receptor-mediated scaffolding of c-Jun N-terminal kinase promotes dendrite formation.

  Podkowa, M., Zhao, X., Chow, C., Coffey, E., Davis, R. & Attisano, L., Feb 2010, In: Molecular and Cellular Biology.

  Research output: Contribution to journal › Article › Scientific › peer-review
  61 Citations (Scopus)

• The Vibrio parahaemolyticus Type III Secretion Systems manipulate host cell MAPK for critical steps in pathogenesis.

  Matlawska-Wasowska, K., Finn, R., Mustel, A., O'Byrne, C., Baird, A., Coffey, E. & Boyd, A., Dec 2010, In: BMC Microbiology.

  Research output: Contribution to journal › Article › Scientific › peer-review
  48 Citations (Scopus)
• 2009

  Concurrent protective and destructive signaling of JNK2 in neuroblastoma cells.

  Waetzig, V., Wacker, U., Haeusgen, W., Björkblom, B., Courtney, M., Coffey, E. & Herdegen, T., Jun 2009, In: Cellular Signalling.

  Research output: Contribution to journal › Article › Scientific › peer-review
  12 Citations (Scopus)

• Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.

  Morfini, G., You, Y., Pollema, S., Kaminska, A., Liu, K., Yoshioka, K., Björkblom, B., Coffey, E., Bagnato, C., Han, D., Huang, C., Banker, G., Pigino, G. & Brady, S., Jun 2009, In: Nature Neuroscience.

  Research output: Contribution to journal › Article › Scientific › peer-review
  225 Citations (Scopus)

• SCG10/STATHMIN-2 phosphorylation determines the rate of neuronal migration.

  Coffey, E. & Zdrojewska, J., 23 Aug 2009.

  Research output: Contribution to conference › Abstract › Scientific › peer-review
• 2008

  All JNKs can kill, but nuclear localization is critical for neuronal death.

  Björkblom, B., Vainio, J., Hongisto, V., Herdegen, T., Courtney, M. & Coffey, E., May 2008, In: The Journal of biological chemistry.

  Research output: Contribution to journal › Article › Scientific › peer-review
  78 Citations (Scopus)

• IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration.

  Johansen, L., Naumanen, T., Knudsen, A., Westerlund, N., Gromova, I., Junttila, M., Nielsen, C., Bøttzauw, T., Tolkovsky, A., Westermarck, J., Coffey, E., Jäättelä, M. & Kallunki, T., Feb 2008, In: Journal of Cell Science.

  Research output: Contribution to journal › Article › Scientific › peer-review
  90 Citations (Scopus)