NIR light-activated dual-modality cancer therapy mediated by photochemical internalization of porous nanocarriers with tethered lipid bilayers

A1 Journal article (refereed)


Internal Authors/Editors


Publication Details

List of Authors: Liu J, Şen Karaman D, Zhang J, Rosenholm JM, Guo X, Cai K
Publisher: Royal Society of Chemistry
Publication year: 2017
Journal: Journal of Materials Chemistry. B
Volume number: 5
Issue number: 42
Start page: 8289
End page: 8298


Abstract

To overcome endo/lysosomal restriction as well as to increase the
clinical availability of nanomedicine, we report on a NIR
stimuli-responsive nanoplatform based on mesoporous silica nanoparticles
tethered with lipid bilayers (MSN@tLB) for chemotherapy and
photodynamic dual-modality therapy. In this nanosystem, a hydrophilic
drug molecule zoledronic acid (ZOL) was first incorporated into the MSN
core with modifications of hyperbranched polyethylenimine (PEI). To
prevent the leakage of the payload, the LB shell was covalently tethered
onto the MSN core via the PEI cushion which can greatly
enhance the stability of the LB. Meanwhile, a hydrophobic
photosensitizer IR-780 iodide was introduced into the hydrophobic
compartment to endow the system with photo-activation properties. The
as-prepared MSN-ZOL@tLB-IR780 possesses high dispersion stability
stemming from the LB, as well as negligible cytotoxicity. After cellular
internalization and endo/lysosomal capture of the nanoparticles,
photochemical internalization (PCI) mediated simultaneous cargo release
and endo/lysosomal escape were achieved by local ROS production upon 808
nm irradiation, thus leading to highly efficient chemo-photodynamic
therapy on cancer cells in vitro. Such a system presents a
sophisticated platform that integrates biocompatibility, spatiotemporal
control, NIR-responsiveness, and synergistic therapies to promote cancer
therapy.


Last updated on 2019-18-06 at 04:50

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