Preparation of curcumin loaded mesoporous silica nanoparticles: determining polarizability inside the mesopores

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Digambara Patra, Didem Şen Karaman, Diti Desai, Elsy El Khoury, Jessica M. Rosenholm
Publisher: Pergamon
Publication year: 2016
Journal: Materials Research Bulletin
Volume number: 84
Start page: 267
End page: 272
ISSN: 0025-5408
eISSN: 1873-4227


Abstract

Curcumin loaded mesoporopus silica nanoparticles (MSN) with various surface modifications have been prepared. SEM images indicate particle sizes in the range 200–300 nm. Various percentages of curcumin were successfully loaded within the nanoparticles, whereby the resultant loading degree increases linearly with the initial curcumin concentration. The polarizability inside the pores of MSN can be measured by using curcumin as fluorescence probe, which is critical since this cannot usually be easily reached using more conventional characterization methods. It was found that the polarizability value inside the pore is about 0.32, suggesting a solvent environment similar to methanol/ethanol. However, increase in the accumulated curcumin amount on the MSN reduces the energy gap between ground and excited state that saturated at higher curcumin loading due to homo energy transfer between the molecules. Surface modification of MSN also influences the spectral properties of curcumin due to change in pH, especially local accumulation of protons.


Keywords

Microporous materials, Nanostructures, Optical properties, Surface properties, Transmission electron microscopy (TEM), X-ray diffraction

Last updated on 2019-20-04 at 05:01