QR encoded smart oral dosage forms by inkjet printing

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Edinger Magnus, Bar-Shalom Daniel, Sandler Niklas, Rantanen Jukka, Genina Natalja
Publisher: Elsevier
Publication year: 2018
Journal: International Journal of Pharmaceutics
Journal acronym: ijpharm
Volume number: 536
Issue number: 1
Start page: 138
End page: 145


Abstract

The use of inkjet printing (IJP) technology enables the flexible manufacturing of personalized medicine with the doses tailored for each patient. In this study we demonstrate, for the first time, the applicability of IJP in the production of edible dosage forms in the pattern of a quick response (QR) code. This printed pattern contains the drug itself and encoded information relevant to the patient and/or healthcare professionals. IJP of the active pharmaceutical ingredient (API)-containing ink in the pattern of QR code was performed onto a newly developed porous and flexible, but mechanically stable substrate with a good absorption capacity. The printing did not affect the mechanical properties of the substrate. The actual drug content of the printed dosage forms was in accordance with the encoded drug content. The QR encoded dosage forms had a good print definition without significant edge bleeding. They were readable by a smartphone even after storage in harsh conditions. This approach of efficient data incorporation and data storage combined with the use of smart devices can lead to safer and more patient-friendly drug products in the future.


Keywords

Haloperidol, Inkjet printing, Oral dosage forms, Personalized medicine, QR code, Smartphone

Last updated on 2019-15-10 at 03:18