Prins cyclisation of (–)-isopulegol with benzaldehyde over ZSM-5 based micro-mesoporous catalysts for production of pharmaceuticals

A1 Originalartikel i en vetenskaplig tidskrift (referentgranskad)


Interna författare/redaktörer


Publikationens författare: Ekaterina Kholkina, Päivi Mäki-Arvela, Chloe Lozachmeuer, Roman Barakov, Nataliya Shcherban, Dmitry Yu Murzin
Publiceringsår: 2019
Tidskrift: Chinese Journal of Catalysis
Tidskriftsakronym: Chin. J. Catal.
Volym: 40
Nummer: 11
Artikelns första sida, sidnummer: 1713
Artikelns sista sida, sidnummer: 1720
Antal sidor: 8
ISSN: 0253-9837
eISSN: 1872-2067


Abstrakt

Several ZSM-5 derived micro-mesoporous catalysts were investigated in Prins cyclisation of (–)-isopulegol with benzaldehyde acting as a reactant and a solvent for production of heterocyclic oxygen containing 2H-chromene derivatives including the tetrahydropyran structure and exhibiting biological activity. The investigated catalysts were characterized by nitrogen adsorption, ammonia temperature programmed desorption, adsorption-desorption of pyridine and 2,6-di-tert-butylpyridine with Fourier transform infrared spectroscopic control. For the Prins reaction performed at 70 °C, the highest yield of the desired product, equal to 67% at complete conversion of (–)-isopulegol, was obtained over a micro-mesoporous catalyst containing an optimum amount of strong acid sites and mesopores, being 12 fold larger than the size of the desired product.


Nyckelord

Micro-Mesoporous material, Prins cyclisation, Tetrahydropyran

Senast uppdaterad 2020-27-05 vid 04:42