Doctoral Network in Molecular Biosciences

Publications

Research output per year 2014 2016 2017 2018 2019 2024

• 672 Citations
• 14 h-index
• 26 Article
• 3 Review Article or Literature Review
• 2 Doctoral Thesis

Research output per year

Research output per year

Search results

• 2024

  Defining a timeline of colon pathologies after keratin 8 loss: Rapid crypt elongation and diarrhea are followed by epithelial erosion and cell exfoliation

  Ilomäki, M., Polari, L., Stenvall, C-G. A., Tayyab, M., Kähärä, K., Ridge, K. M. & Toivola, D. M., 1 Jan 2024, In: AJP - Gastrointestinal and Liver Physiology. 326, 1, p. G67-G77 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Keratin 8 100%
  • Colon 100%
  • Erosion 100%
  • Gene Expression 40%
  • Mouse 40%
  28 Downloads (Pure)
• 2023

  Environmental stiffness restores mechanical homeostasis in vimentin-depleted cells

  Grolleman, J., van Engeland, N. C. A., Raza, M., Azimi, S., Conte, V., Sahlgren, C. M. & Bouten, C. V. C., 26 Oct 2023, In: Scientific Reports. 13, 12 p., 18374.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Stiffness 100%
  • Vimentin 100%
  • Morphology 66%
  • Compensation Mechanism 50%
  • Stiffness Matrix 50%
  15 Downloads (Pure)

• Photocross-Linkable and Shape-Memory Biomaterial Hydrogel Based on Methacrylated Cellulose Nanofibres

  Brusentsev, Y., Yang, P., King, A. W. T., Cheng, F., Cortes Ruiz, M. F., Eriksson, J. E., Kilpeläinen, I., Willför, S., Xu, C., Wågberg, L. & Wang, X., 14 Aug 2023, In: Biomacromolecules. 24, 8, p. 3835-3845 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Hydrogel 100%
  • Biomaterial 100%
  • Shape Memory 100%
  • Cellulose 100%
  • Nanofibers 100%
  1 Citation (Scopus)

  19 Downloads (Pure)
• 2022

  An N-glycan on the C2 domain of JAGGED1 is important for Notch activation

  Meng, Y., Sanlidag, S., Jensen, S. A., Burnap, S. A., Struwe, W. B., Larsen, A. H., Feng, X., Mittal, S., Sansom, M. S. P., Sahlgren, C. & Handford, P. A., 11 Oct 2022, In: Science Signaling. 15, 755, eabo3507.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Polysaccharides 100%
  • Notch 87%
  • C2 Domain 62%
  • Glycosylation 37%
  • N-Terminus 25%
  3 Citations (Scopus)

  23 Downloads (Pure)
• 2020

  Impact of JNK and Its Substrates on Dendritic Spine Morphology

  Komulainen, E., Varidaki, A., Kulesskaya, N., Mohammad, H., Sourander, C., Rauvala, H. & Coffey, E. T., 14 Feb 2020, In: Cells. 9, 2

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  • Dendritic Spine 100%
  • Phosphorylation 66%
  • Synapsin I 33%
  • Regulator Protein 33%
  • MARCKS Protein 33%
  11 Citations (Scopus)

• Nanoparticles carrying fingolimod and methotrexate enables targeted induction of apoptosis and immobilization of invasive thyroid cancer

  Niemelä, E., Desai, D., Niemi, R., Doroszko, M., Özliseli, E., Kemppainen, K., Rahman, N., Sahlgren, C., Törnquist, K., Eriksson, J. & Rosenholm, J., Mar 2020, In: European Journal of Pharmaceutics and Biopharmaceutics. 148, p. 1–9

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

  • Malignant Neoplasm 100%
  • Drug 80%
  • Mesoporous Silica Nanoparticle 80%
  • Fingolimod 80%
  • Thyroid Cancer 80%
  26 Citations (Scopus)

  52 Downloads (Pure)
• 2019

  Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis

  Baker-Williams, A. J., Hashmi, F., Budzynski, M., Woodford, M. R., Gleicher, S., Himanen, S., Makedon, A. M., Friedman, D., Cortes, S., Namek, S., Stetler-Stevenson, W. G., Bratslavsky, G., Bah, A., Mollapour, M., Sistonen, L. & Bourboulia, D., 2019, In: Cell Reports. 28, 7, p. 1894–1906

