A missense polymorphism in the putative pheromone receptor gene VN1R1 is associated with sociosexual behavior

A1 Journal article (refereed)

Internal Authors/Editors

Publication Details

List of Authors: S Henningsson, D Hovey, K Vass, H Walum, K Sandnabba, P Santtila, P Jern, L Westberg
Publisher: Nature Publishing Group
Publication year: 2017
Journal: Translational Psychiatry
Volume number: 7


Pheromones regulate social and reproductive behavior in most mammalian
species. These effects are mediated by the vomeronasal and main
olfactory systems. Effects of putative pheromones on human
neuroendocrine activity, brain activity and attractiveness ratings
suggest that humans may communicate via similar chemosignaling. Here we
studied two samples of younger and older individuals, respectively, with
respect to one nonsynonymous polymorphism in the gene encoding the
human vomeronasal type-1 receptor 1, VN1R1, and one nonsynonymous
polymorphism in the gene encoding the olfactory receptor OR7D4.
Participants in both samples had self-reported their sociosexual
behavior using the sociosexual orientation inventory, including
questions regarding lifetime number of one-night stands, number of
partners last year and expected number of partners the coming 5 years.
In women, there was a significant association between the VN1R1
polymorphism and sociosexual behavior in both samples, driven
specifically by the question regarding one-night stands. Our results
support the hypothesis that human social interaction is modulated by
communication via chemosignaling.


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