Tailoring of Proteostasis Networks with Heat Shock Factors

A2 Granskningsartikel, litteraturgranskning, systematisk granskning


Interna författare/redaktörer


Publikationens författare: Joutsen J, Sistonen L
Förläggare: COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Publiceringsår: 2019
Tidskrift: Cold Spring Harbor Perspectives in Biology
Tidskriftsakronym: CSH PERSPECT BIOL
Volym: 11
Antal sidor: 17
ISSN: 1943-0264
eISSN: 1943-0264


Abstrakt

Heat shock factors (HSFs) are the main transcriptional regulators of the heat shock response and indispensable for maintaining cellular proteostasis. HSFs mediate their protective functions through diverse genetic programs, which are composed of genes encoding molecular chaperones and other genes crucial for cell survival. The mechanisms that are used to tailor HSF-driven proteostasis networks are not yet completely understood, but they likely comprise from distinct combinations of both genetic and proteomic determinants. In this review, we highlight the versatile HSF-mediated cellular functions that extend from cellular stress responses to various physiological and pathological processes, and we underline the key advancements that have been achieved in the field of HSF research during the last decade.

Senast uppdaterad 2020-03-06 vid 02:04