  Research output: Contribution to journal › Article › Scientific › peer-review
  48 Citations (Scopus)

• Quantitative bioimage analytics enables measurement of targeted cellular stress response induced by celastrol-loaded nanoparticles

  Niemelä, E., Desai, D., Lundsten, E., Rosenholm, J., Kankaanpää, P. & Eriksson, J., 2019, In: Cell Stress and Chaperones. 24, 4, p. 735–748

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
  4 Citations (Scopus)

  51 Downloads (Pure)
• 2018

  Enabling flexible dosing in orodispersible paediatric formulations by means of solvent casting and thermal inkjet printing

  Öblom, H., Pollmann, I., Desai, D., Özliseli, E., Rosenholm, J., Preis, M., Salunke, S. (ed.) & Tuleu, C. (ed.), 2018, In: International Journal of Pharmaceutics. 536, p. 495–496

  Research output: Contribution to journal › Article › Scientific

  • Drug 100%
  • Solvent 100%
  • Dosage Forms 28%
  • Ink 14%

• JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche

  Mohammad, H., Marchisella, F., Ortega Martinez, S., Hollós, P., Eerola, K., Komulainen, E., Kulesskaya, N., Freemantle, E., Fagerholm, V., Savontaus, E., Rauvala, H., Peterson, BD., van Praag, H. & Coffey, E., 2018, In: Molecular Psychiatry. 23, 2, p. 362–374

  Research output: Contribution to journal › Article › Scientific › peer-review
  48 Citations (Scopus)

• Photo-thermal and cytotoxic properties of inkjet-printed copper sulfide films on biocompatible latex coated substrates

  Sarfraz, J., Borzenkov, M., Niemelä, E., Weinberger, C., Törngren, B., Rosqvist, E., Collini, M., Pallavicini, P., Eriksson, J., Peltonen, J., Ihalainen, P. & Chirico, G., 2018, In: Applied Surface Science. 435, p. 1087–1095

  Research output: Contribution to journal › Article › Scientific › peer-review
  13 Citations (Scopus)

• Repositioning Microtubule Stabilizing Drugs for Brain Disorders.

  Varidaki, A., Hong, Y. & Coffey, ET., Aug 2018, In: Frontiers in Cellular Neuroscience. 12, p. –

  Research output: Contribution to journal › Article › Scientific › peer-review
  50 Citations (Scopus)
• 2017

  Analyses in zebrafish embryos reveal that nanotoxicity profiles are dependent on surface-functionalization controlled penetrance of biological membranes

  Paatero, I., Casals Mercadal, E., Niemi, R., Özliseli, E., Rosenholm, J. & Sahlgren, C., 2017, In: Scientific Reports. 7, p. – 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
  42 Citations (Scopus)

• Chaperone co-inducer BGP-15 inhibits histone deacetylases and enhances the heat shock response through increased chromatin accessibility

  Budzyński, M. A., Crul, T., Himanen, S. V., Toth, N., Otvos, F., Sistonen, L. & Vigh, L., Sept 2017, In: Cell Stress and Chaperones. 22, 5, p. 717-728 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  • Heat Shock Response 100%
  • Histone 66%
  • Protein Homeostasis 50%
  • Chromatin 50%
  • Inducer 33%

• Internal epithelia in Drosophila display rudimentary competence to form cytoplasmic networks of transgenic human vimentin

  Gullmets, J., Torvaldson, E., Lindqvist, J., Imanishi, S., Taimen, P., Meinander, A. & Eriksson, J., 2017, In: FASEB Journal. 31, 12, p. 5332–5341

  Research output: Contribution to journal › Article › Scientific › peer-review
  2 Citations (Scopus)

• Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway

  Lähdeniemi, I., Misiorek, J., Antila, C., Landor, S., Stenvall, C-G., Fortelius, L., Bergström, LK., Sahlgren, C. & Toivola, D., 2017, In: Cell Death and Differentiation. 24, 6, p. 984–996

  Research output: Contribution to journal › Article › Scientific › peer-review
  37 Citations (Scopus)

• Keratins regulate β-cell mitochondrial morphology, motility, and homeostasis

  Silvander, J., Kvarnström, SM., Kumari-Ilieva, A., Shrestha, A., Alam, CM. & Toivola, D., 2017, In: FASEB Journal. 31, 10, p. 4578–4587

