Inkjet Printing of Drug-Loaded Mesoporous Silica Nanoparticles - A Platform for Drug Development

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Wickström H, Hilgert E, Nyman JO, Desai D, Şen Karaman D, de Beer T, Sandler N, Rosenholm JM
Förläggare: Multidisciplinary Digital Publishing Institute
Publiceringsår: 2017
Tidskrift: Molecules
Volym: 22
Nummer: 11


Abstrakt

Mesoporous silica nanoparticles (MSNs) have shown great potential in
improving drug delivery of poorly water soluble (BCS class II, IV) and
poorly permeable (BCS class III, IV) drugs, as well as facilitating
successful delivery of unstable compounds. The nanoparticle technology
would allow improved treatment by reducing adverse reactions of
currently approved drugs and possibly reintroducing previously discarded
compounds from the drug development pipeline. This study aims to
highlight important aspects in mesoporous silica nanoparticle (MSN) ink
formulation development for digital inkjet printing technology and to
advice on choosing a method (2D/3D) for nanoparticle print deposit
characterization. The results show that both unfunctionalized and
polyethyeleneimine (PEI) surface functionalized MSNs, as well as
drug-free and drug-loaded MSN–PEI suspensions, can be successfully
inkjet-printed. Furthermore, the model BCS class IV drug remained
incorporated in the MSNs and the suspension remained physically stable
during the processing time and steps. This proof-of-concept study
suggests that inkjet printing technology would be a flexible deposition
method of pharmaceutical MSN suspensions to generate patterns according
to predefined designs. The concept could be utilized as a versatile drug
screening platform in the future due to the possibility of accurately
depositing controlled volumes of MSN suspensions on various materials.


Nyckelord

drug delivery, inkjet printing technology, mesoporous silica nanoparticles


Dokument


Senast uppdaterad 2019-12-12 vid 03:58