Hierarchically designed bioactive glassy nanocoatings for the growth of faster and uniformly dense apatite

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)

Interna författare/redaktörer

Publikationens författare: Indranee Das, Samar K. Medda, Goutam De, Susanne Fagerlund, Leena Hupa, Mervi A. Puska, Pekka K. Vallittu
Publiceringsår: 2015
Tidskrift: Journal of the American Ceramic Society
Tidskriftsakronym: J. Am. Ceram. Soc.
Volym: 98
Nummer: 8
Artikelns första sida, sidnummer: 2428
Artikelns sista sida, sidnummer: 2437
eISSN: 1551-2916


Crack-free bioactive nanocoatings embedded with uniformly distributed silica-rich bioactive spherical aggregates were successfully prepd. in situ by controlling the micellization of a SiO2-CaO-P2O5 sol using the tri-block copolymer P123 followed by dip-coating onto a bio-inert glass substrate and calcined. These hierarchically designed nanocoatings embedded with such bioactive glassy nanospheres (BGNS) enabled to induce the deposition of a densely populated, uniform, and well-developed needlelike cryst. carbonated hydroxyapatite coating reminiscence of the mineral phase of natural bone within a short immersion time in simulated body fluid. The BGNS nanocoatings also supported the growth and attachment of human gingival fibroblasts. The results suggest that these newly designed composite nanocoatings are noncytotoxic, capable of supporting rapid and homogeneous calcium phosphate deposition as well as subsequent crystn., and likely to be promising candidates for inert glass reinforced bone implants.

Senast uppdaterad 2020-22-01 vid 03:50