Characterization of pharmaceutical surfaces with white light interferometry

G2 Magistersavhandling, civilingenjörsavhandling


Interna författare/redaktörer


Publikationens författare: Nyman Johan O
Förläggare: Åbo Akademi
Publiceringsår: 2017
Antal sidor: 83


Abstrakt


Pharmaceutical formulations today are not
only the traditional ones, such as ointments, liquids and tablets. The field of
pharmaceutical formulations has during the last decades rapidly grown, with new
recognized formulations such as orodispersible films, nanomedicines and three-dimensional
(3D) printed tablets. Being an old or a new formulation, all these formulations
have surfaces with different topographical characteristics that affect the
functionality of the dosage forms and the drug itself. Thus, the ability to
visualize and characterize these surfaces has become more and more of interest.





The main aim of this thesis was to
investigate the possibilities and the potential of using scanning white light
interferometry (SWLI) as a surface analytical tool to visualize and characterize
surfaces of different pharmaceutical formulations. The formulations studied in
this work ranged from traditional rotary press produced tablets to novel
printed formulations with nanoparticles.





The results obtained within this study
showed that it was possible to both visualize and characterize different pharmaceutical
surfaces and their topographies with SWLI. Based on the SWLI results, a deeper
insight into the understanding of different phenomena taking place on the
substrate surface of the printed formulations was achieved. Studies of the 3D
printed grid structures with smooth edges revealed weaknesses in the imaging
possibilities of round shapes with SWLI. Further investigations are suggested
to be done to overcome such problems. Moreover, the results from the printed
formulations showed the possibilities to study drug-substrate interactions in multilayer
printed formulations with SWLI.





This
work shows that scanning white light interferometry as a non-invasive surface
topographical technique can be applied to both visualize and characterize
different pharmaceutical surfaces.


Nyckelord

Pharmaceutical surfaces, Pharmacy, White light interferometry

Senast uppdaterad 2019-24-10 vid 03:24