  Research output: Contribution to journal › Article › Scientific › peer-review
  11 Citations (Scopus)

• Nestin contributes to skeletal muscle homeostasis and regeneration

  Lindqvist, J., Torvaldson, E., Gullmets, J., Karvonen, H., Nagy, A., Taimen, P. & Eriksson, J., 2017, In: Journal of Cell Science. 130, 17, p. 2833–2842

  Research output: Contribution to journal › Article › Scientific › peer-review
  20 Citations (Scopus)
• 2016

  Inhibiting Notch Activity in Breast Cancer Stem Cells by Glucose Functionalized Nanoparticles Carrying γ-secretase Inhibitors

  Mamaeva, V., Niemi, R., Beck, M., Özliseli, E., Desai, D., Landor, S., Gronroos, T., Kronqvist, P., K N Pettersen, I., McCormack, E., Rosenholm, J., Linden, M. & Sahlgren, C., 2016, In: Molecular Therapy. 24, 5, p. 926–936

  Research output: Contribution to journal › Article › Scientific › peer-review
  94 Citations (Scopus)

• Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway

  Misiorek, J., Lähdeniemi, I., Nyström, J., Paramonov, V. M., Gullmets, J., Saarento, H., Rivero Müller, A., Husøy, T., Lähdeniemi, I. & Toivola, D., 2016, In: Carcinogenesis. 37, 8, p. 777–786

  Research output: Contribution to journal › Article › Scientific › peer-review
  28 Citations (Scopus)

• Keratin 8 knockdown leads to loss of the chloride transporter DRA in the colon

  Asghar, M. N., Priyamvada, S., Nyström, J., Natarajan Anbazhagan, A., Dudeja, P. K. & Toivola, D., 2016, In: AJP - Gastrointestinal and Liver Physiology. 310, 11, p. G1147–G1154

  Research output: Contribution to journal › Article › Scientific › peer-review
  14 Citations (Scopus)

• Prolonged Dye Release from Mesoporous Silica-Based Imaging Probes Facilitates Long-Term Optical Tracking of Cell Populations In Vivo

  Rosenholm, J., Gulin-Sarfraz, T., Mamaeva, V., Niemi, R., Özliseli, E., Desai, D., Antfolk, D., Haartman von, E., Lindberg, D., Prabhakar, N., Näreoja, T. & Sahlgren, C., 2016, In: Small. 12, 12, p. 1578–1592

  Research output: Contribution to journal › Article › Scientific › peer-review
  26 Citations (Scopus)
• 2015

  Absence of keratin 8 or 18 promotes antimitochondrial autoantibody formation in aging male mice

  Toivola, D., HABTEZION, A., Misiorek, J., [Unknown], ZHANG. L. X., Nyström, J., SHARPE, O., [Unknown], ROBINSON. W. H., KWAN, R. & [Unknown], OMARY. M. B., 2015, In: FASEB Journal. 29, 12, p. 5081–5089

  Research output: Contribution to journal › Article › Scientific › peer-review
  11 Citations (Scopus)

• Keratin 8 absence down-regulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism

  Helenius, T., Misiorek, J., Nyström, J., Fortelius, L., HABTEZION, A., LIAO, J., Asghar, M. N., ZHANG, H., AZHAR, S., [Unknown], OMARY. M. B. & Toivola, D., 2015, In: Molecular biology of the cell. 26, 12, p. 2298–2310

  Research output: Contribution to journal › Article › Scientific › peer-review
  36 Citations (Scopus)
• 2014

  JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size, and influences fine motor coordination.

  Komulainen, E., Zdrojewska, J., Freemantle, E., Mohammad, H., Kulesskaya, N., Deshpande, P., Marchisella, F., Mysore, R., Hollos, P., Michelsen, KA., Mågard, M. & Coffey, ET., Sept 2014, In: Frontiers in Cellular Neuroscience.

  Research output: Contribution to journal › Article › Scientific › peer-review
  25 Citations (Scopus)

• PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner

  Sjöqvist, M., Antfolk, D., Ferraris, S., Rraklli, V., Haga, C., Antila, C., Mutvei, A., Imanishi, S., Holmberg, J., Jin, S., Eriksson, J., Lendahl, U. & Sahlgren, C., 2014, In: Cell Research. 24, 4, p. 433–450

  Research output: Contribution to journal › Article › Scientific › peer-review
  39 Citations (Scopus)